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Peptide Antitbiotics
VM 607 Final
14
Veterinary Medicine
Professional
02/20/2012

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Cards

Term
Glycopeptides Group
Definition
vancomysin
Term
Polymyxins Group
Definition
polymyxin B
Term
Glycopeptides Pharmacokinetics
Definition
can only give IV
renal elimination
highly nephrotoxic
Term
Glycopeptides Clinical Usages
Definition
no dosage/efficacy data
banned in food animals
never use empirically
never use as firs tline
Term
Glycopeptides Activity
Definition
Bactericidal
Both time- and concentration-dependent
Term
Glycopeptides Action
Definition
Inhibits cell wall synthesis
Only Gram + aerobes and anaerobes
Term
Polymyxins Action
Definition
disruptor of cell membranes and endotoxin effect
pokes holes in membranes of bacteria
only Gram - (aerobes and anaerobes) and Pseudomonas
Term
Polymyxins Activity
Definition
bactericidal
concentration-dependent
Term
Polymyxins Pharmacokinetics
Definition
IV only
renal elimination
Term
Polymyxins Adverse Reactions
Definition
nephrotoxic and neurotoxic when use systemically
Term
Polymyxins Clinical Usage
Definition
local use so don't have to worry about systemic toxicity
systemic use at lose doses for endotoxic activity

When using low doses, it is not really killing the bacteria
It is binding the LPS but not killing
And taking chance of developing resistance
If you use it at low doses, need to have another antibiotic on board
It will kill any resistant bacteria
But this is a dangerous game to play
Term
Bacitran Action
Definition
inhibitor of cell wall synthesis
mainly against Gram +
Term
Bacitran Activity
Definition
bactericidal
time-dependent
Term
Bacitran Adverse Reaction
Definition
highly nephrotoxic when use systemically
mostly used topically
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