Shared Flashcard Set

Details

PHAR100 Section C
C1
19
Pharmacology
Undergraduate 1
04/17/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
Three Classes antianginal drugs
Definition
Organic nitrates
Beta-adrenergic antagonists
Calcium Channel Blockers
Term
William Heberden
Definition
First to describe Angina pectoris
Term
William Murrell
Definition
Introduced sublingual nitroglycerin, lasts 20-30min
Term
Lauder Brunton
Definition
Introduced amyl nitrite by inhalation, lasts 3-5min
Term
Angina pectoris
Definition
Due to lipid deposits in coronary arteries
Pain from diminished oxygen supply
Term
Four 'E's precipitating Angina
Definition
Eating
Exercise
Excitement
Exposure
Term
Mechanism of Action of Organic Nitrates
Definition
Vasodilation of large veins
Dilate large coronary arteries
Term
Nitroglycerin
Definition
Converted in nitric oxide and into smooth muscle results in relaxation of blood vessel
Term
Enzyme nitric oxide synthase
Definition
Converts arginine into citrulline and nitric oxide
Term
Nitroglycerin sublingual
Definition
Absorbed into blood vessels quickly under tongue, effects 20-30min
Term
Nitroglycerin oiintment
Definition
Slow onset (1 hour) but long duration
Rubbed onto skin
Term
GTN Patch
Definition
Long lasting but tolerance develops
Term
Therapeutic Uses GTN
Definition
Termination individual attack, prevention individual attack and chronic prophylaxis
Term
Beta-Adrenergic Blocking Agents
Definition
Block beta receptors in heart decreasing heart rate and myocardial contractility, cardiac output and myocardial oxygen requirements decrease
Term
Propranolol
Definition
Beta-adrenergic blocking drug
Decreases frequency of anginal attacks
Term
Nifedipine (Calcium Blocker)
Definition
Prevents sequence of events leading to constriction of arterioles, vascular smooth muscle remains dialate
Term
Cardiac glycosides (digitalis)
Definition
Binds to sodium, potassiume-ATPase and inhibits extrusion of sodium from cardiac cells, increase calcium, greater force of contraction
Term
Therapeutic Uses of Digitalis
Definition
Congestive heart failure, treatment disordered electrical rhythms of heart (arrhythmia)
Term
Adverse effects of digitalis
Definition
Nausea and vomiting, arrhythmia, blurred vision, headache, fatigue, muscle weakness, confusion
Supporting users have an ad free experience!