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Inflammation, Healing, and Repair
PA school pathology
52
Pathology
Graduate
11/05/2009

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Cards

Term
cellulitis
Definition
Term
chemokine
Definition
one of the chemoattractants; include IL8, MCP-1, and C3a
Term
abscess
Definition
a compartmentalized collection of purulent inflammation (pus) and necrotic tissue deep within tissue or a body cavity; most often the result of a pyogenic bacterial infection; healing with granulation tissue and/or fibrosis occurs at the outer margin encircling the zone of necrosis and inflammation
Term
chemotaxis
Definition
Term
cytokine
Definition
Term
edema, inflammatory
Definition
the accumulation of protein-rich fluid in the tissues as a result of increased vascular permeability
Term
effusion
Definition
Term
emigration
Definition
neutrophils and monocytes are induced by chemoattractants from the site of injury to move out of the vessel through the endothelial gaps; happens within minutes and is maximal at 6-24 hours after injury onset
Term
empyema
Definition
Term
erosion
Definition
Term
exudate
Definition
a protein-rich fluid that includes many of the mediators, immunoglobulins, and key ingredients required for the healing of the injury
Term
exudate, serous
Definition
watery, relatively poor in cells and protein; commonly seen in early bacterial infectiosn
Term
exudate, suppurative
Definition
pus; a thick fluid composed of leukocytes, perdominantly neutrophils, and liquefied tissue, commonly seen with pyogenic infections like staphylococci
Term
exudate, fibrinous
Definition
moderate-extensive protein content, with fibrin formation; commonly seen in serous sacs such as pleural and pericardial space
Term
exudate, serosanguinous
Definition
any exudate that contains blood, commonly seen in fulminating suppurative inflammation
Term
fibrosis
Definition
Term
fibonectin
Definition
a high molecular-weight glycoprotein derived from plasma, later produced by proliferating endothelial cells and fibroblasts; binds collagens, proteoglycans, and other macromolecules to cell surfaces to form a matrix; also a potent chemoattractant for fibroblasts
Term
granulation tissue
Definition
formed at the second stage of repair, includes three predominate cell types: macrophages, endothelial cells, myofibroblasts
Term
granuloma
Definition
nodular aggregates of macrophages with variable numbers of associated lymphocytes; nodules are usually about 1 mm, but can coalesce to form substantial masses
Term
inflammation
Definition
Term
innate immunity
Definition
Term
integrin
Definition
firmly binding ligands expressed on the surfaces of leukocytes and endothelial cells; the mechanism by which neutrophils and monocytes stop rolling and become fixed to the endothelium; include VCAM, ICAM, PECAM, LFA, and Mac-1
Term
margination
Definition
Term
phagocytosis
Definition
cellular ingestion of microorganisms, cell debris, and particulate foreign matter; involves several steps, the first 3 are fueled by anaerobic glycolysis
Term
phagolysosome
Definition
Term
resolution
Definition
Term
selectin
Definition
loosely binding ligands expressed on surfaces of leukocytes and endothelial cells which make them "sticky"; includes endothelial-E selectin and platelet-P and leukocyte-L selectins
Term
transudate
Definition
Term
ulcer
Definition
Term
platelets
Definition
Term
lymphocytes
Definition
Term
giant cells
Definition
Term
mast cells/basophils
Definition
Term
plasma cells
Definition
Term
neutrophils
Definition
Term
eosinophils
Definition
Term
fibroblasts
Definition
Term
adhesion molecules
Definition
Term
endothelial cells
Definition
Term
monocytes
Definition
Term
macrophages
Definition
Term
histiocytes
Definition
Term
vasoactive amines
Definition
Term
nitric oxide
Definition
Term
proteases
Definition
Term
lysosomal granule contents
Definition
Term
arachidonic acid metabolites
Definition
Term
oxygen-derived free radicals
Definition
Term
platelet activating factor
Definition
a cell-derived mediator of acute inflammation; causes vasodilation and increased permeability; platelet activation with multiple effects
Term
neuropeptides
Definition
Term
platelet activating factor
Definition
Term
oxygen-derived free radicals
Definition
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