Term
| the ___ response is closely intertwined with the process of repair. |
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Definition
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Term
| inflammation is fundamentally a ___ response. |
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Definition
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Term
| inflammation and repair may be potentially ___, underlying common chronic diseases such as rheumatoid arthritis. the inflammation response consists of two main components; ___ response and ___ response. |
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Definition
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Term
| what is the 5 step mechanism of inflammation? |
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Definition
1. vaso dilation
2. exudation - edema
3. emigration of cels
4. chemotaxis
5. phagocytosis |
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Term
true or false
the circulating cells include neutrophils, monocytes, eosinophils, lymphocytes, basophils, and platelets |
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Definition
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Term
true or false
the connective tissue cells consist of mast cells, fibroblasts, and macrophages |
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Definition
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Term
| ___ inflammation is rapid in onset. ___ inflammation is longer duration an associated with the presence of lymphocytes and macrophages. |
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Definition
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Term
| the vascular and cellular reactions of both acute and chronic inflammation are mediated by ___ factors that are derived from ___ proteins or cells and are produced in response to or activated by inflammatory stimulus. |
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Definition
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Term
| inflammation is terminated when the offending agent is __ and the secreted mediators are broken down or dissipated. |
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Definition
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Term
| vasodilation is notably induced by __ and __ ___ on vascular smooth muscle cells. |
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Definition
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Term
| vasodilation causes increased ___ of the microvasculature. |
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Definition
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Term
| ___ is the loss of fluid resulting in concentration of red blood cells in small vessels. ___ migrate toward the vascular wall and then migrate through the vascular wall into the interstitial tissue. |
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Definition
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Term
| Leukocytes begin with margination, rolling and ___ to endothelium. there is then transmigration across the enodthelium, also known as ___. lastly, there is migration in interstitial tissues towards the chemotactic stiumlus. |
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Definition
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Term
| what are the 4 molecular families that adhesion molecules belong to? |
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Definition
selectins
immunoglobulin family; ICAM, VAMs
integrins
mucin-like glycoproteins (sa heparin sulfate) |
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Term
| the type of emigrating leukocytes varies with the ___ of the inflammatory repsonse and with the type of ___. |
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Definition
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Term
| in most inflammatory response, the first 6-24 hours are dominated by ___. in 24-48 hours, the ___ are replaced by ___. |
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Definition
neutrophils
neutrophils
monocytes |
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Term
| the ___ are the most numerous in blood and they respond more rapidly. |
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Definition
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Term
| what are some of the locally produced chemical mediators of inflammation? |
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Definition
histamine
seratonin/5HT
interleukins
prostaglandins
leukotrienes |
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Term
| what are some of the plasma derived chemical mediators of inflammation? |
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Definition
kinins
complements
coagulation system
plasminolysis system
H202, NO, O2rad |
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Term
| vasodilation chemical mediators of inflammation are... |
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Definition
|
|
Term
| BV permeability chemical mediators of inflammation are... |
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Definition
histamine
bradykinin
C5a
LB4 |
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|
Term
| leukocyte adhesion chemical mediators of inflammation are... |
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Definition
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|
Term
| chemotaxis chemical mediators of inflammation are... |
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Definition
LB4
IL8
bacterial toxins
C3
C5 |
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|
Term
| pain chemical mediators of inflammation are... |
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Definition
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|
Term
| chronic inflammation can lead to... |
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Definition
| abscess, fistula, ulcer, and sinus |
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|
Term
true or false
repair is the same as regeneration |
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Definition
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Term
| the process of ___ is a cascade of events that involves the interaction of various cellular and molecular components that act in synchrony to effect wound closure by forming new tissue. the process can be understood as progressing through multiple stages, but realistically takes place as a continuum. |
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Definition
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Term
| upon tissue injury, an activated macrophage will release... |
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Definition
toxic oxygen metabolites
proteases
neutrophil chemotaxic factors
coagulation factors
AA metabolites
nitric oxide |
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Term
| activated macrophages during fibrosis will release... |
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Definition
growth factors (PDGF, FGF, TGFB)
fibrogenic cytokines
angiogenesis factors FGF
remodeling collagnesis |
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Term
| when sutures are removed, usually at the end of the first week, wound strength is approximately ___. |
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Definition
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Term
| wound strength ____ rapidly throughout the first 4 weeks and will slow at approximately the third month. it reaches a plateau at about __-___ of the tensile strength. |
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Definition
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Term
| the recovery of the tensile strength results from the excess of ___ synthesis and remodeling. |
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Definition
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Term
| what are the periodontal disease treatment options? |
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Definition
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Term
| repairs of a periodontal defect can be mediated by formation of a long ____ epithelium and bone fill, as well as root resorption, ankylosis, and fibrous adhesion. a combination of these various healing responses often occurs. |
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Definition
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Term
| after wound healing, cells of the periodontal ligament begin to divide and migrate into the site of injury. this population of ___ cells is closely associated with blood vessels in the PDL as well as the adjacent alveolar bone marrow spaces. |
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Definition
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Term
| an alternative approach for peridontal tissue regeneration is __ __ __. |
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Definition
| periodontal tissue engineering |
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Term
| ___ is used outside of the cell to trigger an effect inside of the cell for bone specific genes. |
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Definition
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