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IT
Exam 2
61
Pharmacology
Professional
09/16/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
Cyp2d6 drugs affected(2 class)
Definition
Antidepressants, Anti-psychotics
Term
CYP2D6 PRODRGUS(2)
Definition
Codeine, Tamoxifen
Term
CYP2C9(4)
Definition
Warfarin, NSAIDs, Phenytoin, Tolbutamide
Term
Cyp2c19 Drugs(2)
Definition
Mephenytoin, Omeprazole
Term
Cyp2c19 Prodrug(1)
Definition
Clopidegrel
Term
Aldehyde Dehydrogenase impairment
Definition
Causes facial flushing with alcohol
Term
Pseudocholinesterase(Butyrylcholinesterase)impairment
Definition
Results in prolonged muscle relaxant response to succinylcholine
Term
N-acetyltransferase impairment
Definition
Associated with higher risk of neurotoxicity in isoniazid
Term
Thiopurine S-methyltransferase
Definition
Higher risk of hematopoietic toxicity for azathiopurine & 6-mercaptopurine
Term
UDP-glucuronosyl-transferase lower expression
Definition
Higher risk of toxicity for irinotecan
Term
Glutathione S-transferase
Definition
Higher risk of toxicity with various anti-cancer drugs
Term
P-glycoprotein(ABCB1)
Definition
Affects toxicity of anti-cancer drugs, digoxin, and other drugs
Term
Organic Anion transporters
Definition
Affects statins and methotrexate
Term
Organic cation transporters
Definition
Therapeutic effect of metformin
Term
Vitamin K epoxide reductase
Definition
Warfarin
Term
Thymidylate synthase and methylenetetrahydrofolate reductase
Definition
Affect methotrexate adverse effects
Term
m1 receptor
Definition
Gq, increases intracellular calcium, predominate in CNS
Term
m2 receptor
Definition
Gi opening of K+ channels and reduction in cAMP and predominates in myocardium
Term
m3 Receptor
Definition
Gq, increases intracellular calcium, subtype predominates in exocrine glands, vascular endothelium, & smooth muscle
Term
m4 receptor
Definition
Gi opening of K+ channels and reduction in cAMP and predominates in CNS
Term
m5 receptor
Definition
Gq, increases intracellular calcium, predominates in vascular endothelium of cerebral vessels
Term
a1 receptor
Definition
Gq, increases intracellular calcium, predominates in smooth muscle-including most vascular smooth muscle
Term
a2 receptor
Definition
Gi opening of K+ channels and reduction in cAMP, inhibitory autoreceptor on pre-synaptic nerve terminals, predominates on platelets, adipocytes, and smooth muscle
Term
All beta signal
Definition
through Gs AND elevation of cAMP
Term
b1(location)
Definition
predominates on heart and renal tubules
Term
b2(location)
Definition
predominates in lung and various types of smooth muscle
Term
b3(location)
Definition
predominates in adipocytes
Term
Sympathetic mediated by B1(heart)
Definition
increased heart rate and force of contraction
Term
Sympathetic mediated by B1 and m3(blood)
Definition
increased blood flow to skeletal muscle
Term
Sympathetic mediated by a1(skin)
Definition
decreased blood flow to skin and viscera
Term
Sympathetic mediated by B2(lung)
Definition
relaxation of bronchiolar smooth muscle
Term
Sympathetic mediated by a1(eyes)
Definition
Opening of pupil in eyes
Term
Sympathetic mediated by B2 and a1(sugar)
Definition
Increased gluconeogenesis and glycogenolysis in liver
Term
Sympathetic mediated by B3(fat)
Definition
increased lipolysis in fat cells
Term
Sympathetic mediated by B1(kidney)
Definition
increased renin release from kidney
Term
Parasympathetic mediated by m2(heart)
Definition
reduced heart rate, minimal effect on force of contraction
Term
Parasympathetic mediated by m3(lung)
Definition
contraction of bronchiolar smooth muscle
Term
Parasympathetic mediated by m3(eyes)
Definition
constriction of pupils in eyes and accomadation
Term
Acetylcholine
Definition
short-acting and non-selective direct acting cholinergic agonist
Term
Methacholine
Definition
short-acting and selective direct acting cholinergic agonist
Term
Carbachol
Definition
long acting, non-selective direct acting cholinergic agonist, primarily for glaucoma
Term
bethanechol
Definition
long acting, selective direct acting cholinergic agonist
Term
Direct acting Cholinergic agonist effects
Definition
Vasodilation, increase in heart rate, eye contraction,stimulate secretion, relax sphinter
Term
Indirect acting cholinergic agonist effects
Definition
Vasodilation, decrease in heart rate, eye contraction,stimulate secretion, relax sphinter
Term
Edrophonium
Definition
short acting indirect acting cholinergic agonists
Term
Neostigmine
Definition
long acting indirect acting cholinergic agonists
Term
Cholinergic antagonists effect
Definition
Inhibit secretion, relax muscles and contract sphincter, slight tachycardia
Term
Phenylephrine
Definition
primarily used as nasal decon, vasoconstriction, increases systolic and diastolic BP, decreases HR
Term
Midodrine
Definition
primarily use in OH
vasoconstriction, increases systolic and diastolic BP, decreases HR
Term
a1 adrenoreceptor agonist
Definition
vasoconstriction, increases systolic and diastolic BP, decreases HR
Term
a2 adrenoreceptor agonist
Definition
suppresion of sympathetic tone, reduction in blood pressure
Term
clonidine
Definition
a2 adrenoreceptor agonist, primary therapeutic use in hypertension
Term
B1 adrenoreceptor agonist
Definition
increase inotropic and chronotropic effect on heart, increased cardiac output
Term
dobutamine
Definition
B1 adrenoreceptor agonist, primary therapeutic use in acute heart failure
Term
B2 adrenoreceptor agonist
Definition
relaxation of bronchial smooth muscle, vasodilation and mild increase in heart rate and force of contaction
Term
Albuterol
Definition
B2 adrenoreceptor agonist, primary use in asthma and COPD
Term
a1 adrenoreceptor antagonist
Definition
vasodilation, decreases venous tone, decreases arterial pressure-primarily affects diastolic pressure, relaxes smooth muscles in prostrate,
Term
Prazosin
Definition
a1 adrenoreceptor antagonist, primary therapy to prevent urinary retention with hyperplasia of prostate
Term
B1 adrenoreceptor antagonist
Definition
negative I and C effect(decreases cardiac output), acute effect- increases peripheral resistance, chronic effect is decrease peripheral resistane, leads to decreased BP, suppreses renin release, also reduces intraocular pressue affecting glaucoma
Term
Propranolol
Definition
B1 adrenoreceptor antagonist, affects both B receptors so problematic in asthma patients
Term
Metoprolol
Definition
B1 adrenoreceptor antagonist,more selective than propranolol
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