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Pathology Unit V
Female Reproductive Tract: Vulva
15
Pathology
Graduate
03/06/2013

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Cards

Term
lichen sclerosis definition
Definition
atrophic dystrophy the involves the vulva
Term
incidence of lichen sclerosis
Definition
occurs in all age groups, most commonly affects post menopausal women, small percentage (1-5%) can develop squamous cell carcinoma of the vulva
Term
gross appearance of lichen sclerosis
Definition
Presents clinically as leukoplakia (white patch), patient complains of itching, dryness
Term
clinical significance of lichen sclerosis
Definition
Grossly may mimic carcinoma in situ. Is not considered a premalignant condition
Term
condyloma acuminatum definition
Definition
: genital warts of vulva, more common, papillary and distinctly elevated or somewhat flat and rugose
Term
condyloma acuminatum relationship to HPV
Definition
caused by HPV, koilocytosis, cytopathic change characterized by perinuclear cytoplasmic vacuolization and wrinkled nuclear contours hallmark of HPV, associated with 6 and 11, do not progress to cancer
Term
gross appearance of Paget disease of vulva
Definition
red, scaly, crusted, plaque that mimics the appearance of the inflammatory dermatitis
Term
explain how Paget disease of vulva differs from Paget disease of breast
Definition
: tumor cells of the vulvar disease are usually confined to the skin and skin appendages, rarely with an associated adenocarcinoma of the sweat glands. Paget's Disease of the breast is always associated with an underlying adenocarcinoma of the breast
Term
Bowen disease definition
Definition
squamous cell carcinoma in situ
Term
incidence of carcinoma of the vulva
Definition
primary carcinoma is generally uncommon (3% of genital cancers in the female); usually occurs in women over age 60. Recent increase in incidence in women 40 to 60 years of age, related to HPV.
Term
clinical signs of carcinoma of the vulva
Definition
whitish patches of epithelial thickening, pigmented, exophytic or ulcerative endophytic tumors, multifocal and warty (HPV) lesions that tend to be squamous cell carcinomas, unifocal and well-differentiated keratinizing squamous cell carcinomas (non-HPV)
Term
course of disease of carcinoma of the vulva
Definition
Carcinoma in situ of the vulva (vulvar intraepithelial neoplasia - VIN), called Bowen's disease, clinically appears as leukoplakia.
Term
Squamous cell carcinoma
Definition
The most frequent type of primary carcinoma is squamous carcinoma (90%)
Term
Basal Cell Carcinoma
Definition
remainder of carcinomas
Term
Malignant Melanoma
Definition
can be HPV or non HPV associated
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