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**Pathology 24 MEN+Pineal
Robbins and Cotran
7
Pathology
Graduate
04/04/2011

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Cards

Term
MEN1
Definition
Also Wermer Syndrome. Parathyroid, pancreas, pituitary (PPP). PP pancreatic tumor and prolactinoma in pituitary most common. Mennin protein is poorly understood. Hypoglycemia, Zollinger-Ellison, nephrolithiasis, prolactinemia
Term
MEN2A
Definition
Sipple Syndrome. Pheochromocytoma, medullary thyroid carcinoma, parathyroid hyperplasia. RET Gain-of-Function mutation (product binds glial-derived neurotrophic factor (GDNF))
Term
RET malfunctions
Definition
Loss: aganglionosis, Hirschsprung
Gain: MEN2A
Term
MEN2B
Definition
Medullary thyroid carcinomas, more aggressive, pheochromocytomas. No hyperparathyroidism. Neuromas, marfanoid habitus. Single substitution in RET causing autophosphorylation
Term
Familial Medullary Thyroid Cancer
Definition
Variant of MEN2A. Mainly medullary thyroid cancer risk but at older age
Term
Pineocytes
Definition
photosensory and neuroendocrine functions
Term
Pineal gland secretes
Definition
Melatonin, circadian rhythm control
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