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ODR Path
Soft Tissue Tumors & Lesions
48
Pathology
Graduate
12/14/2010

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Cards

Term
What does a dermatofibroma look like microscopically?
Definition
storiform pattern
fibroblasts and collagen
hyperplasia of overlying epidermis
Term
dermatofibroma
Definition
single or multiple slow growing, painless, firm skin nodules
gross: redddish-brown
hyerplasia overlying the epidermis
Term
fibroma molle
Definition
may start as nevis > > skin tag
fibrous tissue and mature fat
Term
fibromatoses
Definition
non-metastasizing fibroblastic tumors that invade locally and recur
fibroblasts and myofibroblasts
superficial & deep
Term
What are the superficial fibromatoses?
Definition
palmar (dupytren) and plantar
stiffening of the skin
Term
What are the deep fibromatoses?
Definition
desmoid tumors = BAD
will keep growing
intra-abdominal: treat like malignancy
Term
What is a desmoid tumor?
Definition
A deep fibromatosis
has a high recurrence
treat like a malignant tumor
Term
What fibrous tissue tumor has a herring-bone pattern?
Definition
fibrosarcoma
Term
What is seen in a dermatus fibrosarcoma protuberans?
Definition
nodular, polyploid lesion
dermis & invasion of subcutaneous tissue
slow growing
storiform pattern
trunk/extremities
Term
When do you see palmar or plantar stiffening of the skin?
Definition
superficial fibromatoses
Term
Are dermatofibromas painful?
Definition
no!
Term
Where is a fibrosarcoma most common on the body?
Definition
extremities
Term
fibrosarcoma
Definition
most common on extremities
arises from deep CT
has a herring-bone pattern
malignant
Term
What are the 2 types of reactive pseudosarcomas?
Definition
nodular fascitis
myositis ossificans
Term
What should you assume about deep tumors?
Definition
malignant until proven otherwise
Term
emrbyonal rhabdo
Definition
head & neck of children
Term
What is the most common sarcoma of adults?
Definition
malignant fibrohistiocytoma (MFH)
unknown cell of origin
histiocytes & fibroblasts
storiform pattern
Term
What is the most common soft tissue tumor of adults, and when does it typically occur?
Definition
lipoma
4th-6th decades of life
Term
Describe a lipoma.
Definition
soft, solitary, freely movable, painless
well-defined (encapsulated)
grows slowly from 1-5cm
lobules of MATURE adipost tissue
Term
Where do you typically find spindle cell lipomas?
Definition
subcutaneous tissue of neck and back of men ages 45-60
Term
Where do you see bipolar spindle cells?
Definition
spindle cell lipoma
Term
Where are angiolipomas typically seen?
Definition
in the subcutaneous layer of the forearm of young adults
Term
Why can angiolipomas be painful?
Definition
they can form microthrombi
Term
Where do you see a pleiomorphic (atypoid) lipoma?
Definition
neck and shoulder
Term
In what age group do you see lipoblastomas?
Definition
a BENIGN tumor exclusively children under age 6
Term
What is lipomatosis?
Definition
painless, deposits of fat beneat skin of neck, upper trunk, arms/legs
Term
hibernoma
Definition
arises from brown fat
benign
seen in infants and adults
Term
What are the types of liposarcomas?
Definition
well-differentiated (lipoma-like and sclerosing)
round cell
myxoid
pleimorphic
Term
What is the most common type of liposarcoma?
Definition
myxoid
Term
Describe well-differentiated liposarcomas.
Definition
occur in ages 50-70
chicken-wire vessels
lipoma-like or sclerosing
Term
What is the prognosis for each type of liposarcoma?
Definition
well-diff & myxoid = excellent
round cell & pleimorphic = poor
Term
Where are smooth muscle tumors most frequently found?
Definition
GI & Uterus
Term
Where do leiomyomas arise from?
Definition
arector pili muscles
nipple erector muscles
tunica dartos & media
Term
What condition is associted w/rhabdomyosarcoma of the heart?
Definition
tuberous sclerosis
Term
tuberous sclerosis
Definition
rhabdo
Term
What is the most common soft tissue sasrcoma of childhood and adolescence?
Definition
rhabdomyosarcoma
Term
What are the age groups associated w/each type of rhabdomyosarcoma?
Definition
embryonal: < 10yo
alveolar: 10-25yo
pleiomorphic: adults
Term
Which type of rhabdomyosarcoma has a polyploid/grape-like mass when under a mucosal membrane?
Definition
embryonal
Term
Where are pleiomorphic rhabdomyosarcomas most commonly seen?
Definition
the thigh of adults
it grows rapidly, 30% 5 year survival
Term
What are the malignant vascular tumors and the characteristics of each?
Definition
angiosarcoma: head/neck of adults
lymphangiosarcomas: older people; in extremities subjected to longstanding lymphedema; assoc w/post-mastectomy lymphedema
kaposi's: assoc w/AIDS; slit-like vasc spaces w/RBCs, reddish nodules, cutaneous nodules of distal leg
Term
what diseases are assoc w/multiple fibromas?
Definition
Neurofibromatosis
Multiple Endocrine Adenoma Syndrome
Term
What age group is most commonly affected by synovial tumors?
Definition
ages 20-40
Term
synovial sarcoma
Definition
young people/deep/bad!
Term
What are the types of fibromas?
Definition
dermatofibroma, recurrent infantile digital fibroma, acquired digital fibrokeratoma, fibroma molle
Term
lobules of mature adipose tissue, encapsulated
Definition
lipoma
Term
Where do spindle cell lipomas usually occur?
Definition
neck/back of men ages 45-60
Term
Where are pleimorphic rhabdomyosarcomas seen?
Definition
thigh of adults
Term
Which tumors are commonly found in the neck?
Definition
spindle cell lipoma, pleiomorphic lipoma, embryonal rhabdo, hemangioma ,
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