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P3 - Therapy 2 - Cystic Fibrosis
P3 - Therapy 2 - Cystic Fibrosis
16
Pharmacology
Professional
09/24/2012

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Cards

Term
MSSA Drugs
Definition
Amoxicillin + Clavulanic acid, Dicloxacillin, 1st/2nd cephalosporin
Term
MRSA Drugs
Definition
Trimethoprim/Sulfamethoxazole, Doxycycline, Minocycline, Clindamycin, Linezolid
Term
S. maltophilia Drugs
Definition
Trimethoprim/Sulfamethoxazole or minocycline
Term
P. aeruginosa
Definition
Ciprofloxacin or Levofloxacin
Term
Pathogens causing early infections
Definition
SA, H-Flu, P. Aeruginosa,
Term
Rare bacteria common in CF
Definition
Burkholderia cepacia and Stenotrophomonas maltophilia
Term
Sweat test
Definition
uses pilocarpine iontophoresis to diagnose CF; Cl conc. > 60 mEq/L
Term
Dornase Alfa (adult and pediatric dose)
Definition
2.5 mg nebulized 1-2 x daily
Term
Ibuprofen (adult and pediatric dose)
Definition
20-30 mg/kg/dose twice daily
Term
Azithromycin (pediatric dose)
Definition
25-39 kg give 250 mg on Mon, Wed, Fri
Term
Azithromycin (adult dose)
Definition
40 kg or more give 500 mg on Mon, Wed, Fri
Term
Ibuprofen MOA
Definition
inhibits lipoxygenase pathway, reducing neutrophil migration and function as well as release of lysosomal enzymes
Term
Dornase Alfa MOA
Definition
cleaves DNA released during neutrophil degradation that contributes to the high viscosity of CF sputum
Term
Azithromycin MOA
Definition
maybe by interference with pseudomonas alginate biofilm production, bactericidal activity during stationary Pseudomonas growth, neutrophil inhibition, interlukin-8 reduction, and reduction in sputum viscosity
Term
Pancreatic Enzyme starting dose (adult)
Definition
500 - 1000 units/kg/meal of lipase component (1/2 for snacks)
Term
Pancreatic Enzyme starting dose (infant)
Definition
1500 - 2500 units of lipase per 120 mL of formula or breast milk
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