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Lecture 5
The Synapse
16
Physiology
Undergraduate 2
02/13/2011

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Term
gap junctions
Definition
form direct cytoplasmic connections b/w adjacent cells
Term
contact dependent signals
Definition
require interaction between membrane molecules
Term
myasthenia gravis
Definition
not enough receptors-treat by inhibiting enzyme that breaks down Ach
Term
ionotropic
Definition
ion channel pore
Term
metabotropic
Definition
-indirectly linked with ion channels on plasma membrane
-g protein coupled receptor
-amplification
Term
cAMP
Definition
-olfactory
-activates protein kinases (A)
-binds to ion channels
-phosphorylates proteins
-alters channel opening
Term
cGMP
Definition
-vision
-activates protein kinases (G)
-binds to ion channels
-phosphorylates proteins
-alters channel opening
Term
metabotropic receptors cAMP pathway
Definition
-adenylyl cyclase (amplifier enzyme) turned on by G protein
-converts ATP to cAMP
-kinase A phosphorylates other proteins leading to a response
Term
ryanodine receptors
Definition
cause Ca release in muscle
Term
postsynaptic membrane and receptors
Definition
receptor numbers
permeability
degradation rates
Term
Ach
Definition
-nicotinic-ICR
-muscarinic-GPCR
Term
amines
Definition
norepinephrine
dopamine
serotonin
Term
Parkinsons
Definition
dopaminergic cells dying
Term
depression
Definition
need more serotonin
Term
glutamate
Definition
excitatory (AMPA/NMDA)
Term
GABA/glycine
Definition
inhibitory (open CL channels)
make GABA receptors work better for anxiety problems
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