Shared Flashcard Set

Details

Immunosuppressants
FA pg 215-217
44
Medical
Graduate
02/27/2011

Additional Medical Flashcards

 


 

Cards

Term
site of diverticula
Definition
sigmoid colon
Term
opening snap
Definition
mitral stenosis , diastolic murmur, head in l lateral decubitous position.
Term

Cyclosporine

Mechanism

Definition

Binds to cyclophilins

complex inhibits calcineurin, prevent production of IL-2 and it's receptor

--> block in differentiation and activation of T-cells

Term

Cylcosporine

Clinical Use

Definition

post transplantation suppression of organ rejection

 

AND

 

selected autoimmune disorders

Term

Cyclosporine

Toxicity

Definition

1) viral infections

2) lymphoma

3) nephrotoxic (preventable with mannitol diuresis)

Term

Tacrolimus (FK506)

mechanism

Definition

binds to FK-binding protein

inhibits secretion of IL-2 and other cytokines

similar to cyclosporine

Term

Tacrolimus (FK506)

clinical use

Definition

potent immunosuppresive for

organ transplant recipients

Term

Tacrolimus (FK506)

toxicity

Definition

Siginificant!

1) nephrotoxicity

2) peripheral neuropathy

3) HTN

4) pleural effusion

5) hyperglycemia

Term

Sirolimus (rapamycin)

mechanism

Definition

binds to mTOR

inhibits T-cell proliferation in response to IL-2

Term

Sirolimus (rapamycin)

clinical use

Definition

Post-kidney transplant immunosuppression

 

used in combo with cyclosporine and corticosteroids

Term

Sirolimus (rapamycin)

Toxicity

Definition

1) Hyperlipidemia

2) thrombocytopenia

3) leukopenia

Term

Daclizumab

mechanism

Definition
monocolonal antibody with high affinity for the IL-2 receptor on activated T-cells
Term

Azathioprine

Mechanism

Definition

Antimetabolite precursor of 6-mercaptopurine

interferes with metabolism and synthesis of nucleic acids

toxic to proliferating lymphocytes

Term

Azathioprine

Clinical Use

Definition

1) kidney transplantation

2) autoimmune disorders (ie- glomerulonephritis and hemolytic anemia)

Term

Azathioprine

Toxicity

Definition

1) bone marrow suppression

2) active metabolite mecaptopurine is metabolized by xanthine oxidase; thus, toxic effects may be increased by allopurinol

Term

muromonab-CD3 (OKT3)

Mechanism

Definition

monoclonal antibody

binds to CD3 (epsilon chain) on the surface of T-cells

 

Blocks cellular interaction with CD3 protein responsible for T-cell signal transduction

Term

muromonab-CD3 (OKT3)

Clinical use

Definition
1) immunosuppression post-kidney transplant
Term

Muromonab-CD3 (OKT3)

Toxicity

Definition

1) cytokine release syndrome

2) hypersensitivity reaction

Term

Aldesleukin (interleukin 2)

clinical use

Definition

1) renal cell carcinoma

2) metastatic melanoma

Term

Erythropoietin (epoetin)

clinical use

Definition
anemias (especially in renal failure)
Term

Filgrastim (granulocyte colony-stimulating factor)

clinical use

Definition
recovery of bone marrow
Term

Sargramostim (granulocyte-macrophage colony-stimulating factor)

clinical use

Definition
recovery of bone marrow
Term

Alpha-interferon

clinical use

Definition

1) hepatitis B and C

2) Kaposi's sarcoma

3) leukemias

4) malignant melanoma

Term

Beta-interferon

Clinical use

Definition
1) multiple sclerosis
Term

gamma-interferon

clinical use

Definition
1) chronic granulomatous disease
Term

oprelvekin (interleukin-11)

clinical use

Definition
1) thrombocytopenia
Term

Thrombopoietin

clinical use

Definition
1) Thrombocytopenia
Term

Muromonab-CD3 (OKT3)

Target

Definition
CD3
Term

Muromonab-CD3 (OKT3)

Clinical use

Definition
prevent acute transplant rejection
Term

Daclizumab

target

Definition
IL-2 receptor
Term

Daclizumab

clinical use

Definition
prevent acute rejection of renal transplant
Term

Digoxin Immune Fab

Target

Definition
digoxin
Term

Digoxin Immune Fab

clinical use

Definition
antidote for digoxin intoxication
Term

Infliximab

target

Definition
TNF-alpha
Term

Infliximab

clinical use

Definition

1) chron's disease

2) rheumatoid arthritis

3) psoriatic arthritis

4) ankylosing spondylitis

Term

Adalimumab

target

Definition
TNF-alpha
Term

Adalimumab

clinical use

Definition

1) chron's disease

2) rheumatoid arthritis

3) psoriatic arthritis

Term

Abciximab

target

Definition
glycoprotein IIb/IIIa
Term

Abciximab

Clinical use

Definition
prevent cardiac ischemia in unstable angina and in patients treated with percutaneous coronary intervention
Term

Trastuzumab (herceptin)

target

Definition
erb-B2
Term

Trastuzumab (herceptin)

clinical use

Definition
HER-2-overespressing breast cancer
Term

Rituximab

target

Definition
CD-20
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