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Opiods
Agonists and Antagonists
24
Pharmacology
Graduate
06/08/2011

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Cards

Term
Codeine
Definition
Structurally similar to morphine, but more reliable orally
Term
Codeine
Definition
Combined with promethazine in cough suppressants
Term
Codeine
Definition
Combine w/ acetaminophen for inc pain control
Term
Codeine
Definition
Less potential for addiction and abuse compared to morphine
Term
Hdrocodone or Oxycodone
Definition
Similar to morphine and codeine, effective orally, more potent than codeine
Term
Fentanyl
Definition
A potent opiod used for chronic and breakthrough pain
Term
Loperamide HCl
Definition
Full opiod agonist w/ action limited to GI tract when taken orally; potent anti-diarrheal agent
Term
Methadone
Definition
Synthetic opiod, similar to morphine, but effective orally and used to treat drug dependence
Term
Methadone
Definition
Can cause QT prolongation and Torsades
Term
Morphine
Definition
Agonist at specific mu opiate receptors
Term
Morphine
Definition
Used especially in continuous dull pain, anxiety w/ severe pain, or sickle cell crisis
Term
Morphine
Definition
Can cause resp depression even at low doses
Term
Morphine
Definition
Pupillary constriction (miosis) is diagnostic for OD
Term
Oxycodone
Definition
Abuse of time-released formula becomeing a major problem
Term
Buprenorphine
Definition
Mu partial agonist, Kappa antagonist
Term
Buprenorphine
Definition
Used to treat cocaine abuse
Term
Pentazocine
Definition
Kappa receptor partial agoinst, Mu receptor partial agonist
Term
Pentazocine
Definition
Not used in severe or chronic pain bc of dysphoria/hallucinations at high doses or chronic low doses
Term
Propoxyphene
Definition
Very weak partial agonist with structure similar to methadone
Term
Propoxyphene
Definition
Severe toxicity problems caused recommended withdrawal from the market of all dextropropoxyphene meds bc OD risk outweighed benefits
Term
Tramadol
Definition
Inhibits NE and 5HT transport; Weak mu agonist after metabolism
Term
Naloxone
Definition
Fullopiate receptor antagonist
Term
Naloxone
Definition
Counteract effects of opiods in OD or s/p surgery
Term
Dextromethorophan
Definition
Cough suppressant with low abuse potential; no analgesia
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