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Monoamine Oxidase Inhibitors
Kaplan and Saddock, Synopsis of Psychiatry 10th ed., Section 36.23
7
Medical
Graduate
09/20/2013

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Term
What are the two types of MAOs?
Definition

MAOA primarily metabolized norepinephrine, serotonin and epinephrine.

Dopamine and tyramine are metabolized by both MAOA and MAOB.

Term
What are the five most common adverse effects of MAOIs?
Definition

Orthostatic hypotension

Insomnia

Weight gain

Edema

Sexual dysfunction

Term
How can MAOI-induced paresthesias be treated?
Definition
Pyridoxine supplementation of 50-150mg PO per day.
Term
What are the two absolute CI and three relative CI to MAOI treatment?
Definition

Absolute: thyrotoxicosis, pheochromocytoma

Relative: renal disease, cardiovascular disease, hyperthyroidism

Term
How should a MAOI-induced hypertensive crisis be treated?
Definition
α-adrenergic antagonists (e.g. phentolamine or chlorpromazine)
Term
How does MAOI overdose present?
Definition
1-6 hour asymptomatic period followed by agitation that progresses to coma with ↑T°, ↑BP, ↑P, ↑RR, dilated pupils and hyperactive deep tendon reflexes.
Term
What are the 8 absolutley CI drugs in a patient taking MAOIs?
Definition

Antiasthmatics

Antihypertensives

Buspirone

Levodopa

Opioids

Sympathomimetics

SSRIs

L-tryptophan

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