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IP2 test 2 Drugs
drugs and stuff
107
Pharmacology
Professional
03/05/2012

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Term
Statins
Definition
Lowering plasma cholesterol levels in all types of hyperlipidemias.
Term
Cholestyramine
Definition
They are the drugs of choice (in
combination with low-fat diet or
niacin) in treating type IIA and IIB
hyperlipidemias.
Term
Colestipol
Definition
They are the drugs of choice (in
combination with low-fat diet or
niacin) in treating type IIA and IIB
hyperlipidemias.
Term
Clofibrate
Definition
For the treatment of
hypertriglyceridemia (type IV and V).
• Useful in patients with mixed
hyperlipidemia (type IIB).
• To increase HDL cholesterol levels in
patients with HDL deficiency
Term
Gemfibrozil
Definition
For the treatment of hypertriglyceridemia (type IV and V).
• Useful in patients with mixed
hyperlipidemia (type IIB).
• To increase HDL cholesterol levels in
patients with HDL deficiency
Term
Niacin
Definition
Most effective single drug in the
treatment of mixed hyperlipidemia
(type IIB) and hyperlipoproteinemia
(type IV), in which both VLDL and
LDL are elevated.
It is the most potent antihyperlipidemic agent for raising
plasma HDL levels.
Term
Probucol
Definition
Useful in the treatment of Type IIA and
IIB hypercholesterolemia. It’s usefulness is limited to instances in which other antihyperlipidemic agents
are ineffective.
Term
Warfarin
Definition
Long-term management of patients with deep venous thromboembolism (VTE) or atrial fibrillation or artificial heart valve
Term
Unfractionated heparin
Definition
Preoperative prophylaxis against deep vein thrombosis (VTE).
Administered following MI or
pulmonary embolism (PE).
Heparin prevents clotting in arterial and heart surgery, during blood transfusion, and in renal
dialysis and blood sample collection (in vitro
effect).
Used for initiation of anticoagulation therapy.
Can be used in pregnancy.
Term
Low-molecular-weight heparins
Definition
Inhibit factor IIa and factor Xa
Term
Lipirudin
Definition
Recombinant DNA-derived polypeptide.
in the treatment of deep vein
thrombosis (DVT) and heparin-induced
thrombocytopenia (HIT).
Term
Agatroban
Definition
synthetic molecule that reversibly binds to thrombin.
in the treatment of heparininduced
thrombocytopenia (HIT).
Term
Aspirin
Definition
Decrease thromboxane A2 production in platelets
Term
Ticlopidine
Definition
It inhibits adenosine diphosphate (ADP)-induced expression of platelet glycoprotein receptors and reduces fibrinogen binding to platelets.
Term
Abciximab
Definition
It is Fab fragment of a chimeric human-murine monoclonal antibody.
It is used solely for the prevention of
thrombosis in patients undergoing coronary
angioplasty.
It binds to platelet glycoprotein IIb/IIIa receptors (GP IIb/IIIa) and prevents binding by fibrinogen, and consequently, aggregation
does not occur.
• Eptifibatide and tirofiban, act similarly to abciximab by blocking the GP IIb/IIIa receptor.
Term
Alteplase
Definition
Fibrinolytic Drug
Recombinant forms of human tissue plasminogen activator (t-PA)
Term
Urokinase
Definition
Fibrinolytic Drug
Protein obtained from human urine
Term
Streptokinase
Definition
Fibrinolytic drug
A protein obtained from streptococci
Term
Anistreplase
Definition
Fibrinolytic drug
complex of streptokinase and plasminogen
Term
Diphenhydramine
Definition
H1 Blocker (1st gen)
Allergic Conditions, Motion Sickness
Vertigo, Sedation, NOT the drug of choice for acute anaphylaxis
Term
Clemastine
Definition
H1 Blocker (1st gen)
Allergic Conditions, Motion Sickness
Vertigo, Sedation, NOT the drug of choice for acute anaphylaxis
Term
Chlorpheniramine
Definition
H1 Blocker (1st gen)
Allergic Conditions, Motion Sickness
Vertigo, Sedation, NOT the drug of choice for acute anaphylaxis
Term
Acrivastine
Definition
H1 Blocker (2nd gen)
Allergic Conditions, Motion Sickness
Vertigo, Sedation, NOT the drug of choice for acute anaphylaxis
Term
Cetirizine
Definition
H1 Blocker (2nd gen)
Allergic Conditions, Motion Sickness
Vertigo, Sedation, NOT the drug of choice for acute anaphylaxis
Term
Loratadine
Definition
H1 Blocker (2nd gen)
Allergic Conditions, Motion Sickness
Vertigo, Sedation, NOT the drug of choice for acute anaphylaxis
Term
Fexofenadine
Definition
H1 Blocker (2nd gen)
Allergic Conditions, Motion Sickness
Vertigo, Sedation, NOT the drug of choice for acute anaphylaxis
Term
Desloratadine
Definition
H1 Blocker (3rd gen)
Term
Cimetidine
Definition
H2 Blocker
Inhibits gastric acid production. Promote healing of gastric and duodenal
ulcers. Treat GERD and for
prophylaxis of stress ulcers
Used for Hives
Term
Ranitidine
Definition
H2 Blocker
Inhibits gastric acid production. Promote healing of gastric and duodenal
ulcers. Treat GERD and for
prophylaxis of stress ulcers
Term
Famotidine
Definition
H2 Blocker
Inhibits gastric acid production. Promote healing of gastric and duodenal
ulcers. Treat GERD and for
prophylaxis of stress ulcers
Term
Nizatidine
Definition
H2 Blocker
Inhibits gastric acid production. Promote healing of gastric and duodenal
ulcers. Treat GERD and for
prophylaxis of stress ulcers
Term
Sumatriptan
Definition
5 HT1 agonist
Acute migraine NOT for prophylaxis
Term
Methysergide
Definition
5 HT2 antagonist
Prophylactic migraine and vascular headaches. GI effects of carnicoid tumors
Term
Ondansetron
Definition
5 HT3 antagonist
Nausea
Term
Alosetron
Definition
5 HT3 antagonist
Can be used for schizophrenia, alcoholism and opioid addiction
Term
Metaclopramide
Definition
5 HT4 agonist
Nausea and GI dysmotility
Class used for GERD and IBS
Term
Cisapride
Definition
5 HT4 agonist
Nausea and GI dysmotility
Class used for GERD and IBS
Term
15-methyl PGF2
Definition
Induce abortion in the second
trimester
Postpartum hemostasis
Term
PGE1
Definition
treat ED
Term
Misoprostol
Definition
Nsaid induced gastric ulcer
abortifacient w/ RU486 or methotrexate
Term
PGE2
Definition
Cervical ripening (gel)
Midtrimester abortion (supp)
Term
Zafirlukast
Definition
Leukotriene receptor antagonist
asthma
Term
Zileuton
Definition
5-lipoxygenase inhibitors
Asthma
Term
Aspirin
Definition
Cox-1/Cox-2 inhibitor
Anti-inflammatory, Analgesic, anti-pyretic
Preventin of colon cancer
Bartters syndrome
Promote closure of the ductus
arteriosis
Antiplatelet
Term
Indomethacin
Definition
Cox-1/Cox-2 inhibitor
Anti-inflammatory, Analgesic, anti-pyretic
Preventin of colon cancer
Bartters syndrome
Promote closure of the ductus
arteriosis
Term
Ibuprofen
Definition
Cox-1/Cox-2 inhibitor
Anti-inflammatory, Analgesic, anti-pyretic
Preventin of colon cancer
Bartters syndrome
Promote closure of the ductus
arteriosis
Term
Naproxen
Definition
Cox-1/Cox-2 inhibitor
Anti-inflammatory, Analgesic, anti-pyretic
Preventin of colon cancer
Bartters syndrome
Promote closure of the ductus
arteriosis
Term
Celecoxib
Definition
Cox-2 selective inhibitor
Cox-1/Cox-2 inhibitor
Anti-inflammatory, Analgesic, anti-pyretic
Preventin of colon cancer
Bartters syndrome
Promote closure of the ductus
arteriosis
Term
Acetaminophen
Definition
Cox-3 inhibitory
Analgesic, anti-pyretic
Term
Prednisone
Definition
anti-inflammatory glucocorticoid
block induction of COX-2 at the transcription level
Term
Dexamethasone
Definition
Can be used as an adjunct to reduce nausea in patients with widespread cancer by reducing inflammation
Term
Probenicid
Definition
Treatment of gout
Blocks transport of organic acids across the renal tubule, resulting in increased excretion
Term
Colchicine
Definition
Anti-mitotic. Binds to tubulin.
Treatment of gout by preventing the migration of granulocytes (and other inflammatory cells) into inflamed area
Term
Allopurinol
Definition
Treatment of Gout
Inhibits Xanthine oxidase, which converts xanthine to uric acid
Term
Methotrexate
Definition
Treatment of rheumatoid arthritis
First line DMARD. Folic acid antagonist. Decrease inflammatory cells in the synovium. Reduces RA symptoms and slows joint damage
Term
Hydroxycholoroquine
Definition
Treatment of RA
Anti-malarial drug that shows efficacy as a DMARD. Mechanism not clear
Term
Sulfasalizine
Definition
Treatment of RA
Reduces symptoms and joint damage but less effective than methotrexate. used in triple therapy
Term
Leflunomide
Definition
Treatment of RA
Efficacy cimilar to methotrexate, but MOA not entirle elucidated.
Term
Etanercept
Definition
TNF inhibitor, Treatment of RA
Recombinant protein that binds to circulating TNF
Term
Infliximab
Definition
TNF inhibitor, Treatment of RA
monoclonal antibody that binds TNF
Term
Adalimumab
Definition
TNF inhibitor, Treatment of RA
monoclonal antibody against TNF. "humanized"
Term
Gold Compounds
Definition
These have minimal anti-inflammatory effects in other situations, but cause reductions in the inflammation associated with RA
Term
Abatacept
Definition
Treatment of RA
T-cell costimulatory blocker that interferes with interactions between antigen-presenting cells and T lymphocytes by binding to CD28.
Term
Rituximan
Definition
Treatment of RA
Causes B cell depletion. Monoclonal antibody that binds to CD20 on B cells.
Term
Anakinra
Definition
Treatment of RA
Recombinant IL-1 receptor antagonist.
Term
Azathioprine
Definition
Treatment of RA
Purine analog that inhibits purine synthesis. Anti-mitotic
Term
Cyclosporine A
Definition
Treatment of RA
Immune suppressant drug in transplant recipients.
Term
Cyclophosphamide
Definition
Treatment of SLE
An alkylating agent that is also used in cancer chemotherapy.
Term
Omeprazole
Definition
PPI
Promote healing of gastric and duodenal ulcers and treat GERD that is unresponsive to H2 antagonist
Term
lansoprazole
Definition
PPI
Promote healing of gastric and duodenal ulcers and treat GERD that is unresponsive to H2 antagonist
Term
Rabeprazole
Definition
PPI
Promote healing of gastric and duodenal ulcers and treat GERD that is unresponsive to H2 antagonist
Term
Pantoprazole
Definition
PPI
Promote healing of gastric and duodenal ulcers and treat GERD that is unresponsive to H2 antagonist
Term
Sucralfate
Definition
Creates a sticky gel that adheres to epithelial cells in a protective manner. Treats duodenal ulcers and for prophylaxis of stress ulcers
Term
misoprostol
Definition
Synthetic PGE1 analog, inhibits adenylate cyclase. Prevents NSAID-induced mucosal injury.
Term
sulfasalazine
Definition
Cleaved in the colon by bacterial enzymes to mesalamine (5-ASA) and sulfapyradine. 5-ASA inhibits both cox and 5-lipoxygenase pathways to treat ulcerative collitis, but NOT for Crohn's disease.
Term
lubriprostone
Definition
Calcium channel activator
PGE1 analog, but directly acts on ClC-2 chloride channels. Considered a laxative product, increases fluid secretion in the SI by activating Cl channels.
Term
mesalazine
Definition
Active moeity of sulfasalazine, avoiding the side effects of sulfapyridine.
Term
alosetron
Definition
5-HT3 antagonist. Therapeutic effect in IBS
Term
tegaserod maleate
Definition
5-HT4 partial agonist
Prokinetic agent for therapy of IBS with constipation, particularly in women. Withdrawn due to suggesting increased cardiovascular risk.
Term
loperamide
Definition
inhibit GI motility via opioid receptors on nerve and muscle. Does not cross the BBB and effective against travelers diarrhea
Term
psyllium
Definition
a bulk-forming laxative, is used to treat constipation
Term
scopolamine
Definition
Used in transdermal patches to reduce motion sickness and post-operative nausea. Not useful for chemotherapy-induced nausea
Term
dronabinol
Definition
Cannabinoid. used for prophylaxis of chemotherapy-induced emesis. Stimulates appetite as well.
Term
benzodiazepines
Definition
Can reduce the anticipatory component of nausea and vomiting, but are not really anti-emetics.
Term
cholestyramine
Definition
anion-exchange resin that binds bile acids and some bacterial toxins. Used to treat bile salt-induced diarhea after ileal resection,
Term
bismuth subsalicylate
Definition
A mineral. Has a mild antibiotic activity and appears to have anti-inflammatory effects. Can be used for diarrhea and mechanism is unclear.
Term
infliximab
Definition
An immunoglobin which binds to and neutralizes TNF alpha. Approved to for use in moderate to severe crohn's disease (promotes healing)
Term
laxatives
Definition
thought to act via physical means (osmotic, wetting agents) but can also stimulate secretion and contraction to help with constipation
Term
Enemas
Definition
Introduces a solution into the lower bowel with the goal of evacuating its contents. Treat moderate to severe constipation
Term
Albuterol
Definition
Short acting B2 selective adrenergic agonist. Bronchodilation
Term
Salmeterol
Definition
Long acting B2 selective adrenergic agonist. Bronchodilation
Term
Theophyline
Definition
Methylxanthine related to caffeine. Inhibits PDE, which helps with relxation of bronchi and inhibits mast cell degranulation (due to increased cAMP). anti-inflammatory effects due to Adenosine receptor antagonist. Reduce inflammation in COPD
Term
Ipratropium bromide
Definition
Blocks Muscarinic receptors in bronchial smooth muscles. Alternative to B2 agonists . Slower onset of action.
Term
Cromolyn sodium
Definition
Inhibits antigen-induced drganulation of mast cells. Suppresses many inflammatory cells. Inhibits irritant nerves. Prophylactic; most effective in allergen-induced asthma.
Term
Prednisone
Definition
Oral Glucocorticoid. Antiinflammatory and inhibits production of inflammatory cytokines. First-line treatment in moderate to severe asthma
Term
Beclomethasone
Definition
Inhaled Glucocorticoid. Antiinflammatory and inhibits production of inflammatory cytokines. First-line treatment in moderate to severe asthma
Term
Fluticasone
Definition
Inhaled Glucocorticoid. Antiinflammatory and inhibits production of inflammatory cytokines. First-line treatment in moderate to severe asthma
Term
Zafirlukast
Definition
LTD4-receptor antagonist. Effective against antigen-induced asthma, EIA, and mild asthma, but not strongly anti-inflammatory.
Term
Zileuton
Definition
5-lipoxygenase inhibitor
Blocks production of leukotrienes
Term
Omalizumab
Definition
Recombinant monoclonal antibody aginst IgE. Effective in moderate asthma, but expensive
Term
N-acetylcysteine
Definition
Splits disulfide bonds of mucopolysaccharides. Efficacy in COPD has been questions. Also used to treat acetaminophen overdose.
Term
Ambroxol
Definition
Antixidant mucolytic agent, also has anti-inflammatory activity.
Term
alpha1-antitrypsin
Definition
Glycoprotein produced in in liver, secreted in blood, diffuses into lung. Inhibits neutrophil elastase (protease inhibitor). Prevents destruction of connective tissue in alveolar walls due to excess neutrophil protease (theory)
Term
Oxygen
Definition
Used when chronic severe hypoxemia develops.
Term
rhDNase
Definition
Can result in decreased dyspnea and improved sense of well being. Recombinant human deoxyribonuclease.
Term
Codeine
Definition
Supresses cough center in the medula
Term
Dextromethorphan
Definition
D-isomer of the codeine analog levorphanol. equieffective to codeine, but non-addivtive tho still subject to abuse.
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