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PPI, h2 blockers
treat acid and peptic ulcer
22
Pharmacology
Graduate
08/19/2012

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Cards

Term
GI pathologies include
Definition
peptic ulcer disease, GERD, irritable bowel syndrome, inflammatory bowel disease
Term
parietel cell
Definition
acid producing cells in the stomach
Term
histamine activates
Definition
H2receptor
Term
gastrin activates
Definition
G/CCK-B Receptor
Term
acetylcholine activates
Definition
M3 receptor
Term
acetylcholine
Definition
-directly stimulate gastric acid secretion,
-increasing the release of histamine from ECL cells
-increasinf the release of gastrin from Gcells
Term
gastrin
Definition
most potent inducer of acid secretion
via CNS, local distention, & components of gastric content
Term
gastrin stimulates acid by
Definition
-indirectly inducing the release of histamine from ECL cells
-directly on parietal cells
Term
somatostatin
Definition
-made by antral D cells
-released when gastric lumen becomes more acidic pH<3
-inhibit gastric acid secretions by supressing gastrin release in negative feedback loop
Term
meds to treat acid hyper-secretion
Definition
antacids
H2 receptor blockers
proton pump inhibitors
Term
examples of antacids
Definition
Sodium Bicarbonate
calcium carbonate
aluminum hydroxide
magnesium hydroxide
Term
antacds relieve symptoms
Definition
temporarily
about 2 hours
Term
excessive doses of sodium bicarbonate and calcium carbonate
Definition
may lead to metabolic alkalosis, hypercalcemia, renal insufficiency
Term
magnesium hydroxide adverse effect
Definition
diarrhea
Term
aluminum hydroxide adverse effect
Definition
constipation
Term
anatacid drug interaction
Definition
-Al and Mg known to chelate other drugs in the GI tract-form insoluble complexes
-due to gastric and urinal pH changes may affect rates of disslution, absorption, bioavailability and renal elimination of several drugs (thyroid hormones, allopurinol, imidazole antifungals, drugs that need acid for absorption)
Term
H2 receptor blocker examples
Definition
cimetidine, ranitidine, famotidine, nizatidine
Term
cimetidine
Definition
tagamet
Term
ranitidine
Definition
zantac
Term
famotidine
Definition
pepcid
Term
H2 receptor blockers
Definition
block the release of acid by inhibiting H2 receptors of ECL cells from binding histamine
Term
pharmacdynamics of H2 receptor blcokers
Definition
-highly effective in reducing nocturnal acid secretion
-highly selective, competive inhibitors of h2 receptors at parietal cells
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