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myeloprolif disorders
liek the title
10
Medical
Professional
08/21/2011

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Term
what is jak2 mut
Definition
617 valine to phenyalanine, spontaneous firing of EPO receptor without approrpriate signal
Term
in CML is the germline affected?
Definition
no acquired not congential. only in hematopoetic cell line.
Term
what cell line is the bcr/able mutation in?
Definition
hematopoetic cells
Term
T/F: in essential thrombocytopenia you can have hemmorhage or thrombosis?
Definition
T. platelets can be inactive or too active.
Term
T/F you would expect to see left shift in immature leukocytes in ET?
Definition
F. myelofibrosis
Term
paroxysomal noctural hemogloinuria is a myelodypslastic syndrome?
Definition
F. neither myelodysplastic or myeloproliferative.
Term
myeloproliferative disorder? common findings?
Definition
pancytopenia, hypercellular bone marrow, common in >60, usually die from infection or it becomes AL
Term
what are the major requirements of pvera
Definition
splenomegaly, normal o2 sat >92% and increased RBC
Term
what are the minor requirement of pvera diagnosis and what do you need to diagnose pvera
Definition
-thrombocytosis, leukocytosis, LAP no fever or infection, serum b12, must have all three major criter or increase RBC mass an dnormal o2 sat + 2 minor
Term
T/F paraoxysomal nocturnal HBG is can be cause by aplastic anemia?
Definition
T and false, PNH can cause aplastic, or aplastic can cause PNH
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