Shared Flashcard Set

Details

Phase I and II metabolic Enzymes
ACPHS glass
10
Pharmacology
Graduate
09/20/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
CYP450
Definition
Phase I
Types of reactions: Oxidative metabolism, reductive metabolism, hydroxylation
Location: Smooth ER membrane in liver or small intestine
Cofactors: Heme, Oxygen, water
Term
P450 Reductase
Definition
Phase I
Reduction
Smooth ER membrane
Cofactors: NADPH
Term
Flaving containing Monooxygenases
Definition
FMO's
Phase I
Oxidative metabolism, hydroxylation, amine oxidation, dehydrogenations
Found in liver
Cofactor: Oxygen
Term
Expoxide Hydrolase
Definition
Phase I
Hydrolytic
Located in cytosol
No cofactors
Term
Carboxylesterase
Definition
Phase I
Hydrolysis, Detoxify or metabolically activated drugs, environmental toxins and carcinogens
Located in ER, cytosol, and plasma
Term
UDP glucoronsyl Transferase
Definition
Phase II
Conjugation
ER cytosolic, UDP glucoronsyl
Term
N-acetyl transferase
Definition
Phase II
Conjugation
Cytosolic
Cofactor: Acetyl CoA
Term
Glutathion S-trans
Definition
Phase II
Conjugation
Cytosol, Smooth ER
Cofactor: Glutathione
Term
Methyltransferase
Definition
Phase II
Conjugation
Found in cytosol
Cofactor: SAM
Term
Sulfotransferase
Definition
Phase II
Conjugation
Cytosol
Cofactor: PABS
Supporting users have an ad free experience!