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Pharmacology Final Drugs
Drugs for the Pharmacology Final
47
Pharmacology
Graduate
12/07/2015

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Term
Beclomethasone
Definition
Class: Glucocorticoid
System: Inflammation (Lungs)
Receptor: Glucocorticoid Receptor
MoA: Inhibits arachidonic acid
Therapeutic: Anti-inflammatory
Use: Asthma/COPD
AE's: Cough
Term
Albuterol
Definition
Class: Short acting beta agonist
System: sympathetic
Receptor: beta 2
MoA: direct agonist
Therapeutic: bronchodilation
Use: Asthma/COPD
AE's: Decreased HR
Term
Formeterol
Definition
Class: LABA
System: sympathetic
Receptor: Beta 2
MoA: Direct agonist
Therapeutic: Bronchodilation
Use: Asthma/COPD
AE's: Decreased HR
Term
Ipatropium
Definition
Class: Short acting M3 antagonist
System: PSNS
Receptor: M3
MoA: direct antagonist
Therapuetic: bronchodilation
Use: Asthma/COPD
AE's: Anticholinergic effects
Term
Tiotropium
Definition
Class: Long-acting M3 antagonist
System: PSNS
Receptor: M3
MoA: Direct antagonist
Therapeutic: bronchodilation
Use: asthma/COPD
AE's: Anticholinergic effects
Term
Atropine
Definition
Class: Antimuscarinic
System: PSNS
Receptor: Muscarinic
MoA: Competitive inverse agonist
Therapeutic: bronchodilation, increase HR
Use: Asthma/3rd degree heart block
AE's: Anticholinergic effects
Term
Adenosine
Definition
Class: Anti-arrhythmic (unique)
System: Cardiac
Receptor: Adenosine (GCPR)
MoA: Agonist
Therapeutic: SVT
Use: Arrhythmia
AE's: Flushing
Term
Amiodarone
Definition
Class: Class I,II,III,&IV anti-arrhythmic
System: Cardiac
Receptor: Lipid membrane
MoA: Alters lipid membrane/ion channels
Therapuetic: Arrhythmias, Fibriliations
Use: Arrhythmia
AE's: SVT, VT, V. Fib, Pulmonary tox
Term
Amlodipine
Definition
Class: CCB
System: Cardiac
Receptor: L-type calcium channel
MoA: Antagonist
Therapeutic: decrease contractility
Use: HTN/Angina
AE's: LE Edema
Term
Verapamil
Definition
Class: Class IV anti-arrhythmic
System: cardiac
Receptor: Calcium channel
MoA: antagonist
Therapeutic: SVT/A.fib
Use: Arrhythmia
AE's: Hypotension
Term
Ibutilide
Definition
Class: Class III Anti-arrhythmic
System: Cardiac
Receptor: K+ channel
MoA: antagonist
Therapeutic: SVT/A-Fib
Use: Arrhythmia
AE's: QT prolongation = torsades, or v.fib
Term
Procainimide
Definition
Class: Class Ia anti-arrhytmic
System: Cardiac
Receptor: Na+ channel
MoA: Antagonist
Therapeutic: Fast ventricular Arrhythmia
Use: Arrhythmia
AE's: QT prolongation = TdP or v.fib
Term
Lidocaine
Definition
Class: Class Ib anti-arrhythmic
System: Cardiac
Receptor: Na+ channel
MoA: antagonist
Therapeutic: Fast ventricular arrhythmia
Use: arrhythmia
AE's: Edema, erythema (dermatologic issue)
Term
Esmolol
Definition
Class: Beta blocker
System: Sympathetic
Receptor: beta 1
MoA: antagonist
Therapeutic: SVT/A-Fib
Use: AV node arrhythmia
AE's: hypotension
Term
Digoxin
Definition
Class: Cardiac glycoside
System: cardiac
Receptor: na/k ATPase
MoA: antagonist
Therapeutic: Enhance contractility
Use: Hypertrophic cardiac myopathy
AE's: Prolonged AV - Beware Heart Block
Term
Metoprolol
Definition
Class: Beta blocker
System: sympathetic
Receptor: beta 1
MoA: antagonist
Therapeutic: SVT/A-Fib
Use: AV node arrhythmia
AE's: Hypotension
Term
HCTZ
Definition
Class: thiazide (distal-tube diuretic)
System: Renal
Receptor: Na/Ca pump
MoA: antagonist
Therapeutic: diuresis
Use: hypertension
AE's: hypokalemia
Term
Furosemide
Definition
Class: loop diuretic
System: renal
Receptor: Na/Ca/K pump
MoA: antagonist
Therapeutic: diuresis
Use: fluid overload
AE's: hyperuricemia/hypoMg
Term
Lisinopril
Definition
Class: ACE-I
System: Renal
Receptor: Angiotensin converting enzyme
MoA: antagonist
Therapeutic: vasodilator
Use: HTN
AE's: angioedema/cough
Term
Losartan
Definition
Class: ARB
System: Renal
Receptor: angiotensin receptor
MoA: antagonist (blocker)
Therapeutic: vasodilator
Use: HTN
AE's: Hyperkalemia
Term
Aliskiren
Definition
Class: renin inhibitor
System: renal
Receptor: direct renin?
MoA: antagonist
Therapeutic: vasodilator
Use: HTN
AE's: hypotension
Term
Sacubitril
Definition
Class: hormone inhibitor
System: renal?
Receptor: angiotensin receptor neprilysin
MoA: antagonist
Thereutic: stops degradation of BNP
Use: HTN / CHF
AE's: Angioedema, hypotension
Term
Milrinone
Definition
Class: cardiac pressor
System: Cardiac
Receptor: phosphodiesterase
MoA: antagonist
Therapeutic: increase contractility
Use: Acute congestive heart failure
AE's: ventricular arrhythmia
Term
Aspirin
Definition
Class: NSAID
System: Inflammatory
Receptor: COX 1 and COX 2
MoA: Antagonist
Therapeutic: reduce thromboxaneA2 synth
Use: Anti-platelet
AE's: Bleeding, GI upset
Term
Clopidogrel
Definition
Class: P2Y1 inhibitor
System: coagulation
Receptor: P2Y1
MoA: antagonist
Therapuetic: decreases platelet adhesion
Use: anti-platelet
AE's: bleeding
Term
Dipyridamole
Definition
Class: PDE inhibitor
System: coagulation
Receptor: PDE enzyme
MoA: antagonist
Therapeutic: decrease platelet adhesion
Use: anti-platelet
AE's: bleeding
Term
Abciximab
Definition
Class: monoclonal antibody
System: coagulation
Receptor: GPIIb-IIa
MoA: antagonist
Therapeutic: inhibits cross-linking
Use: anti-platelet
AE's: thrombocytopenia
Term
Eptifibitide
Definition
Class: GPIIb-IIa inhibitor
System: coagulation
Receptor: GPIIb-IIa
MoA: antagonist
Therapeutic:inhibits cross-linking
Use: Anti-platelet
AE's: Bleeding
Term
UFH
Definition
Class: High molecular weight heparin
System: coagulation
Receptor: Anti-Thrombin III
MoA: Agonist
Therapeutic: activates AT3 to stop IIa/Xa
Use: Treatment/prevention of DVT
AE's: bleeding
Term
Enoxaparin
Definition
Class: LMW heparin
System: Coagulation
Receptor: Anti-thrombin III
MoA: Agonist
Therapeutic: activates AT3 to stop Xa
Use: Treatment/prevention of DVT
AE: bleeding
Term
Fondaparinux
Definition
Class: 5-pentasaccharide
System: coagulation
Receptor: AT3
MoA: Agonist
Therapeutic: Activates AT3
Use: Treatment/Prevention of DVT
AE's: Bleeding
Term
Coumadin
Definition
Class: Anticoagulant
System: Coagulation
Receptor: VKORC1 - Vitamin K Enzyme
MoA: Antagonist
Therapeutic: Anticoagulation
USE: DVT/PE/A-fib
AE's: Bleeding
Term
Rivaroxaban
Definition
Class: Direct Xa inhibitor
System: Coagulation
Receptor: Xa
MoA: antagonist
Therapeutic: Anticoagulation
USE: DVT/PE/A-fib
AE's: Bleeding
Term
Dabigatran
Definition
Class: Direct IIa inhibitor
System: Coagulation
Receptor: IIa
MoA: antagonist
Therapeutic: Anticoagulation
USE: DVT/PE/A-fib
AE's: Bleeding
Term
rTPA
Definition
Class: tissue plasminogen activator
System: Coagulation
Receptor: Plasmin
MoA: agonist
Therapeutic: Anticoagulation
USE: DVT/PE/A-fib
AE's: Hemorrhage
Term
Epinephrine
Definition
Class: catecholamine
System: SNS
Receptor: Alpha1
MoA: direct agonist
Therapeutic: vasoconstricton
Use: anaphylaxis
AE's: HTN
Term
Epinephrine
Definition
Class: catecholamine
System: SNS
Receptor: Beta 1
MoA: direct agonist
Therapeutic: Elevate HR
Use: Bradycardia
AE's: HTN
Term
Epinephrine
Definition
Class: catecholamine
System: sympathetic
Receptor: Beta 2
MoA: direct agonist
Theapeutic: bronchodilation
Use: Asthma
AE's: HTN
Term
Diphenhydramine
Definition
Class: H1 Antihistamine (1st gen)
System: Respiratory Tract
Receptor: H1
MoA: Inverse agonist
Therapeutic: anti-histamine
Use: Allergies
AE's: Drowsiness
Term
Hydroxyzine
Definition
Class: H1 Antihistamine (1st Gen)
System: respiratory tract
Receptor: H1
MoA: Inverse agonist
Therapeutic: Anti-histamine
Use: allergies
AE's: drowsiness
Term
Cetirizine
Definition
Class: H1 Antihistamine (2nd Gen)
System: Respiratory Tract
Receptor: H1
MoA: inverse agonist
Therapeutic: histamine
Use: Allergies
AE's: BP lowering (vasodilation)
Term
Loratadine
Definition
Class: H1 Antihistamine (2nd Gen)
System: Respiratory Tract
Receptor: H1
MoA: inverse agonist
Therapeutic: histamine
Use: Allergies
AE's: BP lowering (vasodilation)
Term
Ranitidine
Definition
Class: H2RA
Sytem: GI
Receptor: H2
MoA: inverse agonist
Therapeutic: histamine blockade
use: anti-gastric HCl
Ae's: abdominal pain, brady arrhythmia
Term
Ibuprofen
Definition
Class: NSAID
System: inflammation
Receptor: Cox-1, Cox-2
MoA: competitive antagonist
Therapeutic: Inflammation
Use: Pain
AE's: GI distress
Term
Montelukast
Definition
Class: Leukotriene receptor blocker
System: inflammation
Receptor: CysLT1
MoA: competitive antagonist
Therapeutic: bronchodilation
Use: Asthma, allergies
AE's: neuropsychiatric events
Term
Zileuton
Definition
Class: lipooxygenase inhibitor
System: inflammation
Receptor: 5-lipoxygenase
MoA: Inhibits leukotriene synthesis
Therapeutic: anti-inflammatory
Use: Asthma, allergies
AE's: neuropsychaitric events
Term
Prednisone
Definition
Class: glucocorticoid
System: inflammation (systemic)
Receptor: glucocorticoid receptor
MoA: inhibit arachidonic acid
Therapeutic: anti-inflammatory
Use: Asthma/COPD maintenace
AE's: cushings
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