Shared Flashcard Set

Details

Lung Cancer Treatments
Therapy Final
14
Pharmacology
Graduate
12/07/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
Cisplatin (Platinol)
Definition
highly emetogenic, ototoxic, renal toxicity
Term
Carboplatin (Paraplatin)
Definition
Emetogenic, renal toxicity: use calvert formula for dosing
Term
Platinum agents
Definition
can be interchangeable, cause anticipatory N/V; use zofran
Term
Oxalipatin (Eloxatin)
Definition
not used in lung cancer, mostly for colon
Term
Paclitaxel (Taxol)
Definition
moderately emetogenic; dose dependent
and can be neurotoxic. Does q3wk vs. weekly
Term
Docetaxol (Taxotere)
Definition
better tolerated, careful dosing, from needles of Euu
Term
Etoposide (Vespid, VD-16)
Definition
mildly emetogenic, severe hypotension with rapid infusion
Term
Vinblastine (Velban)
Definition
vinca alkyloid; neurotoxic and fatal if injected intrathecally
Term
vinorelbine (navelbine)
Definition
vinca alkyloid; neurotoxic and fatal if injected intrathecally
Term
vinca alkyloids
Definition
do not inject intrathecally, other agents are administered this way. irreversible and deadly mistake especially to children
Term
tyrosine kinase inhibitors
Definition
cyp3A4 metabolized, many drug interactions and causes rashes
Term
Erlontanib (tarceva)
Definition
2nd/3rd line, improves OS by 3.3 months
Term
Crizotinib (Xalkori)
Definition
Treats NSCLC that is advance or metastasized; caused by defect in ALK gene
Term
Pemetrexed (Altima)
Definition
inhibits several enzymes of folate synthesis; avoid with NSAID; do not use if CrCl is less than 45
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