Term
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Definition
Only parenteral drug available in US since 1991.
Mechanism-Inhibit the polymerization of heme molecues w/in parasite vacuoles. Heme is very toxic, causing oxidative damage to membranes and digestive proteases.
Resistance-transporter mutation pumps chloroquine out of vacuole. |
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Term
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Definition
Mechanism-Inhibit the polymerization of heme molecues w/in parasite vacuoles. Heme is very toxic, causing oxidative damage to membranes and digestive proteases.
Resistance-transporter mutation pumps chloroquine out of vacuole. |
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Term
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Definition
Mechanism-Inhibit the polymerization of heme molecues w/in parasite vacuoles. Heme is very toxic, causing oxidative damage to membranes and digestive proteases.
Resistance-transporter mutation pumps chloroquine out of vacuole.
Neurotoxicity & psychoses |
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Term
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Definition
Only drug available to tx relapses/latent infxns.
CAUTION: primaquine depletes glutathione reserves; individuals w/ glucose-6-phosphate dehydrogenase deficiency are at great risk for hemolysis/anemia!!! |
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Term
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Definition
| Dihydrofolate Reductase Inhibitor |
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Term
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Definition
| Dihydrofolate Reductase Inhibitor |
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Term
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Definition
| Dihydrofolate Reductase Inhibitor (actually interferes w/ tetrahydrofolate synthesis earlier in pathway). |
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Term
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Definition
Depolarizes parasitic mitochondria & inhibits their electron transport (low incidence of resistance).
Used in combo w/ Proguanil |
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Term
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Definition
| Mech: inhibits parasite SERCA of P. falciparum |
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Term
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Definition
| Mech: inhibits parasite SERCA of P. falciparum |
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Term
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Definition
| Similar to chloroquine; available as an alternative to chloroquine. |
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Term
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Definition
| inhibits protein translation. |
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Term
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Definition
| inhibits protein translation. |
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Term
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Definition
| inhibits protein translation. |
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Term
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Definition
Dihydrofolate Reductase Inhibitor
used in combination w/ atovaquone |
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Term
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Definition
Use-Schistosomiasis
Mechanism-increases permeability of worm to Ca2+, causing contractions and paralysis of worm musculature -> outer membran breaks down -> host immune response.
Side Effects-some abdominal discomfort & head ache, but quite safe. |
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Term
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Definition
aka benflumetol; synthesized in China.
used in combination w/ artemether called coartemether.
other than that, was not discussed much. |
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Term
| Proguanil with Atovaquone |
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Definition
| Used prophylactivally and to tx active infx with Plasmodium falciparum, including chloroquine resistant strains. |
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