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Lymphomas
Clinical Medicine Test 5
13
Medical
Graduate
11/07/2010

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Cards

Term
What are some risk factors for Hodkin's disease?
Definition
1) Males
2) 10x risk w/ same sex sibling
Term
What is considered to be the malignant cell of Hodkin's disease?
Definition
Reed-Sternberg cell, a multinucleate giant cell
Term
4 subtypes of Hodkin's disease and most common one?
Definition
1) Lymphocyte predominance
2) Nodular Sclerosis - most common
3) Mixed Cellularity
4) Lymphocyte depletion
Term
4 subtypes of Hodkin's disease and most common one?
Definition
1) Lymphocyte predominance
2) Nodular Sclerosis - most common
3) Mixed Cellularity
4) Lymphocyte depletion
Term
What is the most common presenting clinical feature of Hodkin's disease?
Definition
painless lymph node enlargement
Term
What are the first signs of subdiaphragmatic disease in Hodkin's disease?
Definition
Spleen and lymph nodes in the celiac axis
Term
Who are more likely to have widespread disease with a worse prognosis?
Definition
1) HIV infected
2) Elderly
3) developing countries
Term
What is essential for diagnosis in Hodkin's disease?
Definition
lymph node biopsy
Term
What is the tool of choice for diagnosing occult spleen enlargement in Hodgkin's disease?
Definition
Exploratory laprarotomy
Term
Staging and prognosis for Hodgkin's disease
Definition
stage 1-single LN involvement
stage 2-involvement of 2 or more LN regions on the same side of the diaphragm
stage 3-involvement of LN on both sides of diaphragm
stage 4-Involvement of one more extranodal sites
Term
What is used to treat Hodgkin's disease in most cases?
Definition
Chemotherapy
Term
What is the single most important test for diagnosing Non-hodgkin's lymphoma?
Definition
properly evaluated and technically adequate biopsy
Term
What are 5 adverse risk factors for prognosis in Non-hodgkin's lymphoma?
Definition
1) Age >60
2) Stage III/IV disase
3) 2 or more extranodal sites
4) performance status >2
5) increased LDH
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