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QUIZ 2
PHARM
39
Pharmacology
Graduate
02/28/2011

Additional Pharmacology Flashcards

 


 

Cards

Term
Why does the TSH go down in hyperthyroidism   
Definition
FEEDBACK TO THE BRAIN TEELLING IT TO SHUT DOWN B/C THERE IS TO MUCH TH
Term
Which laxative contains a synthetic sugar that is hyperosmotic
Definition
Lactalose
Term
Whic Gout med works by blocking formation of Uric acid
Definition
Allopurinol or Uloric
Term
How does colchicine work
Definition

Binds to tubulin causing depolymerization which disrupts cellular fxn decreasing migration into affected area.  Blocks cell division by binding to mitotic spindles.

Inhibits Leukocyte entry into affected joint

Term
What is Colchicine used for
Definition
Gout.  Not used in acute attacks.  Pain reliever
Term
Why is Colchicine not used in acute attacks
Definition
narrow therapeutic index; GI toxicity
Term
How does Benemid work?
Definition
Inhibit reabsorption or uric acid in the proximal renal tubules.  Used for GOUT
Term
Which cells dissolve bone in the remodeling process
Definition
Osteoclasts
Term
How does Forteo work
Definition
Stimulates osteoblasts over osteoclasts.  "Human PTH" which leads to greater bone resorption
Term
What is Forteo used for
Definition
Osteoporosis
Term
Describe the difference btw Pletal & Plavix
Definition

Pletal is aplatelet aggregator inhibitor-Inhibits PDEIII which increase cAMP causing vasodilation & inhibiting aggeregation.

Plavix irreversibly modifies the platelt ADP Rc resulting in platelets that are affected for the remainder of their lifespan

Term
What is the difference btw Cytomel & Synthroid
Definition
Cytomel is active & Synthroid is precurser
Term
How do anticholinergics work in treating COPD
Definition
Prevent increases in intracellular cGMP which are caused by interaction of ACh w/ muscarinic Rc on bronchial smooth mm
Term
Why do B-2-a work in COPD & asthma
Definition
Potent bronchodilators that relax airway smooth muscle
Term
What is a combo product w/ b-2-a & anticholinergic?
Definition

Combivent

(do not use w/ peanut allergy)

Term
What is a combo product w/ a corcticosteroid & b-2-a
Definition
ADVAIR
Term
Name the famous leukotriene Rc antagonist
Definition
Singulair
Term
How does Singulair work
Definition
LT Rc antagonist which blocks leukotrienes from causing inflammation
Term
Why is theophylline not used more commonly?
Definition
Narrow therapeutic window can cause cardiotoxicity and arrythmias
Term
What is the therapeutic index of theophylline
Definition
5-15mcg/ml
Term
What are the cough stoppers that are most commonly used
Definition
codeine & dextromethorpan (DM)
Term
What are the 2 products for COPD & asthma that punctured capsule devices
Definition
Spiriva & Fordail
Term
Why is it taht patients who take albuterol commonly experience rapid heartbeat
Definition
+chronotrope due to direct sympathetic effects and peripheral vascular dilation w/ reflex tachy
Term
What drug can be given to astmatics to suppress tremors from B-2-a?
Definition
Lorazapem.  NOT b-blockers
Term
Which b-2-a is available in a breath activated MDI
Definition
Maxair
Term
What is the MOA of Atrovent
Definition

Prevents increases in intracellular cGMP by blocking interaction of ACh & muscarinic Rc

(Anticholinergic)

Term
What is the advantage of Spiriva over Atrovent
Definition
Spiriva is Long Acting
Term
What are the warnings for LAB2A?
Definition
may increase risk of asthma-related death
Term
Name LABAs
Definition

Salmeterol & Formoterol

**add on therapy only

Term
Describe MOA of S.A.B-A
Definition
2nd msngrs are actiavted and increased (andeylyl cyclase & intracellular cAMP); Protein kinase A is activated which inhibits phosphorylation of myosin & intracellular ionic Ca which dilates bronchioles
Term
What "triggers" should you counsel an asthmatic pt againts?
Definition
ASA, NSAIDS, yellow-colored products
Term
What corticosteroid is safe on pregnant pts?
Definition

Budesonide (Cat B)

 

Term
What leukotrien Rc antagonist has an unlabeled use for chronic urticaria & atopic dermatitis
Definition
Singulair
Term
What are alpha agonists used for?
Definition
Nasal decongestants
Term
which Gout medication works by increasing uric acid excretion
Definition
probenecid
Term
What foods should be avoided when taking Allopurinol
Definition
lobster, clam, shellfish, wine, liquor, beer, liver
Term
Colace
Definition
stool softener (do not take w/ mineral oil)
Term
TRansdermal patch
Definition
anticholinergic effects and effective in motion sickness
Term
Antivert
Definition

anticholinergic effect for motion sickness, may produce urinary obstruction sxs

anti-SLUDGE

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