Shared Flashcard Set

Details

Path 1
Regeneration and repair
11
Pathology
Graduate
09/15/2011

Additional Pathology Flashcards

 


 

Cards

Term
Epidermal Growth Factor EGF
Definition

Epidermal Growth Factor


 

  • EGFR1 mutations in Head, neck, breast, lung cancers
Term

Transforming growth factor(TGF-α)


ERB b2 receptor(HER2)

Definition
  • Transforming growth factor(TGF-α)
    • ERB B2 receptor (HER2) overexpressed in breast cancer
Term
Vascular Endothelial GF(VEGF)
Definition

Vascular Endothelial GF(VEGF)


 

  • Vasculogensis and Angiogenesis
Term

TGF-β

(Transforming GF)

Definition

TGF-β


  • Growth inhibitor for most epithelial cells
  • Fibrogenic agent -> Fibrosis
    • Fibroblast migration/replication

  • Strong anti-inflammatory effect
Term

Healing by repair, Scar formation and fibrosis

 

(Damge to what prevents healin?)

(What is healing?)

Definition

Healing by repair, Scar formation and fibrosis


  • Healing not possible if Severe damage to parenchymal and Stromal framework 
  • Main healing is repair by deposition of collagen and other ECM components creating a scar

 

Term
VEGF and DLL4
Definition

 

DLL4/Notch

  • Decrease: sprouting, EC proliferation,
  • Increases: Vessel lumen size, Vascular organization


VEGF/VEGFR

  • Increase: Sprouting, EC proliferation, EC survival
  • Decrease: Vascular organization

 

Term

Clot formation

Definition

Clot Formation

 

  • Clot formation from Rapid activatio nof coagulation pathways; contains fibrin, fibronectin, complement.
  • Clot stops bleeding and serves as scaffold for migrating cells
  • Within 24 hours neutrophils use clot as scaffold and clean out debris/bacteria via proteolytic enzymes

 

 

Term

Recovery of Tensile Strength

Definition

Fibrillar collagens(Type I) form major portion of CT in repair sites.

 

 

In 3 months 70 to 80% is the max tensile strength recovered from collagen deposition and cross-linking

Term
Primary vs Secondary union(intention)
Definition

 

Primary Union

  • Thin wound, small clot No scar formation
  • Epithelial cells can grow form side to side

 

Secondary Union

  • Scar formation, wound contraction(myofibroblats contract to bring wound together)
  •  Granulation tissue
Term

Pathologic aspects of repair

 

Keloid?

Definition

Keloid

  • Excess granulation tissue, if cut just grows back
  • More prevalent in african and americans
Term
TGF-β and Fibrosis
Definition

TGF-β and fibrosis

 

  • TGF-β is always involved as an important fibrogenic agent
  • TGF-β is important for collagen deposition
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