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Pulm-Pharm
Adrenal Steroids
10
Pharmacology
Graduate
10/08/2010

Additional Pharmacology Flashcards

 


 

Cards

Term
Mechanism of Action of Corticosteroids
Definition
Intracellularly Binds HSP90-> Nucleus->GRE
Block Neutrophil Migration
Decrease Prostaglandin Synthesis
Block Cytokine release-> Decrease Ig
Metabolic Effects
Term
Metabolic Effects of Corticosteroids
Definition

Carb: Increase Gluconeogenesis from AA Protein: Increase Proteineolysis-> AA

Lipid: Increase Liposis-> FAs-> Abdomen Electrolytes: Increase Na, Cl, decrease K-> Hypokalemia and HPTN

Term
Administration Methods of Corticosteroids
Definition
IM, IV, Oral, Intraarticular, Topical Prednisone is only oral administration
Term
Pharmacokinetics of Corticosteroids
Definition
CBG 90%, Albumin (some) 10% free transport
Liver and some Kidney Redution, Hydroxylation, Conjugation
Term
Side Effects of Corticosteroid Use
Definition
Cataracts, Peptic Ulcer, Pychosis,
Osteoporosis, Myopathy, Infection,
HPTN, Hypokalemia
Term
Contraindications to Corticosteroids Use
Definition

Peptic Acid Disease

Psych Problems

Chronic Infection (TB)

Osteoporosis

Term

How should corticosteroid use be terminated?

What are the symptoms of improper termination?

Definition

Gradual decrease in dose to prevent adrenal insufficiency symptoms

Abrupt: Adrenal insufficiency(glucose crisis)

Myalgia

Arthralgia

Fever/Malais

Term
Therapeudic uses for corticosteroids
Definition
Allegies, Arthritis, Immunosuppression, Dermatological, Adrenal Insufficiency/Congenital Hyperplasia
Term

What are the uses of Spironolactone?

Adverse Effects of Spironolactone

Definition

Use:

CHF

Primary/Secondary Hyperaldosterone

Adverse

Hirsutism

Gynecomastia

Term

What are the commons steroids used for: Degenerative Joint Disease?

Asthma?

Hypoaldosterone?

Definition

DJD

Triamcinolone

Methylprednisone

Asthma

Dexamethasone

Beclomethasone

Hypoaldosterone

Fludrocortosone

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