Shared Flashcard Set

Details

Mens Health
Chuanhai Cao Ph.D.
12
Pharmacology
Professional
04/25/2013

Additional Pharmacology Flashcards

 


 

Cards

Term
Finasteride
Definition
Proscar
first approved 5a-reductase inhibitor
as Propecia and is prescribed for both men and women who suffer from hair loss
Term
Dutasteride
Definition
Avodart
amide analog of Finasteride, and the FDA approved it for BPH
Term
Leuprorelin
Definition
Lupron
first LH-RH agonist approved for prostate cancer
peptide, it is only provided as an inject
doses that require injection every 3-6 months. Common side effects include water retention and urinary inconsistencies
Term
Goserelin
Definition
Zoladex
initially pursued as an LH-RH agonist for breast cancer, but was approved for prostate cancer
peptide
injectable, formulated for injection every 28 days or every 3 months
typically causes a “flare up” of initially-increased testosterone production before becoming effective, but it has fewer other side effects than Lupron.
Term
Histrelin
Definition
Vantas
approved for prostate cancer
annual subcutaneous implant. Side effects include hot flashes, and urinary inconsistencies
Term
Triptorelin
Definition
Trelstar
newest LH-RH agonist
powder that must be dissolved prior to injection, which can be conducted every 1-6 months
“flare up” when first injected, but so far appears to have reduced side effects.
Term
Bicalutamide
Definition
Casodex
first androgen receptor agonist that was approved for prostate cancer
is small molecule
only available as a racemic mixture
urinary irregularity and decreased libido
Term
Flutamide
Definition
Casodex
more significant side effects including gynecomastia as well as increased soreness and liver toxicity
Term
Nilutamide
Definition
Nilandron
microcrystalline powder that is taken in pill form
does not show significant CYP inhibition
Term
Sipuleucel-T
Definition
Provenge
vaccine created by collecting a patient’s leukocytes and incubating them with an antigen for a specific enzyme
Term
Enzalutamide
Definition
Xtandi
first drug approved for the treatment of mCRPC
potent inhibitor of CYP2C8
Like most other anti-androgens, urinary inconsistencies and decreased libido are common side effects.
Term
Cabozantinib
Definition
Cometriq
inhibitor of an enzyme known as c-MET that was approved for medullary thyroid cancer
currently in Phase III clinical trials for mCRPC
Supporting users have an ad free experience!