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Mesodermal Centric Perspective Part 2
8/30/11 Second Lecture
6
Medical
Graduate
08/30/2011

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Term
What part of the mesoderm does the cardiovascular system arise from?
Definition
Splanchnic (Subset of the lateral) mesoderm
Term
What structures do the somites give rise to?
Definition
1. Axial skeleton
2. Axial musculature
3. Limb musculature
4. Dermis
Term
What two types of cells border the extracellular matrix most predominantly?
Definition
1. Epithelia
2. Mesenchyme
Term
What is EMT?
Definition
Epithelial Mesenchyme Transformation

A process of cell transition characterized by loss of cell adhesion and increased cell mobility
Term
Give an example of an inductive interaction involved in somite development
Definition
SHH protein is released by the notochord, whose receptors stimulate the release of PAX1, transcription factors that are important in cell differentiation and somite formation
Term
What role do Hox genes play in differentiation of the axial skeleton?
Definition
Different combinations of Hox genes in different segment of the axial skeleton lead to the development of vertebrae with fundamentally different shapes. Hox code is used for cells to read their location in the body.

Ex. lack of Hox10 gene generates growth of ribs on lumbar vertebrae
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