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Principles III, Exam II
Neuro slides 28-37
10
Nursing
Graduate
02/13/2010

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Cards

Term
Where is CSF formed and absorbed?
Definition
Formed: choroid plexus of ventricles
Absorbed: arachnoid villi
Term
What is the normal hourly and daily production of CSF?
Definition
Hourly: 21 ml
Daily: 500 ml
Term
What is the flow of CSF?
Definition
choroid plexus - lateral ventricles - foramina of Munro - third ventricle - aqueduct of Sylvius - fourth ventricle - both Foramina of Lushka and Foramen of Magendie - SAS of spinal cord - brain - arachnoid villi
Term
What does glutamate do when it attaches to the NMDA receptor?
Definition
Produces conformational change that allows Na+ to flow through postsynaptic membrane
Term
What effect does glutamate have on the Ca+ channels?
Definition
Holds them open s Ca+ can continue down its concetration gradient
Term
Why is the brain vulnerable to ischemia?
Definition
It is vulnerable as it has a high O2 consumption and demand; also it is dependent on aerobic metabolism
Term
Describe cytotoxic edema
Definition
Edema occurs within minutes to hours of injury and is reversible; due to increased intracellular Ca+ and Na+ which causes the cell to take on water and swell
Term
What type of cell death occurs initally in brain ischemia?
Definition
apoptosis - which does NOT involve inflammation
Term
Describe vasogenic edema
Definition
Occurs later in the ischemic cascade, the BBB leakds large molecules (including albumin) which creates osmotic pull and pulls water with it; occurs hours to days later and is NOT REVERSIBLE
Term
What is the brain ischemia "triad"
Definition
ischemia, decreased CPP, IICP
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