Shared Flashcard Set

Details

Pharm II
All the receptors
101
Pharmacology
Graduate
09/17/2014

Additional Pharmacology Flashcards

 


 

Cards

Term
Levodopa/Carbidopa
Definition

pre-dopamine substrate

dopa mimetic

neurodegenerative diseases

Term
Amantadine
Definition

dopa mimetic - cholinergic receptor antagonist

enhances existing dopa

parkinsons

Term
Selegilline
Definition
inhibits MAO-B irreversibly
Term
rasagilline
Definition

inhibits MAO-B

parkinsons

Term
tolcapone
Definition

inhibits COMT (dopa metabolism)

parkinsons

Term
entacapone
Definition

inhibits COMT (dopa metabolism)

parkinsons

Term
bromocriptine
Definition

D1 and D2 agonist (ergot)

parkinsons

 

Term
pramipexole
Definition

D2 agonist

parkinsons

Term
ropinirole
Definition

D2 agonist

parkinsons

Term
rotigotine
Definition

D2 agonist

parkinsons

Term
apomorphine
Definition

D-agonists for off episodes (non ergot)

parkinsons

Term
benztropine
Definition

antimuscarinic

block excitatory M-receptors, restore balance w/ DOPA

alzheimers

Term
biperiden
Definition

anti-muscarinic

block excitatory M receptors, restore balance w/ DOPA

alzheimers

Term
trihexyphenidyl
Definition

anti-muscarinic

block excitatory M receptors, restore balance w/ DOPA

alzheimers

Term
glutamate
Definition

NMDA antagonist

Alzheimers

Term
memantine
Definition

NMDA antagonist

alzheimers

Term
donezepil
Definition

AchE inhibitors (specifically in CNS)

alzheimers

Term

rivastigmine

 

Definition

AchE inhibitors (specifically in CNS)

alzheimers

Term
tacrine
Definition

AchE inhibitors (specifically in CNS)

alzheimers

Term
galantamine
Definition

AchE inhibitors (specifically in CNS)

alzheimers

Term
morphine
Definition

hyperpolarize mu > delta, kappa >> sigma

strong agonist

Narcotic

Term
meperidine
Definition

kappa > others

strong agonist

narcotic

Term
methaone
Definition

less mu than morphine

strong agonist

narcotic

Term
fetanyl
Definition

opiod agonist (strong)

narcotic

Term
heroin
Definition

acetylated morphine

strong agonist

narcotic

Term
codeine
Definition

moderate opiod agonist

narcotic

Term
Darvon
Definition

moderate opiod agonist

narcotic

Term
Pentazocine
Definition

mixed agonist

Kappa agonist, mu/sigma antagonist

narcotic

Term
buprenorphine
Definition

mixed agonist

partial mu agonist

narcotic

Term
butorphanol
Definition

mixed agonist

kappa partial agonist 

narcotic

Term
naloxone
Definition

mu > kappa, sigma opiod antagonist

narcotic

Term
naltrexone
Definition

mu > kappa, sigma opiod antagonist

narcotic

Term
halothane
Definition

increase sensitivity to GABA receptors

inhalation

anesthetic

Term
enflurane
Definition

increase sensitivity to GABA receptors

inhalation

anesthetic

Term
isoflurane
Definition

increase sensitivity to GABA receptors

inhalation

anesthetic

Term
sevoflurane
Definition

increase sensitivity to GABA receptors

inhalation

anesthetic

Term
nitrous oxide
Definition

increase sensitivity to GABA receptors

inhalation

anesthetic

Term

barbiturates

(thiopental, thiamylal)

Definition

GABA hyperpotentiators

intravenous

anesthetic

Term

benzo

(ativan and versed)

Definition

GABA hyperpotentiators

intravenous

anesthetic

Term
droperidol + fetanyl (Innovar)
Definition

dopa blocker

IV

anesthetics

Term
ketamine
Definition

NMDA antagonist

IV

anesthetic

Term
Amidate and Propofol
Definition

GABA hyperpotentiators

intravenous

anesthetic

Term
Procaine
Definition

inhibit Na+ channels of peripheral nerves, slowing depolarization

Ester

anesthetic

Term
chloroprocaine
Definition

inhibit Na+ channels of peripheral nerves, slowing depolarization

Ester

anesthetic

Term
tetracaine
Definition

inhibit Na+ channels of peripheral nerves, slowing depolarization

Ester

anesthetic

Term
mepivacaine
Definition

inhibit Na+ channels of peripheral nerves, slowing depolarization

amide

anesthetic

Term
lidocaine
Definition

inhibit Na+ channels of peripheral nerves, slowing depolarization

amide

anesthetic

Term
bupivacaine
Definition

inhibit Na+ channels of peripheral nerves, slowing depolarization

amide

anesthetic

Term
Chlorpromazine
Definition

D2 receptor competitive antagonist

typical, 1st generation

neuroleptic

Term
thiordazine
Definition

D2 receptor competitive antagonist

typical, 1st generation

neuroleptic

Term
fluphenazine
Definition

D2 receptor competitive antagonist

typical, 1st generation

neuroleptic

Term
haldol
Definition

D2 receptor competitive antagonist

typical, 1st generation

neuroleptic

Term
thiothixene
Definition

D2 receptor competitive antagonist

typical, 1st generation

neuroleptic

Term
Clozapine
Definition

5HT receptor antagonist

atypical 2nd generation

neuroleptic

Term
risperdal
Definition

5HT receptor antagonist

atypical 2nd generation

neuroleptic

Term
olanzapine
Definition

5HT receptor antagonist

atypical 2nd generation

neuroleptic

Term
seroquel
Definition

5HT receptor antagonist

atypical 2nd generation

neuroleptic

Term
geodon
Definition

5HT receptor antagonist

atypical 2nd generation

neuroleptic

Term
abilify
Definition

5HT receptor antagonist

atypical 2nd generation

neuroleptic

Term
prochlorperazine
Definition

D2 blockers in CTZ of medulla

phenothiazines

neuroleptic

Term
promethazine
Definition

D2 blockers in CTZ of medulla

phenothiazines

neuroleptic

Term
droperidol
Definition

D2 blockers in CTZ of medulla

phenothiazines

neuroleptic

Term
tigan
Definition

D2 blockers in CTZ of medulla

phenothiazines

neuroleptic

Term
Caffeine
Definition

phosphodiesterase inhibitors- increase cAMP, cGMP and adenosine agonists

methylxanthines

stimulants

Term
theophylline
Definition

phosphodiesterase inhibitors- increase cAMP, cGMP and adenosine agonists

methylxanthines

stimulants

Term
nicotine
Definition

N receptor agonist

psychomotor 

stimulants

Term
psychomotor
Definition

methylxanthine 

others (nicotine, cocaine, amphet, methylphenidate)

Term
cocaine
Definition

blocks Ne, serotonin, and dopa reuptake

psychomotor

stimulants

Term
amphetamine
Definition

stimulates release of NE/dopa stores

psychomotor

stimulants

Term
methylphenidate
Definition

stimulates release of NE/dopa stores

psychomotor

stimulants

Term
lysergic Acid diethylamide (LSD)
Definition

serotonin agonist

psychmimetic

stimulant

Term
phencyclidine
Definition

NMDA-receptor antagonist

psychomimetic

stimulant

Term
phenytoin
Definition

blocks Na+ and Ca++ channels

anti-epileptic

Term
carbamazepine
Definition

Na+ channel blocker

anti-epileptic

Term
primidone
Definition

GABa potentiator

anti-epileptic

Term
valproic acid
Definition

GABA potentiator

anti-epileptic

Term
ethosuximide
Definition

blocks T-type Ca++ channels

anti-epileptic

Term
clonazepam
Definition

allosteric GABA potentiation/hyperpolarization

BZ

anti-epileptic

Term
clorazepate
Definition

allosteric GABA potentiation/hyperpolarization

BZ

anti-epileptic

Term
felbamate
Definition

NMDA, Na+, Ca++ blocker 

adjunct 

anti-epileptic

Term
gapapentin
Definition

GABA analog, other receptor?

adjunct

anti-epileptic

Term
lamictal
Definition

Glut/Asp release inhibitor

adjunct

anti-epileptic

Term
tiagabine
Definition

GABA reuptake inhibitor

adjunct

anti-epileptic

Term
topiramate
Definition

GABA pot, Na+ blocker, Ca++ blocker

adjunct

anti-epileptic

Term
zonisamide
Definition

GABA pot, Na+ blocker, Ca ++ T-type blocker

adjunct

anti-epileptic

Term
Amitriptyline
Definition

NE and serotonin reuptake inhibitors 

TCA 1st generation

antidepressants

Term
nortriptyline
Definition

NE and serotonin reuptake inhibitors 

TCA 1st generation

antidepressants

Term
doxepin
Definition

NE and serotonin reuptake inhibitors 

TCA 1st generation

antidepressants

Term
desipramine
Definition

NE and serotonin reuptake inhibitors 

TCA 1st generation

antidepressants

Term
imipramine
Definition

NE and serotonin reuptake inhibitors 

TCA 1st generation

antidepressants

Term
amoxapine
Definition

NE and Sero reuptake inhibitors

TCA 2nd generation

antidepressants

Term
maprotiline
Definition

NE and serotonin reuptake inhibitors 

TCA 2nd generation

antidepressants

Term
Luvox
Definition

selective inhibiton of serotonin reuptake

SSRI

antidepressants

Term
effexor
Definition

cleaner inhibition of NE and 5HT reuptake 

SNRI 

antidepressants

Term
cymbalta
Definition

cleaner inhibition of NE and 5HT reuptake 

SNRI 

antidepressants

Term
remeron
Definition

5HT2 and alpha 2 antagonist

atypical

antidepressant

Term
Nardil
Definition

inhibit MAO breakdown of NE, 5HT, DA

MAOI

antidepressant

Term
Marplan
Definition

inhibit MAO breakdown of NE, 5HT, DA

MAOI

antidepressant

Term
Parnate
Definition

inhibit MAO breakdown of NE, 5HT, DA

MAOI

antidepressant

Term
lithium salts
Definition

 inositol triphosphate

BPD

antidepresants

Term
Pyrexia + prozac = symbax
Definition

combination

BPD

antidepresants

Supporting users have an ad free experience!