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Nervous System Histology
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113
Histology
01/07/2012

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Term
The nerve cell body encompassing the nucleus and perikaryon is known as what?
Definition
Soma
Term
Basophilic granules observed in the perikaryon of neurons are known as what?
Definition
Nissl bodies
Term
Nissl bodies are representative of what organelle in neurons?
Definition
Highly developed arrays of rough ER
Term
What makes Nissl bodies basophilic?
Definition
Ribosomal RNA
Term
A process that occurs in the perikaryon in response to neuronal damage resulting in perikaryon swelling and displacement of Nissl bodies and the the nucleus is known as what?
Definition
Chromatolysis
Term
What is an observed change due to injury induced chromatolysis?
Definition
Rearrangement of the cytoskeleton
Term
The cytoplasm surrounding the nucleus in the soma is known as what?
Definition
Perikaryon
Term
Undigested byproducts of lysosomal activity observed in the perikaryon that accumulate with age are known as what?
Definition
Lipofuscin granules
Term
Neurofibrillar tanges in perikaryons are commonly observed in brain perparations from individuals with what disease?
Definition
Alzheimer's
Term
Extension of neurons that receive neural stimuli and transmit the input to the perikaryon are known as what?
Definition
Dendrites
Term
What organelle (aside from nuclei) are found in the perikaryon but not in dendrites?
Definition
Golgi complexes
Term
What part of the neuron transmits stimuli to another cell?
Definition
Axons
Term
The short conical region of the perikaryon from which the axon arises is known as what?
Definition
Axon hillock
Term
The portion of the neuron plasmalemma surrounding the axon is known as what?
Definition
Axolemma
Term
The cytoplasm within the axon is called what?
Definition
Axoplasm
Term
True or false: Nissl bodies are absent from the axoplasm
Definition
True
Term
What organelles are found in the axoplasm?
Definition
Mitochondria, smooth ER
Term
What is the basis for the categorization of neurons?
Definition
Number of processes emenating from the perikaryon
Term
A neuron with multiple dendrites and typically one axon is categorized as what?
Definition
Multipolar
Term
A neuron with one axon and one dendrite is categorized as what?
Definition
Bipolar
Term
A neuron that has a single process arises from the perikaryon that at some point branches into an axon and a dendrite is categorized as what?
Definition
Pseudounipolar
Term
What is the most common type of neuron?
Definition
Multipolar neurons
Term
What neurons are usually associated with highly specialized sensory organs?
Definition
Bipolar neurons
Term
What neurons are typically found in spinal ganglia and many cranial ganglia?
Definition
Pseudounipolar neurons
Term
Anterograde flow transports in what direction in neurons?
Definition
Perikaryon to the axon terminal
Term
Slow anterograde flow transports what substances?
Definition
Enzymes, tubulin, neurofilament subunits
Term
Fast anterograde flow transports what subtances? 
Definition
Synaptic vesicles and enzymes involved in neurotransmitter production, mitochondria
Term
Final production of most (but not all) neurotansmitters occurs where?
Definition
Axon terminus
Term
Retrograde transport moves substances in what direction in neurons?
Definition
From the axon terminus tot he cell body
Term
What sort of pathogens can take advantage of retrograde transport?
Definition
Neurotropic toxins and viruses
Term
Horseradish peroxidase (hrp) is an enxymes used to make what?
Definition
Neuron tracings
Term
What carries Horseradish peroxidase (hrp) from the axon terminus to the perikaryon, allowing identification of the cell body?
Definition
Retrograde trnasport
Term
The positive end of axonal microtubules are directed toward which end of the neruon?
Definition
Axon terminal
Term

The negative end of axonal microtubules are directed toward which end of the neruon?

Definition
Cell body
Term
What is the microtubule associated motor protein responsible for fast anterograde axoplasmic transport?
Definition
Kinesin
Term
What microtubule associated motor protein is responsible for retrograde axoplasmic transport?
Definition
Dynein
Term
Which axonal ending delivers the impulse?
Definition
Presynaptic terminal
Term
Where is the new impulse generated in the cell adjacent to the presynaptic terminal?
Definition
Postsynaptic terminal
Term
What is the unidirectional synapse in which nervous impulses are trnasmitted via release of chemical neurotransmitters into the synaptic cleft?
Definition
Chemical synapse
Term
What type of synapse functions by connected gap junction at the pre and postsynaptic terminals?
Definition
Electrical synapse
Term
What type of synapse has an axon-dendrite synapse?
Definition
Axodendritic
Term

What type of synapse has an axon-cell body synapse?

Definition
Axosomatic
Term

What type of synapse has an axon-axon synapse?

Definition
Axoaxonic
Term
Supportive cells for neurons are known as what?
Definition
Neuroglial cells
Term
What are the largest neuroglial cells?
Definition
Astrocytes
Term
Where are protoplasmic astrocytes found?
Definition
Gray matter
Term
Where are fibrous astrocytes found?
Definition
White matter
Term
Longer processes with fewer branches are characteristic of what?
Definition
Fibrous astrocytes
Term
A prominent nucleus and numerous short branching processes emenating from a large cell body is characteristic of what?
Definition
Protoplasmic astrocytes
Term
Tumors arising from glial cells are known as what?
Definition
Gliomas
Term
What are the general functions of astrocytes?
Definition
Uptake of ions and byproducts, scar tissue formation, neuron metabolic needs, contributes to the blood brain barrier
Term
Where are oligodendrocytes present?
Definition
Both gray and white matter?
Term
Myelin sheathes surrounding axons of the CNS are formed by what?
Definition
Oligodendrocytes
Term
What is the name of the small phagocytic cells in the CNS containing a triangular nucleus?
Definition
Microglial cells
Term
The primary function of microglial cells is to do what?
Definition
Remove debris from damaged cells in the CNS
Term
Microglial cells develop from what?
Definition
Phagocytic cells of the bone marrow
Term
Cuboidal/low columnar cells lining cavities in the CNS such as the brain ventricles and central canal of the spinal cord are called what?
Definition
Ependymal cells
Term
The choroid plexus is derived from what?
Definition
Modified ependymal cells
Term
What is the primary function of the choroid plexus?
Definition
Secretion of cerebrospinal fluid
Term
Some ependymal cells can be ciliated in order to assist in what function?
Definition
Movement of cerebrospinal fluid
Term
Where are schwann cells located?
Definition
Peripheral nervous system
Term
What forms a multi-layered myelin sheath around axons in the PNS?
Definition
Schwann cells
Term
What characteristic feature surrounds Schwanna cells and extends over the axon at the nodes of Ranvier but are absent in oligodendrocytes?
Definition
Basal lamina
Term
What envelops myelin sheathes in the PNS but not the CNS?
Definition
Connective tissue
Term
Myelin sheathes are formed from what part of Schwann cells or oligodendrocytes?
Definition
Plasmalemma
Term
Myelin is composed primarily of what compound?
Definition
Lipids
Term
Spaced breaks in the myelin sheath that expose a small portion of axons in the PNS and mark the discontinuity between two adjacent Schwann cells are known as what?
Definition
Nodes of Ranvier
Term
The myelin-wrapped portions of an axon between nodes of Ranvier are called what?
Definition
Internodal segments
Term
Light, angled disruptions in the internodal segments of myelin sheaths representing the area in which some Schwann cell or oligodendrocyte cytoplasm is trapped is referred to as what?
Definition
Schmidt-Lantermann clefts
Term
Impulse conduction resulting from the insulating properties of the myelin sheath is known as what?
Definition
Saltatory conduction
Term
Action potentions are only propagated at the nodes of Ranvier, hopping from node to node, providing what advantages to AP conduction?
Definition
Less energy consumed, dramatically increased conduction velocity
Term
What chronic CNS disease manifests as discrete patches of demyelinated axons developing throughout the CNS?
Definition
Multiple Sclerosis
Term
The CNS includes what parts of the body?
Definition
Brain and spinal cord
Term
True or false: The CNS contains supporting connective tissue stroma
Definition
False
Term
What makes white matter white?
Definition
Large amount of myelinated fibers
Term
What makes gray matter gray?
Definition
Paucity of myelin
Term
A mass of interwining axons, dendrites, and glial cell extensions in gray matter occupying the space between neurons and glial cells is known as what?
Definition
Neuropil
Term
Clusters of gray matter surrounded by white matter is known as what in the CNS?
Definition
Nuclei
Term
What is the orientation of white and gray matter in the brain?
Definition
Gray in the cortex of cerebrum and cerebellum, white in the central region
Term
What is the orientation of white and gray matter in the spinal cord?
Definition
Gray matter in the deep portion where it forms a characteristic "H" or "butterfly" shape, white in the periphery
Term
What is contained within ventral horns of the spinal cord?
Definition
Large perikaryons of multipolar neurons
Term
The vestige of the embryonic neural tube lumen that resides in the center of the "H" crossbar of gray matter in the spinal cord is known as what?
Definition
Central canal
Term
What is the order of the meninges from outermost to innermost?
Definition
Dura mater, Arachnoid, Pia mater
Term
What spans the subarachnoid space and gives the arachnoid its spiderweb-like appearance?
Definition
Trabeculae
Term
The area between the dura mater and arachnoid that can be separated due to hemorrhaging is known as what?
Definition
Subdural space
Term
The cavities in the brain that form a continuous channel for flow of cerebrospinal fluid is known as what?
Definition
Ventricles
Term
What cerebrospinal fluid secreting structure composed of ependymal cells resides in each of four dialted ventricles?
Definition
Choroid plexus
Term
What ions are found in cerebrospinal fluid?
Definition
Na+, K+, Cl-
Term
Small specialized projections of the arachnoid that extend into the dura mater, providing a means for cerebrospinal fluid reabsorption into the venous blood are referred to as what?
Definition
Arachnoid villi
Term
All portions of the nervous system outside the brain and spinal cord are collectively referred to as what?
Definition
Peripheral Nervous System
Term
Efferent motor neurons carry motor impulsues to an effector organ and originate from where?
Definition
CNS
Term
Efferent neurons that initiate skeletal muscle contraction without synapsing with intermediate neurons are classified as what?
Definition
Direct efferent neurons
Term
Effector neurons that enter an autonomic ganglion that synapse with a second neuron which in turn innervates an effector are categorized as what?
Definition
Indirect efferent neurons
Term
What are the three distinct layers of connective tissue surrounding a peripheral nerve?
Definition
Epineurium, Perineurium, Endoneurium
Term
The outermost layer of connective tissue made mostly of collagen that protects peripheral nerves by limiting the degree to which they can be stretched is known as what?
Definition
Epineurium
Term
The secondmost deep layer of connective tissue covering peripheral nerves that delineate bundles of nerve fibers into fascicles is known as what?
Definition
Perineurium
Term
The perineurium and endoneurium both contribute to what protective barrier that protexts peripheral nerve fibers from exposure to blood-borne toxins?
Definition
Blood-nerve barrier
Term
The innermost layer of connective tissue surrounding individual peripheral axons that is bound internally by the basement membrane of Schwann cells and externally by tight junctions of the perineurium is known as what?
Definition
Endoneurium
Term
What types of nerves are associated with sensory ganglia?
Definition
Several cranial nerves and all spinal nerves located near points where the nerves enter the CNS
Term
What ganglia receive afferent impulses that are relayed to the CNS for processing?
Definition
Sensory ganglia
Term
Sensory ganglia associated strictly with spinal nerves are known as what?
Definition
Dorsal root ganglia
Term
Small neuroglial cells associated with pseudounipolar perikaryon in dorsal root ganglia are called what?
Definition
Satellite cells
Term
What specialized fibroblasts lay down a collagenous capsule that surrounds each perikaryon and its associated satellite cell within dorsal root ganglia?
Definition
Capsule cells
Term
Postganglionic cell bodies of efferent neurons of the autonomic nervous system are found in what ganglia?
Definition
Autonomic ganglia
Term
The functional classification of nervous tissue that includes the motor system controlling glandular secretions and involuntary contraction of smooth and cardiac muscle is known as what?
Definition
Autonomic Nervous System
Term
What is the neurotransmitter used in the synapses between preganglionic and postganglionic fibers in the autonomic nervous system?
Definition
Acetylcholine
Term
Does the autonomic nervous system use direct or indirect effector neurons? 
Definition
Indirect
Term
The "fight or flight" response is initiated by what?
Definition
Sympathetic nervous system
Term
What is the neurotransmitter released by the postganglionic sympathetic neuron?
Definition
Norepinepherine
Term
What is another name for the sympathetic system?
Definition
Throacolumbar division
Term
Where do preganglionic neurons of the sympathetic nervous system originate from?
Definition
Thoracic and upper lumbar segments of the spinal cord
Term
What is the neurotransmitter released at postganglionic parasympathetic nerve endings?
Definition
Acetycholine
Term
Ganglia of the parasympathetic nervous system are found where?
Definition
Near or within the effector organ