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Morphine Sulfate
drug capsule
12
Pharmacology
03/02/2010

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Cards

Term
Morphine Sulfate - Trade Names
Definition
Astramorph, PF
Term
Morphine Sulfate - Class
Definition
opioid analgesic
Term
Morphine Sulfate - description
Definition

  • natural opium alkaloid
  • primary effect = analgesia
  • increases peripheral venous capitance, decreases venous return (chemical phlebotomy)
  • causes euphoria, respiratory and CNS depression
  • secondary effects = depressed responsiveness to alpha adrenergic receptors (produces peripheral vasodilation) and baroreceptor inhibition
  • decreases pre and afterload, may decrease myocardial O2 demand
  • schedule II drug

Term
Morphine Sulfate - Indications
Definition

  • chest pain associated with MI
  • pulmonary edema w/ or w/out associated pain
  • moderate / severe acute or chronic pain

Term
Morphine Sulfate - Contraindications
Definition

  • hypersensitivity to narc.s
  • hypotension
  • hypovolemia
  • head injury
  • undiagnosed abdominal pain
  • increased ICP
  • severe respiratory depression
  • pt's who have taken MAOI's w/in 14 days

Term
Morphine Sulfate - Onset and Duration
Definition

 

Onset : 1-2 min

 

Duration : 2-7 hours

Term
Morphine Sulfate - Adverse Reactions
Definition

  • hypotension
  • tachycardia / bradycardia
  • palpitations
  • syncope
  • facial flushing, diaphoresis
  • itching
  • respiratory depression
  • euphoria
  • bronchospasm
  • dry mouth
  • allergic rxn

Term
Morphine Sulfate - Drug Interactions
Definition

  • CNS depressants - may potentiate effects (resp. depression, hypotension, sedation)
  • phenothiazines - may pootentiate analgesia
  • MAOI's - may cause paradoxical excitation

Term
Morphine Sulfate - Supply
Definition

  • tablets
  • suppositories
  • solutions
  • IV
  • parenteral preps differ in strength, common in 10 mg in 1 ml sol. ampules and Tubex syringes

Term
Morphine Sulfate - Dosage and Administration

 

Adult

Definition
2-4 mg IV, slowly over 1-5 min, repeat every 5-30 min, titrate to effect
Term
Morphine Sulfate - Dosage and Administration

 

Pediatric

Definition
0.1 - 0.2 mg / kg / dose IV (max 15 mg)
Term
Morphine Sulfate - Special Considerations
Definition

  • pregnancy category B (if not for long periods or at high doses), narc.s rapidly cross placenta
  • safety in neonates is not established
  • caution in elderly, pt's w/ asthma and those susceptible to CNS depression
  • caution in chronic pain syndromes
  • may worsen bradycardia or heart block in inferior MI (vagatonic effect)
  • naloxone should be readily available