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Details

parkinson's drugs
n/a
16
Pharmacology
Graduate
11/18/2010

Additional Pharmacology Flashcards

 


 

Cards

Term

levodopa

 

(L-dopa)

Definition

class: dopamine precurser (enters CNS)

 

mech: direct precurser, enters CNS and is converted to dopamine by DOPA decarboxylase

 

SE- Peripheral- nausea, vomiting, orthostatic hypotension, cardiac arrhythmia

 

Central- dyskinesia, mydriasis(glaucoma)

Term
carbidopa
Definition

mech: peripheral DOPA decarboxylase inhibitor

 

function: by preventing conversion into dopamine in the periphery, more L-dopa makes it into CNS

Term

sinemet

 

(parcopa)

Definition

L dopa + carbidopa

 

more central SE, less peripheral

 

parcopa- chewable

Term

bromocriptine

 

pergolide

Definition

Class: direct dopamine agonist

 

nonselective

 

pergolide TX: valvular heart disease

Term

ropinirole

 

pramipexole

Definition

class: direct dopamine agonist

 

D2 selective

Term
apomorphine
Definition

class: parenteral dopamine agonist

 

(vomit!) rescue drug

Term

selegiline

 

rasagiline

Definition

class: monoamine oxidase inhibitor

MAOI

 

selective for MAO-B(rain)

 

function: inhibit dopamine inactivation in the CNS

 

tx: do NOT give w/ meperidine (demerol)

Term

entacapone

 

tolcapone

Definition

class: catechol-O-methyltransferase inhibitor

(COMT inhibitor)

 

function: stops dopamine and L-dopa inactivation by COMT.

 

entacapone- periphery only

 

tolcapen-both but severely hepatotoxic

Term
stalevo
Definition

combo of

L-dopa

carbidopa

entacapone

Term

benztropine

 

biperiden

 

trihexyphenidyl

Definition

class: muscarinic blocker

 

effect: decrease rigidity and tremor

 

SE- dry mouth

Term
amantidine
Definition

Class: antiviral

 

thought to alter release and reuptake of dopamine

 

limited time use

Term
MPTP
Definition
attempt at demerol caused parkinsons in 20 y.o.
Term
tacrine
Definition

class: alzheimers drug

 

mech: ACHE inhibitor

 

tx: severe hepatotoxicity

Term

donepezil

 

rivastigmine

 

galantamine

Definition

class: alzheimers

 

mech- ACHE inhibitor

Term
riluzole
Definition

class: amyotrophic lateral sclerosis

(Lou Gehrig's)

 

mech: glutamate presynaptic release and postsynaptic receptor blocker

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