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Immunology
Physiology Exam #2 Immunology
63
Physiology
Undergraduate 2
03/16/2014

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Term
What is the goal of the immune system?
Definition
to defend against diseases in the blood system
Term
What cells are involved in the immune system?
Definition
Neutrophils Lymphocyts eosinphils monocytes besophils
NLMEB
Term
What is NLMEB?
Definition
Neutrophils Lymphocytes Monocytes Eosinophils Besophils
Term
What is "BTN Lymph"?
Definition
B cells T cells natural killer cells
Term
What cells have memory?
Definition
T Cells
Term
What are the central and peripheral lymphoid tissues?
Definition
Term
What is Humoral immunity?
Definition
Term
Who are the major players in Humoral Immunity?
Definition
B cells
Term
What is Cell-mediated immunity?
Definition
Term
Who are the major players in cell-mediaed immunity?
Definition
T cells
Term
What is innate immunity?
Definition
Term
Who are the major players in innate immunity?
Definition
NLMEB
Term
What is adaptive immunity?
Definition
Aka "the military"
Term
Who are the major players in adaptive immunity?
Definition
Term
Who are the local police?
Definition
Innate Immunity
Term
How long till the local police take action? How strong are they?
Definition
Immediate/Not very Strong
Term
What is the complement system/cascade?
Definition
Term
What is the MAC attack?
Definition
Membrace attack complex- pokes really big holes in the cell membrane (lysis) simmalir to perfornin which is like cytotoxic cells CD-8
Term
What are antibodies?
Definition
an immunoglobulin molecule that reacts with a specific antigen that induced its synthesis and with similar molecules
Term
What is the goal of the innate immune system? (Neutralize and opsonize)
Definition
Term
What are PAMPs?
Definition
Pathogen- Associated Molecular Patterns
Term
What are PRRs?
Definition
Pattern Recognition Receptors
Term
Who are the military?
Definition
T cells (adaptive immunity)
Term
How long does it take for the military to take action? How strong are they?
Definition
3-4 days
Term
How does it accomplish this?
What is the first line of defense?
What is the second line of defense?
What is the third line of defense?
Definition
1st Line of defense : Skin / Mucus / Acid PH
2nd Line of Defense: NLMEB
3rd Line of Defense: Cells and Proteins
Term
What are the 3 antigen presenting cells (APCs)?
Definition
DMB
Dendretic-Macrophage-BCEll
Term
Where are each of the antigen presenting cells found?
Select from: peripheral blood (circulation), lymphoid tissue, connective tissue, epithelia, and body cavities.
Definition
Term
How do they get antigen (Ag) for presentation? (hint: big eaters)
Definition
Term
What cell(s) do the APC present antigens (Ag) to?
Definition
T cells
Term
What is the process of APC activation and maturation?
Definition
§ Dendritic cells
§ B cells
§ Macrophages
Term
What does MHC stand for?
Definition
Major Histocompatibility Complex
Term
What is MHC?
Definition
group of genes that code for proteins found on the surfaces of cells that help the immune system recognize foreign substances
Term
What is MHC-I?
Definition
a marker that all cells have. also known as CD-8
Term
Where in the cell are the foreign substances coming from? (MHC-I)
Definition
Term
What type of T-cell does it bind to?
Definition
Term
What is MHC-II?
Definition
CD-4 (also known as T Helper cells) only DMB has this marker
Term
Where in the cell are the foreign substances coming from? (MHC-II)
Definition
Term
What type of T-cell does it bind to?
Definition
TH1 and TH2
Term
Which cells in the body do/do not possess MHC-I? MHC-II?
Definition
Term
What are T-lymphocytes (T-cells)?
Definition
Term
Where are T-cells made?
Definition
Bone Marrow
Term
Where do T-cells mature?
Definition
Thymus
Term
What do T-cells do?
Definition
Term
Do T-cells have memory?
Definition
yes
Term
What are the T cell functions?
TH1
Definition
Eats the problem
Term
What is their action?
TH2
Definition
Tags the problem
Term
What are two (2) roles of TH1? TH2? What’s the timescale for such killing action to be initiated: minutes, hours, days, or weeks?
Definition
Term
Do TH1 or TH2 cells activate macrophages? Which of the two inhibit macrophage activation?
Tc
Definition
Term
What are the three (3) mechanisms by which CTLs kill?
Definition
Term
Do CTL's kill non-specifically or directional?
Definition
Directional
Term
What’s the timescale for CTL killing action to be initiated: minutes, hours, days, or weeks?
Definition
Term
What are perforins and what do they do?
(CD4 or CD8)
Definition
CD-8 They cause lysois (cell death)
Term
Which T cells are CD4? CD8?
Definition
CD-8 is T6
CD-4 is T helper Cells
Term
Which MHC complex does CD 4 interact with? CD8?
Definition
MHC 1 is with Cd-8
MHC 2 is with CD-4
Term
What do NK cells do?
Definition
do not attack invading organisms directly but instead destroy the body’s own cells that have either become cancerous or been infected with a virus
Term
What are B-lymphocytes (B-cells)?
Definition
Term
Where are B cells made?
Definition
bone marrow
Term
Where do B cells mature?
Definition
Thymus
Term
What do B cells do?
Definition
Secrete antibodies
Term
Do B cells have memory?
Definition
yes
Term
Who are B cells dependent on for activation?
Definition
T cells
Term
What do B cells become when they secrete antibodies?
Definition
plasma cells
Term
What are the four signs of inflammation?
Definition
Heat
Redness
Pain
Swelling
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