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pharm
na
130
Pharmacology
Professional
03/22/2011

Additional Pharmacology Flashcards

 


 

Cards

Term
tacrine
Definition
Cholinesterase inhibitor (anticholinesterase), inc. Ach, for alzheimers and MG
Term
atropine
Definition
muscarinic receptor antagonist, to dilate eye
Term
ephedrine
Definition
Non-catecholamine, adrenergic agonist, for anaphylactic shock and acute asthma attacks, [nonspec], G(q)>Ca>contraction
Term
Phenylephedrine
Definition
non-catecholamine adrenergic agonist, for vasoconstriction, shock [alpha 1 rec]
Term
Albuterol, ritodrine
Definition
For asthma, adrenergic agonist [beta 2 rec]
Term
amphetamine
Definition
non-catecholamine adrenergic agonist, for weight loss
Term

methylphenidate

 

[what pathology is it used for?]

Definition
non-catecholamine adrenergic agonist, for narcolepsy
Term
norepinephrine
Definition
catecholamine adrenergic agonist, for bronchodilation
Term
isoproterenol
Definition
catecholamine adrenergic agonist, for bronchodilation
Term
phenoxybenzamine, phentolamine
Definition
alpha blocker, acts against epi, to vasodilate, for adrenal tumors
Term
prazosin, terazosin
Definition
alpha blocker [alpha 1], vasodilates to treat hypertension, promote urine for BPH
Term
propranolol (in adrenergic drugs)
Definition
beta blocker, to treat angina and decreases HR and oxygen consump., txt hypertension too
Term
acetazolamide
Definition
diuretic, carbonic anhydrase inhibitor, blocks NaHCO3 reabs.
Term
mannitol
Definition
diuretic, osmotic agents, prevents water reabs. at proximal tubule
Term
furosemide
Definition
loop diuretic, blocks NKCC2 channels, so Na, Cl, K can't be reabs. [TAL]
Term
HCTZ
Definition
thiazide, NCC blocker, inh. of Na and Cl reabs., can reabs. Ca++
Term
spironolactone
Definition
K sparing diuretic in [CT], inh. translocation of receptor for aldosterone transcription
Term
amiloride
Definition
K sparing diruetic, prevents ENaC act. and Na reabs.
Term
demeclocycline
Definition
ADH antagonist, receptor antagonist, for euvolemic hyponatremia
Term
tolvaptan, lixivaptan, -vaptans
Definition
ADH antagonists, for SIADH
Term
lovastatin
Definition
HMG analog, a HMG CoA reductase inh. to stop de novo cholesterol syn., cell inc. LDL-R
Term
cholestryamine, colestipol
Definition
pos. charged resin to sequester bile acids., inc. LDL-R in liver
Term
niacin
Definition
dec. LDL [ ] and inc. HDL; inh. FA breakdown, so dec. TGA
Term
fibrates
Definition
inhibit PPAR alpha TF expression, inc. LPL, inc. HDL
Term
ezetimibe
Definition
inh abs. of cholesterol from SI, limited effects
Term
verapamil, diltiazem
Definition
calcium channel blockers, to relax VSM
Term
minoxidil, hydraazine, diazode
Definition
K channel openers, desensitive to calcium, to vasodilate, stabilizes resting membrane pot.
Term
(clonidine)guanabenz, alpha methyl dopa
Definition
alpha 2 agonist, a sympathoplegic agent that centrally acts on SNS inh.
Term
propranolol (in cardiotherapeutics)
Definition
beta blocker, to dec. C.O. and BP, inc. TPR.
Term
labetolol, carvedilol
Definition
vasodilating beta receptor antagonist, lower BP, dec C.O., inc. TPR
Term
captopril
Definition
ACE inhibitor, inh. AII production, causes vasodilation, inc bradykinin
Term
Losartan, valsartan
Definition
ARB, causes vasodilation
Term
digoxin, digitalis
Definition
inc. C.O. for HF; inh. Na/K ATPase, so more Ca stays in for contractility
Term
levosimendan
Definition
cardiac glycoside, inotropic agents, inh. Na/K ATPase so Ca stays in cell and inc. contractility. Inc. C.O. for HF
Term
dopamine (in cardiotherapeutics)
Definition
short term inotrope to inc. C.O. in HF. Acts on beta adrenergist as agonist like epi, NE and AII
Term
inamrinone, milrinone (amrinone)
Definition
cAMP PDE inhibitor, inc. cAMP to inc. intracellular Ca for contractility, for HF
Term
cyclosporin
Definition
binds onto calcineurin to inhibit NFAT and subsequent IL-2 transcription
Term
FK506
Definition
binds onto calcineurin and prevents NFAT from transcription of IL-2
Term
sirolimus
Definition
mTOR inhibitor ie. rapamycin, prevents transcription of proteins that proliferate immmune cells
Term
azathioprine (AZT)
Definition
Purine nt analog, affects lymphocytes because of their purine salvage pathway
Term
mycophenolate mofetil
Definition
GTP synthesis inhibitor
Term
anti-thymocyte Ab
Definition
Ab specific to lymphocyte surface cell receptor
Term
daclizumab
Definition
Ab against CD25 IL-2 rece. on activated lymphocyte
Term
muromonab
Definition
antibody against CD3 of TCR on lymphocytes
Term
infliximab
Definition
Ab against TNF alpha
Term
etanercept
Definition
protein against TNF alpha
Term
cortisol (in immunosuppressive therapy)
Definition
binds to glucosteroid and prevents transcription of IL-2, IL-1, IFN, TFNa
Term
dexmethasone (-ones)
Definition
binds onto glucosteroid but doesn't allow transcription after dimerization
Term
cromolyn, nedocromil
Definition
reduces degranulation of mast cells and eiosinophils
Term
thioperamide
Definition
histamine receptor inverse agonists
Term
thioperamide
Definition
histamine receptor inverse agonists
Term
clobenpropit
Definition
histamine receptor inverse agonist
Term
cetirizine
Definition
2nd generation antihistamine, zyrtec
Term
lortadine
Definition
2nd generation antihistamine, claritin
Term
fexofenadine
Definition
2nd generation antihistamine, allegra
Term
ranitidine
Definition
h2 receptor inverse agonist, zantac
Term
famotidine
Definition
h2 receptor inverse agonist, pepcid
Term
cimetidine
Definition
h2 receptor inverse agonist, tagamet
Term
albuterol, pirbuterol, terbutaline
Definition
short acting beta 2 agonist, relaxes SVM around bronchioles
Term
salmeterol, farmeterol
Definition
long acting beta 2 receptor agonist, lipophilic so stays in membrane longer, bronchodilation
Term
inat-ropium, tiop-ropium
Definition
anti muscarinic for bronchodilation
Term
theophylline
Definition
bronchodilating methylxanthine, relaxes SVM, inhibit PDE and inc. cAMP
Term
ciclesonide (and most -sones)
Definition
anti-inflammatory corticosteroid for asthma
Term

cromolyn and nedocromil (for asthma)

[what are the effects on airway?]

[when do asthamatics use it?]

[mechanism?]

Definition
prophylactic for asthmatics, inhibits airway nerves, delays Cl channels to prevents degranulation
Term
zileuton
Definition
5-LOX inhibitor, arachidonic acid can't convert to LTA
Term
zileuton
Definition
5-LOX inhibitor, arachidonic acid can't convert to LTA, antiinflammatory
Term
zafirlukast, montelukast
Definition
Blocks LTD and CysLT receptor interaction, anti-inflammatory
Term
omalizumab
Definition
anti IgE
Term
Al(OH)3
Definition
antacid, weak base, most efficient
Term
famotidine, ranitidine, cimetidine (in GERD and GI)
Definition
H2-receptor blockers, prevent gastric acid secretion
Term
omeprazole
Definition
PPI, binds reversible to H/K ATPase [esomeprazole=nexium)
Term
metoclopramide
Definition
increases promotility in GI, increase LES pressure, dopamine receptor antagonist
Term
lispro, aspart, glulisine
Definition
short acting insulin (rapid)
Term
NPH insulin, lente, isophane
Definition
intermediate acting insulin
Term
detemir, glargine
Definition
basal insulin, long lasting
Term
metaformin
Definition
a biguanide, lowers livers resistance to insulin so doesn't make glucose
Term
sulfonylureas
Definition
depolarizes beta cells to increase insulin secretion
Term
thiazolidinediones
Definition
bind PPAR gamma, transcription of proteins that increase insulin actions, "inc. insulin sensitivity"
Term
roseglitazones, pioglitazone
Definition
increase insulin's activities, "increase insulin sensitivity" [types of thiazolidinediones]
Term
heparin
Definition
anticoagulant, accelerates intx w/ antithrombin with thrombin
Term
LMW heparin
Definition
binds to factor Xa, inhibition of thrombin through allosteric mech.
Term
HMW heparin
Definition
uses scaffold mech to make trimolecular complex
Term
hirudin
Definition
binds directly to thrombin, derived from leech saliva
Term
argatroban
Definition
binds directly to thrombin to anticoagulate
Term
warfarin
Definition
oral anticoagulant, inhibit vitamin K dependent clotting factors
Term
alteplase (tPA)
Definition
lyses fibrin clots
Term
Aspirin
Definition
inh. pG metabolism, inhibits COX (arachdonic acid to pG), sustains antithrombotic effects
Term
abciximab
Definition
Ab agonist against GPIIb/IIIa, preventing firbinogen from binding
Term
clopidogrel
Definition
prevents binding of ADP to cell receptor, so GPIIb/IIIa can't be activated
Term
tirofiban
Definition
bind to GPIIb/IIIa receptor as competitive inhibitor
Term
carbidopa
Definition
LAAD inhibitor (prevents degradation into peripheral circulation)
Term
levodopa
Definition
exogenous precursor to dopamine for parkisons
Term
rasagiline, selegiline
Definition
MAO inhb., retards breakdown of dopamine for parkinsons
Term
entacapone, talcapone
Definition
COMT inhibitor, prevents competition of dopamine to brain for parkinsons
Term
apomorphine
Definition
dopamine agonist for parkinsons, of "off" periods
Term
rotigotine
Definition
dopaminergic agonist for parkinsons, transdermal patch
Term
bromocriptine
Definition
toxic dopaminergic agonist for parkinsons
Term
ropinirole
Definition
dopaminergic agonist, to use as monotherapy for parkinsons (don't use w/ cimetidine)
Term
amantidine
Definition
antiviral- inh. NMDA to inc. dopamine secretion
Term
trihexyphenidyl
Definition
antimuscarinic for parkinsons
Term
benztropine
Definition
antimuscarinic agent for parkinsons
Term
biperiden
Definition
antimuscarinic agent for parkinsons
Term
procyclidine
Definition
antimuscarinic agent for parkinsons
Term
tacrine (for txt of neurological disorder)
Definition
Ach-ase inh. for alzheimers
Term
memantine
Definition
NMDA receptor antagonist for alzheimers, to prevent excitotoxic activity from too much glutamate recept. activity
Term
pramipexole
Definition
dopaminergic agonist, to use as monotherapy for parkinsons (don't use w/ cimetidine)
Term
estropipate, CEE
Definition
estrogen only HRT
Term
prempro, premphase
Definition
estrogen & progestin HRT, for endometrial hyperplasia, prevent osteoporosis
Term
mestranol and ethinyl estradiol (EE)
Definition
hormonal contraception, mestranol is inactive prodrug of EE
EE used as patch
Term
etonogesterl, levonogesterel
Definition
progestin only contraceptive
Term
norethindrone, drospirenone
Definition
progestin only contraception
Term
depo provera, nuva ring, mirena
Definition
progestin only HC
Term
mifepristone
Definition
antiprogestin emergency contraceptive, abortive
Term
tamoxifen, raloxifene
Definition
SERM-for breast cancer, for bone reabsorption (estrogen receptor modulants)
Term
danazol
Definition
weak androgen, for endometriosis
Term
exemestane, formestane
Definition
aromatase inhibitor
Term
anstrozole, letozole
Definition
aromatase inhibitor
Term
fulvestrant
Definition
antiestrogen, analog of E2
Term
clomiphene
Definition

blocks estrogen secretion

 

ovulation inducing, txt for PCOS

Term
methyltestoerone, fluoxymesterone, oxandrolone
Definition
testosterone derivatives, 17 a alkylated androgens, to reduce breast engorgement and tumors
Term
abarelix, degarelix, cetrorelix, ganirelix
Definition
GnRH antagonists, for prostate cancer txt
Term
ketoconazole
Definition

steroid synthesis inhibition

inhbits 17,20 desmolase

inhibits a lot of CYP450

Term
finasteride, putasteride
Definition
txt male pattern baldness, txt BPH
Term
finasteride, putasteride
Definition

synthesis inhibitor, 5a reductase inh

txt male pattern baldness, txt BPH

Term
finasteride, putasteride
Definition

5a reductase inh., synthesis inh.

txt male pattern baldness, txt BPH

Term
ketoconazole
Definition
steroid synthesis inhibition
Term
finasteride, putasteride
Definition

txt male pattern baldness, txt BPH

T synthesis inhibitor

Term
ketoconazole
Definition
steroid synthesis inhibition
Term
finasteride, putasteride
Definition
txt male pattern baldness, txt BPH
Term
flutamide, bicalutamide, nilutamide
Definition
androgen receptor antagonists, compete w/ T and DHT for AR binding
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