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MASTER - Depression Drugs
Psychiatric Nursing - FSCJ Nursing program 2012
36
Nursing
Undergraduate 3
02/20/2012

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Term
Selective Serotonin Reuptake Inhibitors (SSRIs)examples
Definition
Citalopram (Celexa)

Escitalopram (Lexapro)

Fluoxetine (Prozac)

Fluvoxamine (Luvox)

Paroxetine (Paxil)

Sertraline (Zoloft)
Term
irst line of treatment for major depression?
Definition
Selective Serotonin Reuptake Inhibitors (SSRIs)
Term
Selective Serotonin Reuptake Inhibitors (SSRIs) side effects
Definition
Agitation, insomnia, headache, nausea and vomiting, sexual dysfunction, and hyponatremia
Term
Selective Serotonin Reuptake Inhibitors (SSRIs) contraindications ?
Definition
Contraindicated in people taking MAOIs
Term
"Herbal" SSRI like medication taken by many?
Definition
St. Johns Wart
Term
Serotonin Norepinephrine Reuptake Inhibitors (SNRIs)examples
Definition
Venlafaxine (Effexor)

Duloxetine (Cymbalta)
Term
Serotonin Norepinephrine Reuptake Inhibitors (SNRIs)side effects
Definition
Hypertension (venlafaxine), nausea, insomnia, dry mouth, sweating, agitation, headache, sexual dysfunction
Term
Serotonin Norepinephrine Reuptake Inhibitors (SNRIs) contraindications
Definition
Contraindicated in people taking MAOIs
Term
what is cymbalta's advantage over effexor?
Definition
Cymbalta has the advantage of decreasing neuropathic pain
Term
which SNRI is usually tried after SSRI's failed?
Definition
Venlafaxine (Effexor)
Term
Norepinephrine Reuptake Inhibitors (NRIs)example?
Definition
Reboxetine (Vestra)
Term
Norepinephrine Reuptake Inhibitors (NRIs)side effects?
Definition
Insomnia, sweating, dizziness, dry mouth, constipation, urinary hesitancy, tachycardia, decreased libido
Term
Norepinephrine Reuptake Inhibitors (NRIs) contraindications?
Definition
Contraindicated in people taking MAOIs
Term
Norepinephrine Reuptake Inhibitors (NRIs) main use?
Definition
Antidepressant effects similar to SSRIs and TCAs

Useful with severe depression and impaired social functioning
Term
Serotonin Receptor Antagonists/Agonists (SRA) example
Definition
Nefazodone (formerly sold as Serzone)
Term
Serotonin Receptor Antagonists/Agonists (SRA)side effects
Definition
Sedation, hepatotoxicity, dizziness, hypotension, paresthesias
Term
Serotonin Receptor Antagonists/Agonists (SRA)contraindications
Definition
Contraindicated in people taking MAOIs
Term
Serotonin Receptor Antagonists/Agonists (SRA)benefits over an SSRI
Definition
Lower risk of long-term weight gain than SSRIs or TCAs

Lower risk of sexual side effects than SSRIs
Term
Norepinephrine Dopamine Reuptake Inhibitor (NDRI)example
Definition
Bupropion (Wellbutrin)
Term
Norepinephrine Dopamine Reuptake Inhibitor (NDRI)side effects
Definition
Agitation, insomnia, headache, nausea and vomiting, seizures (0.4%)
Term
Norepinephrine Dopamine Reuptake Inhibitor (NDRI)contraindications
Definition
Contraindicated in people taking MAOIs

High doses increase seizure risk, especially in people who are predisposed to them
Term
Norepinephrine Dopamine Reuptake Inhibitor (NDRI)benefits?
Definition
Stimulant action may reduce appetite

May increase sexual desire

Used as an aid to quit smoking
Term
Serotonin Norepinephrine Disinhibitors (SNDIs)example
Definition
Mirtazapine (Remeron)
Term
Serotonin Norepinephrine Disinhibitors (SNDIs)uses
Definition
Antidepressant effects equal SSRIs and may occur faster
Term
Serotonin Norepinephrine Disinhibitors (SNDIs)side effects
Definition
Weight gain, sedation, dizziness, headache; sexual dysfunction is rare
Term
Serotonin Norepinephrine Disinhibitors (SNDIs)warnings and contraindications
Definition
Drug-induced somnolence exaggerated by alcohol, benzodiazepines, and other CNS depressants

Contraindicated in people taking MAOIs
Term
Tricyclic Antidepressants (TCAs)examples
Definition
Amitriptyline (Elavil)

Clomipramine (Anafranil)

Desipramine (Norpramin)

Doxepin (Adapin, Sinequan)

Imipramine (Tofranil)

Nortriptyline (Aventyl, Pamelor)

Protriptyline (Vivactil)
Term
Tricyclic Antidepressants (TCAs)uses
Definition
Therapeutic effects similar to SSRIs, but side effects are more prominent

May work better in melancholic depression TCAs can worsen many cardiac and medical conditions
Term
Tricyclic Antidepressants (TCAs)side effects
Definition
Dry mouth, constipation, urinary retention, blurred vision, orthostatic hypotension, cardiac toxicity, sedation
Term
Tricyclic Antidepressants (TCAs)cautions and contraindications
Definition
Lethal in overdose

Use cautiously in older adults and those with cardiac disorders, elevated intraocular pressure, urinary retention, hyperthyroidism, seizure disorders, and liver or kidney dysfunction.

Contraindicated in people taking MAOIs
Term
Tricyclic Antidepressants (TCAs)are normally taken after which group of drugs fails?
Definition
SSRI/SNRI
Term
Monoamine Oxidase Inhibitors (MAOIs)examples
Definition
Phenelzine (Nardil)

Selegiline Transdermal System Patch (EMSAM)

Tranylcypromine (Parnate)
Term
Monoamine Oxidase Inhibitors (MAOIs)uses
Definition
Efficacy similar to other antidepressants, but dietary restrictions and potential drug interactions make this drug less desirable
Term
Monoamine Oxidase Inhibitors (MAOIs)side effects
Definition
Insomnia, nausea, agitation, and confusion

Potential for hypertensive crises or serotonin syndrome with concurrent use of other antidepressants
Term
Monoamine Oxidase Inhibitors (MAOIs)warnings and contraindications
Definition
Contraindicated in people taking other antidepressants

Tyramine-rich food could bring about a hypertensive crisis

Many other drug interactions
Term
serotonin syndrome symptoms
Definition
• Hyperactivity or restlessness

• Tachycardia → cardiovascular shock

• Fever → hyperpyrexia

• Elevated blood pressure

• Altered mental states (delirium)

• Irrationality, mood swings, hostility

• Seizures → status epilepticus

• Myoclonus, incoordination, tonic rigidity

• Abdominal pain, diarrhea, bloating

• Apnea → death
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