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Path Test 4
Path test 4
142
Pathology
Professional
11/09/2011

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Term
No Ig + no B cells =
Definition
Bruton's
X-linked aggamglobulinemia
Term
No Ig + normal B cells =
Definition
Common variable immunodeficiency
Term
No IgA + WBC normal + B cells normal =
Definition
Selective IgA defieciency
Term
IgM increased + decreased IgA, IgG, IgE
Definition
Hyper IgM
Term
Decreased WBC + Ig Normal
Definition
DiGeorge
Term
Decreased WBC + Decreased Ig
Definition
SCID
Term
eczema + increased IgE =
Definition
Job's syndrome
Term
Exzema + thrombocytopenia =
Definition
Wiskott-Aldrich syndrome
Term
C1q esterase inhibitor deficiency
Definition
Hereditary angioedema
Term
Lung biopsy/ sputum with SILVER STAIN
Definition
Pnuemocystis jiroveci pneumonia
AIDS
Term
PAS stain
Definition
Candida
Term
Budding yeast + germ tube =
Definition
Candida
Term
Encephalitis of temporal lobe
Definition
HIV associated herpes simplex
Term
Kid at birth "no respiratory sounds on left side"
Definition
Pulmonary hypoplasia
Term
Mediastinum shift which way in Absorption atalectasis***
Definition
TOWARDS atelectasis
Term
Mediastinum shifts which way in compression atelectasis
Definition
AWAY from atalectasis
Term
Centriacinar emphysema - what part of lung? assoc with?
Definition
Apex of lung
Smoking
Term
Panacinar Emphysema - what part of lung? assoc with?
Definition
Lower lobes
Alpha-1 antitrypsin deficiency
Term
Distal acinar / paraseptal Emphysema
location?
Associated with?
Definition
Subpleural
Spontaneous pneumothorax
Term
Flattended diaphragms
Definition
emphysema
Term
hyperinflation of lungs with small heart
Definition
emphysema
Term
barrel chest
Definition
emphysema
Term
Swelling that is crepitant
Definition
Interstial emphysema
Term
Whooping cough associated with?
Definition
Interstitial emphysema
Term
Mucus plug (2)
Definition
chronic bronchitis
Resorption atalectasis
Term
IL13 gene
Definition
asthma
Term
ADAM-33 gene polymorphisms
Definition
asthma
Term
Diffuse Alveolar Damage = ?
Definition
ARDS
Term
FEV1/FVC decreased = ?
Definition
COPD
Term
Dilation of respiratory bronchiole?
Dilated bronchi and bronchioles?
Definition
Emphysema
Bronchiectasis
Term
Dilation in lower lobes BL
Definition
Bronchiectasis
Term
FVC decreased but FEV1/FVC ratio is normal
Definition
Restrictive Lung disease
Term
Ground glass xray
Definition
Restrictive disease
Term
Honeycomb
Definition
Restrictive disease = end stage
(asbestosis)
Term
Cobble stone pleural surface
Definition
Idiopathic Pulmonary Fibrosis
Term
"looks like an organizing pneumonia"
Definition
COP
Term
Plugs of organizing fibrous tissue within alveoli
Definition
COP
Term
Subpleural or peribronchial patchy airspace consolidation
Definition
COP
Term
Alveolar proteinosis
Definition
Acute Silicosis
Term
Nodules in Upper lungs - occupational risk
Definition
Chronic Silicosis
Term
Calcification of lymph nodes
Definition
Chronic Silicosis
Term
Polarized birefrigent material in lung nodules
Definition
Silicosis
Term
Feruginous body
what stain are they + with
Definition
aka Asbestos body
Asbestosis
Prussian Blue Stain
Term
5 TYPES OF COPD
Definition
(1)Asthma
(2)Emphysema
(3)Chornic Bronchitis
(4) Bronchiectasis
(5) Bronchiolitis - small air way disease

FEV1/FVC is decreased
All have Airway narrowing, loos of elastic recoil
Term
Most common manifestation of asbestos?
Definition
Pleural plaques
Term
2 cancers seen in asbestosis
Definition
Mesothelioma
Bronchogenic carcinoma
Term
BL hilar lymphadenopathy, think..
Definition
Sarcoidosis
May get in TB in immunocompromised pts
Term
"Skin plaque shoes non-caseating granuloma"
Definition
Sarcoidosis
Term
FVC decreased
FEV1 normal
Definition
Restrictive Disease
Term
"Fluffy densities" on CXR
Definition
aka bilateral hilar lymphadenopathy
Sarcoidosis
Term
ACE increased
Hypercalcemia
Definition
Sarcoid
Term
"Potato Nodes"
Definition
aka bilateral hilar lymphadenopathy
Sarcoid
Term
Interstitial noncaseating granuloma
Definition
Hypersensitivity Pneumonitis
Term
Noncaseating granuloma in pleura, septa and bronchovascular tissue
Definition
Berylliosis
Term
dDX for Non caseating granuloma
Definition
Sarcoid
Hypersensitivity pneumonitis (progressed)
Berylliosis
TB, Histo, Blasto
Term
2 Smoking related Interstial Lung Diseases
Definition
(1)Respiratory bronchiolitis-associated interstitial disease
(2)Desquamative interstitial pneumonia, DIP
Term
No fibrosis + surfactant accumulation =
Definition
Pulmonary Alveolar proteinosis
Term
Wedge shaped pulmonary infarct
Definition
PE consequence
Term
BMPR2 mutation
Definition
Idiopathic Pulmonary arterial hypertension
Term
"20-40 yo woman presents wtih dyspnea on exertion, syncope with exercise"
Definition
Idiopathic Pulmonary Hypertension
Term
"Do you get atherosceloris of the pulmonary arteries?"
Definition
Only if you have PULMONARY HTN
Term
Medial hypertrophy of pulmonary arteries
Definition
Pulmonary HTN
Term
Plexiform lesion of pulmonary arteries
Definition
Pulmonary HTN - idiopathic, congenital heart diease, or HIV/drugs
Term
Concentric laminar hypertrophy/fibrosis
Definition
Pulmonary HTN
Term
Glomerulonephritis + hemorrhagic interstitial pneumonitis =
Definition
Goodpastures
Term
"Dry cleaner" with kidney issues
Definition
Goodpastures
Term
"Alcoholic with lung abscess"
Definition
Klebsiella
Term
Guy gets organ transplant then pneumonia - bug?
Definition
Legionella
Term
2 necrotizing CAPs
Definition
Legionella
Pseudomonas
Term
"Pt has stroke, and now has pneumonia"
What kind of pneumonia?
Morphology?
Definition
Bronchopneumonia
Pathcy consolidation
Term
Lung with PATCHES OF NEUTROPHILS!! ***
Definition
Bronchopneumonia
Term
Alveoli packed with RBCs and neutrophils
Definition
Red hepatization of Lobar pneumonia
Term
Fibroblastic tufts =
Definition
organization, seen in gray hepatization of lobar pneumonia
Term
"Lymphocytic interstitial pneumonitis"
Definition
Atypical pneumonia
Term
Air fluid level in CXR =
Definition
Lung abscess
Term
Foul smelling sputum =
Definition
Probably aspiration pneumonia - anaerobe
Term
dDx for caseating granulmona =
Definition
TB, cocci, histo, blasto
Term
Ghon complex
Definition
TB - asymptomatic form
Little granuloma things in lung
Term
Yeast inside macrophage =
Definition
histoplasmosis

"Histo Hides"
Term
Yeast with broad based bud
Definition
Blastomycosis

"Blasto buds"
Term
Caseating granulomas with spherules =
Definition
Cocci
Term
Pneumonia + rash + Arizona =
Definition
Cocci
Term
Diaphragmatic pleural calcified plaques
Definition
Asbestos
Term
Arm veins fail to drain on elevation
Definition
SVC syndrome
Lung cancer
Term
Tumor associated with Horner's syndrome
Location of tumor?
Definition
Pancoast's tumor
Apex of lung on SAME side as facial abnormalities
Term
UL Enopthalmos, ptosis, miosis
Definition
Horner's syndrome
Term
Muscle weakness in pelvis and thighs =
Definition
Lambert-Eaton
associated with small cell carcinoma
Term
Lung cancer in someone <40 years, think...
Definition
Bronchial carcinoid
Term
No breath sounds + heart has shifted =
Definition
tension pneumothorax
Term
EKG activity with no pulse =
Definition
Tension penumothorax
Term
Plural studding
Definition
Mesothelioma
Term
Cancer encasing lung
Definition
Mesothelioma
Term
Sarcomatoid and glandular cells stain with calretinin
Definition
Biphasic mesothelioma
Term
"Insulation"
Definition
asbestos
Term
+ ANA(s) in SLE
Definition
Generic
Anti-dsDNA
anti-Sm
Term
+ ANA(s) in Systemic Sclerosis-Diffuse
Definition
Generic
Scl-70
anticentromere
Term
Hallmark of Systemic Sclerosis - diffuse
Definition
FIBROSIS!!!
Term
+ ANA(s) in Sjogren Syndrome
Definition
Generic
SS-A (Ro)
SS0B (La)
Term
+ ANA(s) in Inflammatory Myopahties
Definition
Generic
Jo-1
Term
+ ANA(s) in Mixed conntective Tissue Disease
Definition
U1RNP
Term
Sx of sjogren's
risk of?
Definition
Dry eye
Dry mouth
Risk of lymphoma
Term
Skin inflammtion + blisters =
Definition
Type IV hypersensitivity
Term
Acute Necrotizing vasculitis.. think
Definition
Type III hypersensitivity
Term
HLA associated disease
Definition
Ankylosing spondyltis - HLA B27
Term
Chromosome 6
Definition
HLA gene cluster location
Term
Hemolysis in test tube...
Definition
Transufions reaction
Type II hypersensitvity
Term
Yellow pt + red rash + diarrhea =
Definition
Graft vs Host disease
Term
Common variable immunodeficiency risk of what CA?
Definition
Gastric CA
Lymphoma
Term
Asthma/pollen allergy + GI issues =
Definition
IgA deficiency
Term
Mutation in Hyper IgM
Definition
CD40, CD40L
Term
BTK mutation
Definition
Bruton's Disease
Term
Pneumocystis + IgM =
Definition
Hyper IgM syndrome
Term
Recurrent bacterial infections + HUGE TONSILS =
Definition
Common variable immunodeficiency
Term
"skin popping" narcotic users
Definition
AA amyloidosis - secondary/reactive
Term
AMyloid for Brain
Definition
ABeta
Term
Amyloid for Carpal Tunnel
Definition
ABeta2m
Term
Senile cardiac amyloid
Definition
ATTR
Term
Restrictive cardiomyopathy amyloid
Definition
ATTR
Term
"Portugeuse pt"...think
Definition
ATTR Amyloid
Term
Dilated atrium...think
Definition
Amyloidosis --- restrictive cardiomyopathy
ATTR or AL
Term
two hypersensitivities associated with SLE - examples of each
Definition
Type II ---- anti-RBC gives abnormal CBC
Type III --- every other thing that happens in SLE
Term
5 major findings in SLE
Definition
1) Hematologic - 100% have abnormal CBC, Type II
2) Arthritis
3) Skin rash
4) Fever
5) Fatigue
Term
Claw hand + masked faces =
Definition
Systemic Sclerosis
Term
"My hands are stiff and it hurts to swallow"
Definition
Systemic Sclerosis
Term
MYC associated CA
Definition
small cell caricnoma
Term
EFGR + CA
Definition
adenocarcinoma
Term
KRAS+ Ca
Definition
adenocarcinoma
Term
CA that airbonre seeding --> suffocation
Definition
Bonchiolar-aveolar
Term
crackles on inspiration..think...
Definition
restrictive disease - Idiopathic Pulmonary Fibrosis
Term
2 defining features of Bronchopulmonary sequestration
Definition
(1) lung segment not connected to bronchial tree
(2) Blood supply comes from aorta
Term
3 common causes of ARDS
Definition
Sepsis
Gastric aspiration
Pancreatitis

3 ones the highlighted in class
Term
Neutrophils (2)
Definition
ARDS or bronchopneumonia
Term
Diffuse Alveolar Damage
Definition
ARDS
Term
Hyaline Membrane =
probably?
Definition
= DAD
prbobably ARDS
Term
Destruction of alveolar walls without obvious fibrosis =
Definition
emphysema
Term
PiZZ genotype
Definition
alpha-1 deficieny
Emphysema at young age +/- smoking
Term
Kid with whooping cough + face/neck swelling =
Definition
Interstitial emphysema
Term
Mucus plug (2)
Definition
Absorptioon atalectasis
Chronic Bronchitis
Term
What do leukotrienes do in asthma?
Definition
vasospasm
Vascular permeability
bronchoconstriction
Term
Bronchiectasis definition
Definition
Chronic NECROTIZING infection get permanent abnormal dilation of airways

need obstruction + infection
Term
"Dilated bronchi and bronchioles in BL lower lobes"
Definition
Bronciectasis
may have IgA deficiency
Term
Granulomas at apex of lung + hilar node granulomas
Definition
Histoplasmosis
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