Shared Flashcard Set

Details

Pharm CH 42
Agents That Affect Bone Mineral Homeostasis
6
Pharmacology
Professional
06/01/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
Calcitriol
Definition

CH 42 Agents That Affect Bone Mineral Homeostasis

Vitamin D, Metabolites, Analogs

 

Regulate gene transcription via the vitamin D receptor.

 

↑ blood Ca+2 levels by promoting absorption of Ca+2 from the GI tract and ↑ renal reabsorption of Ca+2 and phosphate. Stimulates release of Ca+2 from bone by its action on osteoblasts, causing them to release RANKL, which in turn activates osteoclasts.

 

↓PTH; promote innate immunity; inhibit adaptive immunity

Hypercalcemia, hypercalciuria

 

The vitamin D preparation have much longer half-life than the metabolites and analogs.

Type I rickets (vitamin D

deficiency), type II rickets (mutated vitamin D receptor), intestinal osteodystrophy, osteoporosis, osteomalacia, renal failure, malabsorption, symptomatic hypocalcemia, hypoparathyroidism

 

Term
Alendronate
Definition

CH 42 Agents That Affect Bone Mineral Homeostasis

Bisphosphonates

 

Suppress activity of osteoclasts in part via inhibition of farnesyl pyrophosphate synthase (enzyme that is critical for osteoclast survival).  Inhibit bone resorption and secondarily bone formation.

 

↓ Osteoclast activity

↓ Vitamin D production

↓ Intestinal Ca2+ export

Adynamic bone, possible renal failure, rare osteonecrosis of the jaw

Osteoporosis, bone metastases, hypercalcemia, Paget’s

 

Term
Teriparatide
Definition

CH 42 Agents That Affect Bone Mineral Homeostasis

Hormones

 

Recombinant form of PTH

Stimulates normal bone formation and ↓ incidence of fractures.

 

Stimulates bone turnover

Hypercalcemia and hypercalciuria

Osteoporosis

 

Term
Calcitonin
Definition

CH 42 Agents That Affect Bone Mineral Homeostasis

Hormones

 

↑bone mass and ↓spine fractures

 

Suppresses bone resorption

 

Osteoporosis, hypercalcemia

Paget’s

 

Term
Raloxifene
Definition

CH 42 Agents That Affect Bone Mineral Homeostasis

Selective Estrogen-Receptor Modulators

 

Interacts selectively with estrogen receptors; Inhibits bone resorption without stimulating breast or uterus

↑risk of thrombophlebitis

Rx: osteoporosis (spine but not hip

fractures), prophylaxis of breast cancer in high risk women

 

Term
Cinacalcet
Definition

CH 42 Agents That Affect Bone Mineral Homeostasis

Calcium Receptor Agonists

 

Activates Ca+2 sensing receptor in the parathyroid gland →

↓PTH secretion

nausea

Secondary hyperparathyroidism in chronic kidney disease, parathyroid carcinoma

 

Supporting users have an ad free experience!