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Pharm 23
Golan Second Edition
14
Pharmacology
Graduate
02/11/2011

Additional Pharmacology Flashcards

 


 

Cards

Term
Cholesterol Synthesis Inhibitors
Definition
Lovastatin, Pravastatin, Simvastatin, Fluvastatin, Atorvastatin, Rosuvastatin
Term
Statins
Definition
(familial) Hypercholesterolemia, Coronary atherosclerosis, prophylaxis. (Myopathy, rhabdomyolysis, hepatotoxicity, dermatomyositis) [Active liver disease, pregnancy/lactation] Lower LDL, combine with niacin for LDL (myopathic risk), gemfibrozil increases levels. Bile acid sequestrants are additive
Term
Atorvastatin and rosuvastatin
Definition
Most potent statins
Term
fluvastatin
Definition
least potent statin, processed by p450 but not 3A4
Term
Lovastatin, simvastatin, atorvastatin
Definition
processed by p450 3A4
Term
Pravastatin and Rosuvastatin
Definition
not metabolized by p450
Term
Bile Acid Absorption Inhibitors
Definition
Cholestyramine, Cholesevelam, Colestipol
Term
Bile Absorption Inhibitor Characteristics
Definition
Hypercholesterolemia (increase triglyceride levels, flatulence, vitamin K deficiency) [hyperlipidemia, biliary obstruction] Second-line agents
Term
Cholestyramine
Definition
causes pruritus
Term
Cholesterol Absorption Inhibitors
Definition
Ezetimibe
Term
Ezetimibe
Definition
(familial) Primary hypercholesterolemia, Sitosterolemia. (elevated liver function tests, myopathy, myalgia) [Liver disease, elevated tests with statin] compensatory increase in hepatic cholesterol synthesis, circulates enterohepatically, increased by cyclosporine and fibrates
Term
Fibrates
Definition
Gemribrozil, Fenofibrate: Hypertriglyceridemia, Type III dysbetalipoproteinemia (Elevated tests, myopathy, arrhythmias) [avoid with statins] first line hypertriglyceridemia, increase warfarin
Term
Fenofibrate
Definition
increases clearance of cyclosporine
Term
Niacin
Definition
low HDL, Familial combined hyperlipidemia. (Hepatotoxicity, GI bleed, flushing) [Active liver disease] Flushing prevented with aspirin. Hyperuricemia and insulin resistance possible.
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