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NUR 878 Hemostasis
Brad's flashcards for Gayle's hemostasis lecture
22
Nursing
Graduate
05/16/2014

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Cards

Term
Factors in cryoprecipitate
Definition
I VIII XIII
Term
vWF deficiency Symptoms
Definition
Epistaxis, superficial bleeding and mucosal bleeding
Term
Treatment for vWF deficiency
Definition
DDAVP/desmopressin or replacement by infusion of cryo or concentrated factor VIII
Term
Dosing and how long DDAVP acts
Definition
0.3 micrograms/kg IV over 15-20 minutes.
Improved platelet adhesion in 30 minutes, lasts 4-6 hours
Term
Side affect of DDAVP
Definition
Hyponatremia, mostly in kids
Term
Steps in platelet activation
Definition
Prothrombin becomes thrombin, thrombin (factor IIa) activates platelet; exposes binding sites for fibrin
Term
Role of Thromboxane A2 and ADP in platelet activation
Definition
Both are produced by active platelet and they accelerate activation of nearby platelets
Term
Thromboxane A2
Definition
Potent vasoconstrictor, promote platelet aggregation
Term
ADP
Definition
promotes platelet "stickiness", plavix is antagonist
Term
Name of binding site for fibrin on platelet
Definition
GPIIb3a
Term
Medications that inhibit GPIIb3a binding site
Definition
Reopro (irreversible); integrellin & aggrestat (reversible)
Term
Treatment for GPIIb3a binding site inhibitor drugs
Definition
Platelet transfusion
Term
Name of fibrin mesh
Definition
White clot
Term
Regional anesthesia affect on platelet aggregation
Definition
Decreases
Term
What is the most common acquired blood clotting defect?
Definition
Inhibition of cyclo-oxygenase production by aspirin or NSAIDS.
Term
Life of a platelet
Definition
8-12 days
Term
What is the rate limiting step in arachadonic acid conversion?
Definition
Cyclo-oxygenase
Term
MOA of Aspirin
Definition
Acetylation of cyclo-oxygenase
Term
How does aspirin reduces pain?
Definition
Preventing production of prostaglandins
Term
How does aspirin increase bleeding?
Definition
Blocks production of thromboxane A2
Term
For patients on aspirin how long do you delay elective surgery?
Definition
2 weeks
Term
For patients on aspirin how do you treat them in an emergent surgery?
Definition
Give Platelets
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