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Details

Neuro/Psych-Pharm
Drugs of Abuse
23
Pharmacology
Graduate
01/20/2011

Additional Pharmacology Flashcards

 


 

Cards

Term
Diagnosis of Dependence
Definition

3 of the 7 for 1yr or more

Tolerance

Withdrawl

Larger ammounts

Cut Down

Increased time used for the drug

Loss of Social/Occupational activities

Use despite Pschological/Health impairment

Term
What are the types of tolerance
Definition

Pharmokinetics

Pharmodynamics

Behavioral

Inverse Tolerance

Term
What are the variables that generate addiction
Definition

The drug is:

Euphoric

Fast onset

Increase Dopamine

The User has:

Genetic Suseptibility

Biological parent addict

Pysch disorder

Environment is:

Acceptance of Use

Economics

Term
What are the physical and behavioral effects caused by dopamine in stimulants use
Definition

Euphoria(Accumbens)

Stereotyped Behavior(Caudate-Putamen)

Vigilence/Attention(Limbic Cortex)

Sympathetic Stimulation

Term
What are the adverse behavioral effects of chronic high dose cocaine
Definition
Paranoid Psychotic Rxns
Term
What is the duration of of action of cocaine
Definition
10-30 minutes
Term
Does cocaine exhibit tolerance or sensitization
Definition
both
Term
What are the fetal effects of maternal cocaine use
Definition
motor and cognitive impariment from ischemic cerebral effects
Term
What is the mechanism of the psychodelics
Definition
partial Agonism at 5HT2a and 5HT2c
Term
Mechanism of PCP drug
Definition
Noncompetitive block of NMDA associated Ca channel
Term
What are the physiological roles of CB1 and CB2
Definition

CB1: (Brain) Analgesia, Catalepsy

CB2: (Peripheral) Anti-Inflammatory

Term
Mechanism of THC
Definition
CB1 and CB2 which are g-protein coupled receptors which inhibit cAMP release
Term
What are drugs similar to THC used medically and what are they used for
Definition

Dronabinol: antinausea and antiemetic

Levonantradol: Analgesic, Antispasmodic

Term
What are the medical uses of THC?
Definition

Anorexia

Antiemetic

Analgesic

Movement Disorder

Term
What is the mechanism of alcohol?
Definition

Inhibition of NMDA receptor

Enhances GABA-A and 5HT3 on GABAnergic neurons

Term
What does tolerance to alcohol also convey tolerane to?
Definition
Benzos and Barbiturates
Term
What is the types of tolerance generated to alcohol
Definition

Pharmmodynamic

Pharmokinetic

Behavior

Term
Treatment of alcohol withdrawl
Definition
Short Acting Benzos
Term
What effects of benzodiazepines do not exhibit tolerance
Definition
Amnesia
Term
How are benzodiazepines most commonly abused
Definition

Potentiate other drugs or

Reduce side effects of other drugs

Term
What drugs can be used to treat benzodiazepine withdrawal and what drug is used to treat benzo toxicity
Definition

Withdrawal: Anticonvulsants

Overdose: Flumazenil

Term
Mechanism of Opiods
Definition
Mu receptor
Term
What is the diagnosis for substance abuse
Definition

One or more of the following

Use causes failure to fullfill obligations

Use causes legal problems

Use in Physically Hazardous Situations

Use despite social/interpersonal problems

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