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Micro 12/11/12 Small DNA Viruses
HDPP final at UMMSM
18
Microbiology
Graduate
12/13/2012

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Term
Parvovirus
Definition
Smallest DNA virus with ssDNA genome and naked icosahedral capsid
Term
Parvovirus
Definition
Can only infect growing cells because cannot induce cell to enter S phase. Entirely dependent on host cell machinery
Term
Parvovirus
Definition
Two genera that can infect humans: erythrovirus B19 and dependovirus
Term
B19 virus
Definition
Enters via respiration and disseminates in blood to cause erythema, rash, pruritus, arthralgia, and erythroid aplasia; can cause spontaneous abortion in pregnant females but is not teratogenic.
Term
B19 virus
Definition
Directly kills erythrocyte precursors and causes febrile exanthema (fifth disease)
Term
B19
Definition
Infection of the fetus of a seronegative mother can result in anemia and congestive heart failure due to RBC destruction
Term
Dependoviruses (AAVs)
Definition
Can be used as vectors in gene therapy. Latently infect non-dividing cells without causing disease and have a specific site of integration
Term
Papovaviruses
Definition
Includes papillomaviruses and polyomaviruses
Term
Papovaviruses
Definition
dsDNA genome in small icosahedral capsid. Can cause lysis or oncogenci transformation by binding to p53 and Rb and transforming cells not permissive to replication
Term
Papillomaviruses (HPV)
Definition
Produce two anti-tumor suppressing proteins, E6 and E7, that bind to p53 and Rb. Sexual transmission, produces warts due to rise of dermal papillae
Term
Papillomaviruses (HPV)
Definition
Different serotypes affect different areas. Protein-based vaccine to prevent cervical cancer, precancerous/dysplastic lesions, and genital warts
Term
Polyomaviruses
Definition
BK and JC only cause disease in immunosuppressed. They enter the RT, multiply and disseminate to the kidney where they become latent. Oncogenic in animals (SV40) mediated by T-antigen
Term
BK virus
Definition
In IC patients, it spreads to the urinary tract, causing hemorrhagic cystitis
Term
JC virus
Definition
Goes to the CNS and causes multifocal leukoencephalopathy (PML) like prions
Term
Adenoviruses
Definition
Linear dsDNA in a naked icosahedral capsid containing fibers at its vertices. Both the capsid and fibers are cytotoxic and produce E1A and E1B, which bind to Rb and p53
Term
Adenoviruses
Definition
Cause lytic, persistent, or latent infections as well as adenoid tumors in animals.
Term
Adenoviruses
Definition
Spread by aerosol or fecal-oral, enter and spread to gut. Cause conjunctivitis, pharyngitis, and gastroenteritis. Hepatitis and meningoencephalitis in IC, children and BMT recipients at risk for acute hemorrhagic cystitis
Term
Adenoviruses
Definition
Infect mucoepithelial cells, replicate in permissive cells, latent in lymphoid tissue. Live attenuated vaccine for two serotypes reserved for military recruits
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