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Details

Ophtho/Derm/Rheum-Pharm
Muscle Relaxants
7
Pharmacology
Graduate
12/06/2010

Additional Pharmacology Flashcards

 


 

Cards

Term
What are the muscle relaxants that act on GABA receptors and what are the pharmacodynamics of each
Definition

Benzodiazepines: GABA-A:Increase Cl conductance(Ia=Efflux, Motor=Influx)

Baclofen: GABA-B: Increase K Conductance, decrease Ca Influx

Decrease Substance P-> less pain

Gabapentin: Antiepileptic

Term
What is the mechanism of action of Tizanidine and what are the side effects?
Definition

Alpha 2  and Imidazoline Agonist

More Central than Peripheral

Sides: Dry mouth, Hypotension, Sedation

Term
How is Baclofen administered and what are the side effects
Definition

Intrathecal Admin

Sides:Seizures if Oral dose withdrawn rapidly,

Teratogenic

Term
What is the mechanism of Dantrolene and what are its uses
Definition

Blocks Ryanodine Ca Conductance in Skeletal muscle

Use: Malignant Hyperthermia, Muscle Relaxant

Term
What is the mechanism or action and use of Cyclobenaprine
Definition

Decrease Serotonergics

Use: Local Trauma, Muscle Strains

Term
What are the adverse effects of Cyclobenzoprime
Definition

Torsades

Anti-Muscarinic

Term
Which relaxants are anti-spastic and spasmotic
Definition

Both: Benodiazepine, Tirazidine

Spastic: Beclofen, Dantrolene

Spasmodic:Cycolbenaprime

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