Term
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Definition
Hydrocortisone (Cortisone)
TC: Anti-psoriatic
PC: GR receptor agonist
CC: Steroid (Glucocorticoid)
MOA: Relief of inflammation and pruritis
SAR: Carbonyl at C3
Double bond at C4 and c5
Oxygen substituent at C11
Beta-ketol at C17
Halogenation increasea lipophilicity and potency |
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Term
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Definition
Calcipotriene (Dovonex)
TC: Anti-psoriatic
PC: Vitamin D receptor agonist
CC: Vitamin D analog
MOA: Slows skin cell proliferation |
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Term
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Definition
Permethrin (Nix, Elimite)
TC: Pediculocide/Scabicide
PC: Sodium channel blocker (neurotoxicity)
CC: Pyrethroid |
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Term
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Definition
Tretinoin (Retin-A)
TC: Anti-acne agent
PC: RAR agonist and binds PPAR receptors
CC: Retinoid (Vitamin A derivative)
MOA: Indicated for acne and psoriasis
**Teratogenic
1st generation non-aromatic = Retinol, tretinoin, isotretinoin
2nd Generation mono-aromatic = Acitretin
3rd Generation poly-aromatic = adaplene, tazarotene |
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Term
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Definition
Allopurinol (Zyloprim)
TC: Anti-gout (chronic) agent
PC: XO inhibitor
CC: Purine
MOA: Decrease uric acid production
**DDI between Xo inhibitors and thiopurines and theophylline |
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Term
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Definition
Probenecid (Benemid)
TC: Anti-gout (Chronic)
PC: URAT-1 Inhibitor
CC: Arylsulfonamide
MOA:Increase excretion |
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Term
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Definition
Indomethacin (Indocin)
TC: Anti-inflammatory
PC: COX inhibitor
CC: Arylalkanoic acid
**CV and GI BBW |
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Term
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Definition
Pregabalin (Lyrica)
TC: Analgesic (and anti-epileptic)for fibromyalgia
PC: Alpha2 delta neuronal calcium channel ligand
CC: GABA analog
**CNS related toxicity |
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Term
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Definition
Acetaminophen (Tylenol)
First line therapy – analgesic and NOT an anti-inflammatory
TC: analgesic and antipyretic
PC: COX-3 inhibition at TRPV (vanilloid) / cannabinoid receptors
CC: substituted phenol
**Toxic metabolite NAPQI – hepatotoxicity at high doses |
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Term
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Definition
Acetylsalicylic acid (Aspirin)
TC: analgesic, anti-inflammatory, anti-pyretic and anti-coagulant
PC: Cox non-selective inhibitor
CC: o-hydroxybenzoic acid
SAR: carboxylic acid required for activity
**Acetylated salicylates – covalent and irreversible COX-inhibition |
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Term
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Definition
Meclofenamate (Meclomen)
TC: analgesic and anti-inflammatory
PC: COX non-selective inhibitor
CC: fenamic acid (N-arylanthranilic acid) |
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Term
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Definition
Diclofenac (voltaren)
TC: analgesic and anti-inflammatory
PC: COX non-selective inhibitor
CC: acetic acid (benzacetic) |
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Term
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Definition
Ibuprofen (Motrin)
TC: Analgesic , anti-inflammatory and antipyretic
PC: COX Non-selective inhibitor
CC: propionic acid |
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Term
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Definition
Meloxicam (Mobic)
TC: analgesic and anti-inflammatory
PC: COX inhibitor (non-selective)
CC: oxicam
MOA: COX inhibition and inhibit leukocyte migration |
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Term
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Definition
Celecoxib (Celebrex)
TC: analgesic and anti-inflammatory
PC: Cox-2 selective inhibitor
CC: diaryl-substituted pyrazole |
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Term
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Definition
Methotrexate (Rheumatrex)
TC: immunosuppressant and anti-cancer
PC: DHRF inhibitor (dihydrofolate reductase)
CC: Pteridine |
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Term
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Definition
Teriparatide (rhPTH, Forteo)
TC: Anabolic agent
PC: PTH analog
MOA: stimulates osteoblast activity by binding PTHrP used SC. Used Second line for OP
BBW: risk of steosarcoma |
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Term
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Definition
Calcium Citrate
TC: Anti-resorptive agents
PC: Calcium supplement
** Better absorbed than other calcium salts in low acid conditions (PPI therapy)
Should always be taken in with VIT D |
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Term
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Definition
Cholecalciferol (vitamin D3)
TC: Anti-resorptive
PC: Vitamin D analogs
RX Approved for use in treatment of OP |
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Term
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Definition
Aldendronate (Fosamax)
TC: Anti-resorptive
PC: Bisphosphonate (analogs of pyrophosphate)
First line therapy for prevention and treatment of OP
MOA: N containing – block rate limiting step in cholesterol synthesis pathway used in osteoclast function, Non-N containing – block tRNA synthetase leading to osteoclast apoptosis
ADR: Osteonecrosis of the jaw, bone/joint/muscle pain |
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Term
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Definition
Raloxifene (Evista)
TC: Anti-resorptive
PC: SERM (selective estrogen receptor modulators, ER-B)
Used in treatment and prevention of OP. Second line for OP in women
BBW: increased risk of VTE and stroke |
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Term
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Definition
Cyclobenzaprine (Flexeril, Amrix)
TC: Centrally acting Spasmolytic
PC: Anti-cholnergic, action in the brain stem
CC: dibenzocycloheptene |
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Term
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Definition
Diazepam (Valium)
TC: Centrally acting Spasmolytic
PC: GABA receptor agonist at spinal and supraspinal sites
CC: Benzodiazepine |
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Term
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Definition
Botulinum toxins A(Botox, Dysport) B(Myobloc)
TC: Direct acting spasmolytic
PC: Cleavage of SNAP-25
CC: Protein |
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Term
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Definition
Succinylcholine chloride (Anectine)
TC: Neuromuscular blocking agent
PC: Depolarizing
CC: bis-quaternary amine
*Shortest duration of action |
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Term
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Definition
Pancuronium Bromde (Pancuron)
TC: Neuromuscular blocking agent
PC: Non-depolarizing
CC: Steroid based
*Longest duration of action |
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Term
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Definition
Metocurine iodide (Metubine)
TC: Neuromuscular blocking agent
PC: Non-depolarizing
CC: Tetrahydroisoquinoline, Non-steroid based
*Long duration of action |
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Term
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Definition
Antipyrine (Auralgan Otic Drops)
TC: Anti-inflammatory
PC: Cox3 selective |
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Term
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Definition
Naproxen (Aleve)
TC: Anti-inflammatory |
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