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Details

Pharm Cumulative
All the drugs
150
Pharmacology
Professional
11/14/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
Imanitib
Definition
Tyrosine kinase inhibitor
Term
Caffeine and theophylline
Definition
Inhibit PDE, thus increasing action of Gs
Term
Tachyphylaxis
Definition
Rapid tolerance; tyramine and amphetamine
Term
Botulinum toxin action and cure
Definition
Prevents release of Ach; give gastric lavage, emesis, or cathartic
Term
Bleach antidote
Definition
Ice cream or milk
Term
Organophosphates symptoms and antidote
Definition
SLUDGE; atropine or 2-PAM
Term
Strychnine action and cure
Definition
antagonizes glycine, used for inhibiting nerve impulses; give IV diazepam or succinylcholine
Term
Methanol poisoning antidote
Definition
emesis, lavage, or fomepizole
Term
Disulfiram
Definition
Used to discourage alcohol use by inhibiting aldehyde dehydrogenase
Term
Arsenic poisoning treatment
Definition
Lavage and dimercaprol or penicillamine to chelate
Term
Lead poisoning signs
Definition
Wrist or ankle drop; basophilic RBC stippling; lead line on gums
Term
Iron poisoning treatment
Definition
Dimercaprol
Term
Mercury poisoning signs
Definition
Chronic exposure causes hallucinations, delusions, jerky movements
Term
Dimercaprol
Definition
Chelates As, Pb, Au and Hg
Term
Penicillamine
Definition
Chelates Cu
Term
Deferoxamine
Definition
Chelates Fe
Term
Nitrite poisoning signs
Definition
Chocolate-colored blood, causes methemaglobin formation; treat with methylene blue
Term
Cyanide gas poisoning
Definition
Almond scent; inhibits oxygen use by mitochondria; form methemaglobin with sodium nitrite; also give sodium thiosulfate to induce rhodanese enzyme to clear
Term
Radon poisoning
Definition
Increased risk of lung cancer
Term
Ingested mineral acid, strong base, mineral spirits, convulsing action
Definition
NO gastric lavage, NO emesis
Term
Ingested salicylates or barbituates action
Definition
Alkalinize the urine
Term
CO poisoning
Definition
Cherry-red blood
Term
Vesamicol
Definition
Inhibits reuptake of Ach into vesicles
Term
Botulinum toxin
Definition
Inhibits release of Ach
Term
Hemicholinium
Definition
Inhibits reuptake of choline into nerve terminal
Term
Reserpine
Definition
Inhibits reuptake of dopamine into vesicles
Term
Cocaine, TCA, amphetamine action
Definition
Inhibit reputake of NE into nerve terminal
Term
MAO and COMT
Definition
Break down free NE for reuptake
Term
VMA
Definition
Breakdown product of catecholamines
Term
HVA
Definition
Breakdown product of dopamine
Term
Metyrosine
Definition
Inhibits tyrosine hydroxylase to prevent formation of dopamine, NE, and Epi
Term
Guanethadine
Definition
Inhibits release of NE from nerve terminal
Term
Bethanechol
Definition
Used to activate M receptors in bowel and bladder for postoperative ileus
Term
Methacholine
Definition
Acts on M receptors in respiratory tract, challenge test for asthma
Term
Pilocarpine
Definition
Acts on M receptors to increase salivation; has sweating side-effect (Cevimeline doesn't have the sweating)
Term
Carbachol
Definition
Carbon copy of Ach
Term
Varenicline
Definition
Acts on N receptors in the brain to relieve nicotine craving
Term
Neostigmine
Definition
Inhibits cholinesterase; used to treat myasthenia gravis; doesn't penentrate BBB
Term
Edrophonium
Definition
Inhibits cholinesterase; used to diagnose myasthenia gravis
Term
Physostigmine
Definition
Inhibits cholinesterase to treat glaucoma; also treats atropine overdose
Term
Donepezil
Definition
Cholinesterase inhibitor used to treat Alzheimer's
Term
Echothiophate
Definition
Cholinesterase inhibitor used to treat glaucoma
Term
Organophosphates (sarin, DFP)
Definition
Cholinesterase inhibitors that cause flaccid paralysis and death; treat with atropine or 2-PAM
Term
Pyridostigmine
Definition
Inhibits cholinesterase to treat myasthenia gravis
Term
Atropine
Definition
Muscarinic antagonist that causes mydriasis; also used to reverse bradycardia or AV block in MI
Term
Scopolamine
Definition
Muscarinic antagonist used to treat motion sickness; acts on CNS
Term
Tropicamide
Definition
Muscarinic antagonist used to cause mydriasis; also Homatropine
Term
Ipratroprium
Definition
Muscarinic antagonist used to treat asthma; also Tiotroprium
Term
Tolterdine
Definition
Muscarinic antagonist used to treat overactive bladder
Term
Oxybutinin and glycopyrrolate
Definition
Muscarinic antagonists used to treat bladder spasm after GU surgery
Term
Benztropine
Definition
Muscarinic antagonist used to treat Parkinson's disease
Term
Dicyclomine
Definition
Muscarinic antagonist used as antispasmodic for the bowel
Term
Tubocurarine
Definition
Nondepolarizing neuromuscular blocking agent; blocks the channel to cease effect of Ach
Term
Succinylcholine
Definition
Depolarizing neuromuscular blocking agent; holds channel open to cause permanent depolarization of the channel
Term
Rocuronium, pancuronium, vecuronium, cisatracurium, etc...
Definition
Nondepolarizing neuromuscular blocking agents; reversed by cholinesterase inhibitors (neostigmine, edrophonium)
Term
Hexamethonium
Definition
Ganglion blocker that decreases prevailing tone on all organ systems
Term
Epinephrine
Definition
Sympathomimetic that acts on all a and B receptors; used for anaphylaxis and hypotension; low doses increase HR; high doses pressor effect decreases HR
Term
Ephedrine
Definition
Similar to Epi but less pronounced effects; unsafe herbal remedy
Term
Norepinephrine
Definition
Sympathomimetic except on B2 receptors, therefore won't cause vasodilation
Term
Phenylephrine
Definition
a1 agonist; used for nasal decongestion
Term
Methoxamine
Definition
a1 agonist for hypotension IV
Term
Midrodine
Definition
a1 agonist to treat postural hypotension
Term
Xylometazoline, Oxymetazoline
Definition
a agonist used to treat red eye or as nasal spray to treat congestion
Term
Clonidine, Methyldopa
Definition
a2 agonist used to decrease BP or in craving and hot flashes
Term
Isoproterenol
Definition
B1 and B2 agonist used for heart block
Term
Dobutamine
Definition
B1 agonist used in heart failure and cardiac stress tests
Term
Metaproterenol, albuterol, salmeterol, terbutaline
Definition
B2 agonists used for asthma and to relax the uterus in premature contractions
Term
Dopamine
Definition
D1 agonist that causes vasodilation and increased renal blood flow; higher doses stimulate B1 and a1 receptors
Term
Fendolpam
Definition
D1 agonist used to decrease BP by vasodilation
Term
Amphetamine
Definition
Increases release of NE at terminal; CNS stimulant
Term
Cocaine
Definition
Inhibits reuptake of NE
Term
Tyramine
Definition
Increases release of catecholamines from terminals; causes migraines, found in red wine and some cheeses
Term
Phentolamine
Definition
Competative antagonist of a1 and a2 receptors; treats pheochromocytoma; CI in peptic ulcers
Term
Phenoxybenzamine
Definition
Irreversible a antagonist; used to treat pheochromocytoma
Term
Prazosin, terazosin, doxazosin
Definition
a1 selective antagonists; treat HTN and BPH; CI with ED drugs like Sildenafil
Term
Tamsulosin
Definition
a1 antagonist used to treat BPH
Term
Yohimbine
Definition
Enemy of Clonidine; a2 selective antagonist, increases release of NE
Term
Propranolol, timolol, nadolol, pindolol
Definition
B antagonist to treat HTN, MI, angina, arrhythmias, CHF, migraine; CI for asthmatics
Term
Acebutol, Betaxolol, Esmolol, Atenolol, Metoprolol
Definition
B1 antagonists to treat HTN and migraines
Term
Esmolol
Definition
B1 antagonist with short duration of action used IV
Term
Nebivolol
Definition
B blocker that also causes vasodilation through NO
Term
Timolol
Definition
B blocker used to treat glaucoma
Term
Acetazolamide, methazolamide, brinzolamide, dorzolamide, dichlorphenamide
Definition
Carbonic anhydrase inhibitors that cause HCO3- excretion and decreased body HCO3-; used for altitude sickness, glaucoma, metabolic alkalosis
Term
Furosemide, bumetanide, torsemide
Definition
Loop diuretics that inhibit NKCC2 channel in ascending loop of Henle; Sulfa drugs
Term
Ethacrynic acid
Definition
Loop diuretic that inhibits NKCC2 channel in ascending loop of Henle
Term
Hydrochlorothiazide
Definition
Diuretic that inhibits Na resorption at DCT; Sulfa drug
Term
Metolazone
Definition
Diuretic similar to thiazides
Term
Indapamide
Definition
Diuretic similar to thiazides
Term
Spironolactone, eplerenone
Definition
K+ sparing diuretics that antagonize aldosterone receptors
Term
Triamterene, amiloride
Definition
K+ sparing diuretics that block Na+ resorption in CD
Term
Mannitol, isosorbide, glycerin, urea
Definition
Osmotic diuretics that pull water with them into CD
Term
Vasopressin, desmopressin
Definition
ADH agonists, used to control polyuria, dehydration in pts with central diabetes insipidus
Term
Convaptan
Definition
ADH antagonist used to treat CHF and SIADH
Term
Lithium
Definition
Uncouples V2 from cAMP to induce nephrogenic diabetes insipidus
Term
Digoxin
Definition
Inhibits Na/K ATPase to increase contractility of heart by increase available intracellular Na; inhibited by K, enhanced with Ca; increases SV, CO, but decreases heart rate; first signs of toxicity are GI
Term
Inamrinone, milrinone
Definition
Inhibit cAMP PDE in heart to improve heart contractility
Term
Nesiritide
Definition
Synthetic BNP that increases cGMP to cause vasodilation therefore treats acute decompensated heart failure
Term
Quinidine
Definition
Class IA antiarrhythmic that blocks open Na channels; used for affects atria and ventricles
Term
Procainamide
Definition
Class IA antiarrhythmic that blocks open Na channels
Term
Disopyramide
Definition
Class IA antiarrhythmic that blocks open Na channels
Term
Cinchonism
Definition
Quinidine toxicity includes HA, tinnitus, purpura
Term
Lidocaine
Definition
Class IB antiarrhythmic that blocks inactivated Na channels; used in ventricular arrhythmias
Term
Mexilitine
Definition
Class IB antiarrhythmic that blocks closed Na channels
Term
Tocainide
Definition
Class IB antiarrhythmic that blocks closed Na channels
Term
Phenytoin
Definition
Class IB antiarrhythmic that blocks closed Na channels
Term
Flecainide
Definition
Class IC antiarrhythmic that blocks all Na channels; used in V-tachs and SVT
Term
Propafenone
Definition
Class IC antiarrhythmic that blocks all Na channels
Term
Moricizine
Definition
Class IC antiarrhythmic that blocks all Na channels
Term
Amiodarone
Definition
Class III antiarrhythmic that blocks K channels; used for atrial and ventricular arrhythmias
Term
Sotalol
Definition
Class III antiarrhythmic that blocks K channels
Term
Bretylium
Definition
Class III antiarrhythmic that blocks K channels
Term
Ibutilide
Definition
Class III antiarrhythmic that blocks K channels
Term
Dofetilide
Definition
Class III antiarrhythmic that blocks K channels
Term
Verapamil
Definition
Class IV antiarrhythmic that blocks Ca channels; use for SVT; no vasodilatory properties
Term
Diltiazem
Definition
Class IV antiarrhythmic that blocks Ca channels; also has vasodilatory properties
Term
Adenosine
Definition
Antiarrhythmic drug that is DOC for SVT and Wolf-Parkinson-White; enhances K conductance to hyperpolarize the cell; STOPS THE HEART
Term
Mg
Definition
Used as an antiarrhythmic for torsade de pointes
Term
Hydralazine
Definition
Vasodilator that increases cGMP to cause arteriole>venule vasodilation; used to treat HTN
Term
Isosorbide dinitrate
Definition
Vasodilator that acts by NO to increase cGMP to cause vein>arteries to dilate
Term
Sodium nitroprusside
Definition
Directly releases NO to increase cGMP to cause vasodilation in malignant HTN
Term
Minoxidil
Definition
Opens K channels to cause vasodilation in arterioles > veins
Term
Diazoxide
Definition
Opens K channels to cause vasodilation; used for malignant HTN; can cause hyperglycemia
Term
Dihydropyridines "-dipines"
Definition
Ca channel blockers that cause vasodilation; no effects on heart; treat Prinzmetal angina
Term
Captopril, "-prils"
Definition
Inhibit ACE; used to treat HTN; side effects are cough, angioedema
Term
"-sartans"
Definition
Angiotensin II receptor blockers for HTN but do not increase kallikrien so NO COUGH
Term
Ranolazine
Definition
Na channel blocker used to treat angina
Term
Bosentan
Definition
Endothelin receptor antagonist that causes vasodilation, used to treat angina
Term
Nitroglycerin
Definition
Releases NO to cause vasodilation of veins > arteries for treatment of angina
Term
Niacin
Definition
Inhibits lipolysis in adipose tissue to decrease VLDL and increase HDL
Term
Gemfibrozil, Clofibrate, Fenofibrate
Definition
Fibric acid derivatives that upregulate LPL to clear VLDL from circulation
Term
Colestipol, cholestyramine, colesevelam
Definition
Bile acid binding resins that are ingested to prevent bile acids resorption
Term
"-statins"
Definition
HMG-CoA reductase inhibitors that inhibit cholesterol precursor to decrease cholesterol production; increase LDL receptor, decrease triglycerides, increase HDL, decrease CRP, increase NO, increase plaque stability, decrease platelet aggregation
Term
Ezetimibe
Definition
Cholesterol absorption blocker
Term
Heparin
Definition
Catalyst for antithrombin III causing breakdown of Xa and thrombin, decreasing clotting; measured by PTT, inactivated by protamine sulfate; toxicity is Heparin induced Thrombocytopenia
Term
Enoxaprin, daltaparin, danaparoid
Definition
LMW heparins that are used as anticoagulants if HIT with heparin
Term
Fondaparinux
Definition
Pentasaccharide that is used as an anticoagulant if HIT with heparin
Term
Lepirudin, bivalirudin
Definition
Thrombin inhibitor, anticoagulant
Term
Argatroban, dabigatran
Definition
Thrombin inhibitors, anticoagulants
Term
Rivaroxiban
Definition
Direct inhibitor of factor X, oral; anticoagulant
Term
Warfarin
Definition
Inhibits reducing of Vitamin K, synthesis of factors VII, II, IX, X; oral; measured by INR and tested with PT; reverse with Vitamin K
Term
Protamine sulfate
Definition
Give to counteract effects of heparin
Term
Vitamin K
Definition
Give to counteract the effects of warfarin
Term
tPA
Definition
Thrombolytic; activates formation of plasmin from plasminogen, which degrades fibrin and fibrinogen
Term
Streptokinase
Definition
Thrombolytic; activates formation of plasmin from plasminogen, which degrades fibrin and fibrinogen
Term
Urokinase, anistreplase
Definition
Thrombolytic; activates formation of plasmin from plasminogen, which degrades fibrin and fibrinogen
Term
Aminocaproic acid, transexamic acid
Definition
Antifibrinolytics; inhibit action of thrombolytics to keep clots around, prevents formation of plasmin from plasminogen
Term
Aspirin
Definition
Antiplatelet; inhibits formation of COX to prevent formation of TXA2, increases bleeding time
Term
Clopidogrel, ticlopidine, prasugrel
Definition
Antiplatelet; blocks ADP receptor on platelets
Term
Abiciximab, eptifibatide, tirofiban
Definition
Antiplatelet; inhibit GPIIb/IIIa from binding to fibrinogen
Term
Cilostazol
Definition
PDE3 inhibitor, increases cAMP levels; used in intermittent claudication
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