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MSK etc
MSK keck
27
Medical
Graduate
05/22/2012

Additional Medical Flashcards

 


 

Cards

Term
Diazepam
Definition
GABA-A agonist --> inhibits NT release --> sedation
Side effect sedation
Term
Baclofen
Definition
GABA-B agonist --> presynaptic --. closes Ca channels --> inhibits NT release
Less sedating than diazepam
Inhibits substance P --> analgesic
Term
Gabapentin
Definition
GABA analogue, but blocks Ca channel --> inhibitory
Spasmolytic
Term
Pregabalin
Definition
(similar to gabapentin)
Ca channel blocker
Used for fibromyalgia
adverse effect = memory deficits (take before bed)
Term
Tizantidine
Definition
Increases pre/postsynaptic inhibition (spasmolytic)
Analgesic
Adverse effects = drowsiness, hypertension, dry mouth
Term
Riluzole
Definition
Glutamate blocker --> inhibits NT release
spasmolytic for ALS tx
Term
Dantrolene
Definition
Binds to ryanodine receptors --> blocks Ca release from SR
No effect on cardiac / smooth muscle
Used to tx malignant hyperthermia (constitutive Ca release)
Term
Botulinum toxin
Definition
blocks vesicular release of ACh --> spasmolytic
Term
Cyclobenzaprine
Definition
Blockade of 5HT2 on dorsal horns --> spasmolytic
Term
Colchicine
Definition
inhibits production of crystal-induced chemotactic factor (CCF) which is released by urate crystals and causes inflammation
- does not have analgesic / anti-pyretic activity
Term
Probenecid / sulfinpyrazone
Definition
Uricosuric, used for chronic/tophaceous gout (only if uric acid under-excreter)
- Competes w/ uric acid binding to organic acid transporter in proximal tubule --> inhibits reabsorption of uric acid --> increases excretion
Term
Allopurinol
Definition
Used for chronic gout in uric acid over-producers
Competes w/ xanthine for xanthine oxidase
-hypoxanthine & xanthine are soluble & excreted renally (as well as allouprinol metabolite, alloxanthine)
Term
MRI weightings - T1 for? T2 for? PD for?
Definition
T1 = anatomy
T2 = pathology
PD = cartilage
Term
Pharm rx for fibromyalgia
Definition
gabapentin / pregabalin
Term
central cord SCI symptoms
Definition
UE deficit > LE
UE = LMN
LE = UMN
distal extremities worse than proximal
Term
Brown sequard SCI symptoms
Definition
contralteral pain/temp 2 segments below
ipsilateral motor / proprioception loss
Term
Anterior cord SCI symptoms
Definition
loss of motor / pain / temp
preserved touch & proprioception (DCML)
poor prognosis
Term
Posterior cord SCI symptoms
Definition
loss of proprioception & light touch
preservation of motor / pain / temp
(foot-slapping gait)
Term
Cervical myelopathy symptoms
Definition
tandem gait difficulty
hyper / hypo reflexes
hoffman's sign
babinski
clonus
Term
Cervical radiculopathy symptoms
Definition
Spurling's test +
LMN signs at level of compression
Term
3 fractures unique to kids
Definition
greenstick
bending
buckle
Term
3 causes of in-toeing
Definition
metatarsus adductus
internal tibial torsion
femoral anteversion
Term
EMG signs carpal tunnel
Definition
a. Increased distal median sensory latency time
b. Increased distal median motor conduction time
c. Early denervation of thenar muscles
Term
types of syndactyly
Definition
1. Complex = bones fused
a. Skin graft can be taken from volar wrist (same color)
2. Simple = no structures fused except skin – can be easily separated
Term
four signs of tendon sheath infections (kanavel)
Definition
1. Diffuse finger swelling
2. Tenderness
3. Finger held in flexed position
4. Excruciating pain w/ extension
Term
bacterial cause of necrotizing fasciitis
Definition
streptococcus
Term
time window for reconstructive surgery
Definition
need to operate in first 6 hours
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