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Pharm 42 - Bone mineral homeostasis
pharmacology of agents that affect bone mineral homeostasis
27
Pharmacology
Professional
04/14/2012

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Term
What affect do Vitamin D metabolites/analogs have on immunity?
Definition
promote innate immunity, inhibit adaptive immunity
Term
How do the half lives of Vit D preparations compare to the metabolites and analogs?
Definition
much longer half lives
Term
Bisphosphonates ("-dronate")- MOA?
Definition
suppress the activity of osteoclasts in part via inhibition of farnesyl pyrophosphate synthesis
Term
Which drugs suppress the activity of osteoclasts in part via inhibition of farnesyl pyrophosphate synthesis?
Definition
bisphosphonates
Term
what are the effects of bisphosphonates?
Definition
inhibit bone resorption and secondarily bone formation
Term
Which drugs inhibit bone resorption and secondarily bone formation?
Definition
bisphosphonates
Term
Applications of bisphosphonates?
Definition
osteoporosis, bone mets, hypercalcemia
Term
bisphosphonates - tox?
Definition
adynamic bone, possible renal failure, rare osteonecrosis of the jaw
Term
MOA of teriparatide and calcitonin?
Definition
these hormones act on their receptors coupled to G protein signaling pathways
Term
Which drugs are hormones that act on their receptors coupled to G protein signaling pathways?
Definition
teriparatide and calcitonin
Term
Effects of teriparatide?
Definition
stimulates bone turnover
Term
Which drug stimulates bone turnover?
Definition
teriparatide
Term
Effects of calcitonin?
Definition
suppresses bone resorption
Term
Which drug is a hormone that suppresses bone resorption?
Definition
calcitonin
Term
Usage of teriperitide and calcitonin?
Definition
both are used in osteoporosis, calcitonin is used for hypercalcemia
Term
teriparatide - tox?
Definition
ma cause hypercalcemia and hypercalciuria
Term
Effects of raloxifene?
Definition
inhibits bone resorption without stimulating breast or uterus
Term
Does raloxifene prevent hot flashes? It is associated with increased risk of what?
Definition
no, thrombophlebitis
Term
Which drug is associated with increased risk of thrombophlebitis?
Definition
raloxifene
Term
Cinacalcet - MOA?
Definition
activates calcium sensing receptor
Term
Which drug actives the calcium sensing receptor?
Definition
cinacalcet
Term
Applications of cinacalcet?
Definition
hyperparathyroidism
Term
which drug is basically only used in hyperparathyroidism?
Definition
cinacalcet
Term
cinacalcet - tox?
Definition
nausea
Term
which drug is associated with nausea?
Definition
cinacalcet
Term
Minerals - calcium, phosphate, strontium - effects?
Definition
strontium suppresses bone resorption and increases bone formation, the others are required for bone mineralization
Term
minerals - tox?
Definition
ectopic calcification
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