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Pulm-Micro
LRT Bacterial Pathogens
56
Microbiology
Graduate
10/03/2010

Additional Microbiology Flashcards

 


 

Cards

Term
Signs of Streptococcus pneumoniae Pneumonia
Definition
Rales, Dull Sounds
CXR: Lobar Consolidation
WBC: Elevated
Term
Morphology of S. pneumoniae
Definition
Gram (+) diplococci/laceletpairings
Term
S. pneumoniae lab cues
Definition
Catalase(-), Optochin Sensitive, Alpha-Hemolytic, Detergent/Bile Lysis
Term
Diagnosis of S. pneumoniae
Definition
Culture
Latex Agglutination of Capsular Antigen
Quelling Reaction
Term
Nosocomial Pneumonias
Definition
Staph aureus, Streptococcus pneumoniae, Pseudomonas aeruginosa, Legionella pneumoniae
Term
Transmission of S. pneumoniae
Definition
Endogenous or Respiratory Secretions
Term
Suseptibility to S. pneumoniae
Definition
Trauma, DM, Smoking, Alcohol, Chronic Lung Disease, Malignany, Chronic Antibiotics, Narcotics, Renal Failure
Term
Pathology of S. Pneumoniae
Definition
Inflamation, Edema and Pus Formation
Term
Complications of S. Pneumoniae
Definition
(#1)Otitis Media, (#1)Meningitis, Bacteremia, Sinusitis
Term
S.pneumoniae Virulence Factors
Definition
IgA Protease
Pneumolysin
Capsule: Higher density increases Virulence, 80 Serotypes, 23 cause 90% of pneumonias from S. pneumoniae
Term
Immunity to S. pneumoniae
Definition
Innate: C3b, Phagocytosis
Adaptive: IgG(Phagocytosis), IgM(complement)
Term
Treatment of S. pneumoniae
Definition
Ampicillin/ B-lactams-> Fluroquinolones or Vancomycin
50% PBP Alterations
Term
Prevention of S. pneumoniae
Definition
Vaccine:
1)Susceptible (elder/Immunosupressed): 23 polysacciride Immunization
2)Children 7 Polysacchirides bound to protein
Term
Strep pneumoniae Buzz Words
Definition
Lobar Consolidation, Acute Onset, Shaking Chill, Pink/Red Sputum
Term
Morphology of Klebsiella pneumoniae
Definition
Gram(-) Rods
Term
Epidemiology of K. pneumoniae
Definition
Oral, GI
Term
Virulence Factors of K. pneumoniae
Definition
Capsule, endotoxin
Term
Lab Diagnosis of K.pneumoniae
Definition

MBE, or Mackonkey agar,

Biochem tests

Term
Maconkey Agar Bacteria
Definition
Klebsiella pneumoniae, E. cloi, Enterobacter
Term
Presentation of K. pneumoniae Pneumonia
Definition
Necrotizing Pneumonia with Currant Jelly Bloody Sputum
Term
Morphology of Pseudomonas aeroginosa
Definition
Aerobic, Motile, Gram(-) Rods
Term
Virulence of P.aeruginosa
Definition
Enterotoxin A: Adp-ribosylation of EF-2
Endo,Exo,Enterotoxins
Hemolysin, Leucocidin, Preoteolytic Enzymes
Capsule, Pilli
Term
Epidemiology of P.aeruginosa
Definition
Intestine, Skin, 15% of Nosocomial Pneumonias
Term
Susceptibility to P.aeruginosa
Definition
Extensive Burns, CF with Ventilator, Predisposition
Term
Complications of P.aeruginosa
Definition
Osteomyelitis, Bacteremia
Term
Lab Characteristics of P aeruginosa
Definition
Oxidase(+), Pneumocyanin, Pneumoverdin
Term
Pseudomonas aeroginosa Treatment
Definition
Susceptibility Test, followed by combo therapy
Term
Morphology of Mycoplasm pneumoniae
Definition
Small, Pleomorphic, coccobacillus, w/o cell wall
Term
Mycoplasm pneumoniae Culture
Definition
Complex Media: Sterols, Lipoprotein, 5% CO2
Term
Pneumonias that require a source for infection
Definition
Legionella pneumonphila, Coxiella burnetii, Mycobacterium avium
Term
Epidemiology of Mycoplasm pneumoniae
Definition
15% of Pneumonias, 50%of PAPs
Term
Pathogenesis of M. pneumoniae
Definition
Cytoadhesins PI with ROS prodution
Term
Presentation of M.pneumoniae
Definition
Nonproductive Cough,Patchy Infiltrate (CXR)
1-2wk incubation-> PAP-> 1-4wk Resolution
Infectious after resolution
Term
Lab Diagnosis of M.pneumoniae
Definition
Antigen Serology
Cold Agglutination Titer
Culture: Fried Egg on Sterol,lpa,CO2
Term
Treatment of M.pneumoniae
Definition
Doxacycline or Erythromycin
Term
Morphology of Legionella pneumophila
Definition
Gram(-) Rods
Term
Lab Testing of L. pneumonphila
Definition
Oxidase(+), Catalase(+)
Culture on Buffered Charcoal Yeast Agar
Term
Epidemiology of Legionella pneumonphila
Definition
Water towers, Shower focets, Air conditioners
Nosocomial, Biofilms, Amoebae
Elderly
Term
Presentation of L. pneumonphila
Definition
Bronchitis-> Confluent Pneumonia/GI Symptoms-> Abcess-> Shock, DIC
Term
Pathogenesis of Legionella
Definition
Prevent Phagosome-Lysosome Fusion, Resist Oxidative Damage
Term
Legionella with mild Walking Pneumonia
Definition
Pontiac Fever
Term
Transmission of Legionella
Definition
source only
Term
Lab Diagnosis of Legionella
Definition
Culture BCYE
EIA Urine: Picks up 80% Community strain, 20% of Nosocomial Strains
Nucleic Acid: Future
Term
Treament of Legionella
Definition
Macrolides (Azithromycin), Fluroquinolones (Levofloxacin)
Term
Immunity to Legionella
Definition
IFN-gamma production
Term
Control of Legionella
Definition
Chlorine, Heat, Copper/silver agents
Term
Presentation of Chlamydia Psittaci
Definition
Bird Contact->PAP(w/ photophobia, and severe Headache) -> Consolidation -> 20% mortality
Term
Diseases of Psittaci
Definition
Psittacosis: Parrot
Ornithosis: Non-Parrot
Term
Diagnosis of psittaci
Definition
Serology
Term
Treatment of psittaci
Definition
Tetracycline
Term
Presentation of Chlamydia pneumoniae
Definition
Otitis, Sinitus, PAPs
Term
Epidemiology of C.pneumoniae
Definition
20% of Young Community Acquired Pneumonia
Term
Diagnosis of C.pneumoniae
Definition
IgG>512, IgM>16
Term
Epidemiology of Coxiella burnetii
Definition
Sheep, Cows, Goats
In milk, Placenta, Hydes, Feces, Urine
Term
Presentation of burnetii
Definition
PAPS-> Hepatitis/ Endocarditis
Term
Disease of Coxiella burnetii
Definition
Q Fever
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