Shared Flashcard Set

Details

Prions
Prion and Diseases
14
Microbiology
Graduate
12/08/2011

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Cards

Term
What does BSE cause in Cows? If ingested?
Definition
Cow= Mad Cow Disease
Humans= vCJD
Term
Do Prions contain nucleic acids?
Definition
Nope
Term
What do most Prion diseases cause?
Definition
Spongiform encephalopathies
Term
Buzzword: Cannibalism
Definition
Kuru
Term
In what 3 diseases do patients have PrPc mutations?
Definition
CJD, GSS, FFI
Term
Main symptom of CJD?
Definition
Ataxia
Term
What is CJD misdiagnosed as usually?
Definition
Alzheimers
Term
Buzzword: Can't Sleep
Definition
FFI (Fatal Familial Insomnia)
Term
What 2 mutations do you need for CJD and FFI? (Common and unique)
Definition
Both need a mutation from Asp-->ASN at 178.

Mutation to Val at 129= CJD
Mutation to Met at 129= FFI
Term
Buzzword: Eating/working with cows in England.
Definition
BSE (Mad Cow Disease)
Term
If you see formed Plaques in sample it could be what 2 diseases?
Definition
Kuru or vCJD
Term
If you see Spongiform Vacuoles in sample what could it be?
Definition
CJD
Term
PrPc is normally found where?
Definition
Membrane surface on neurons in brain
Term
PrPSc are normally found where?
Definition
Intracellular (once PrPSc's come together, neuron takes them up and stores them in vacuoles)
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