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Immunology
Cytokines, cell markers, HLA typing, autoantibodies
72
Medical
Graduate
04/09/2013

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Cards

Term
IL-1
Definition
Pyrogen (fever, acute inflammation)
Activates endothelium to express adhesion molecules
Induces chemokine secretion to recruit leukocytes
Term
IL-2
Definition
Stimulates growth of helper, cytotoxic and regulatory T cells
Term
IL-3
Definition
Stimulates bone marrow to grow and differentiate.
Functions like GM-CSF
Term
IL-4
Definition
Induces differentiation into Th2 cells
Promotes growth of B cells
Enhances class switching to IgE and IgG
Term
IL-5
Definition
Promotes differentiation of B cells
Enhances class switching to IgA
Stimulates growth and differentiation of eosinophils
Term
IL-6
Definition
Pyrogen (fever and induction of acute-phase proteins)
Secreted by Th2 cells
Term
IL-8
Definition
Chemotactic factor for PMNs
Term
IL-12
Definition
Induces differentiation of T cells into Th1 cells
Activates NK cells
Secreted by B cells
Term
TNF-alpha
Definition
Mediates septic shock
Activates endothelium
Causes leukocyte recruitment, vascular leak
Term
Interferon gamma
Definition
Activates macrophages and Th1 cells
Suppresses Th2 cells
Antiviral and antitumor properties
Increases MHC I and II expression and antigen presentation in all cells
Activates NK cells to kill virus infected cells
Term
IL-10
Definition
Modulates inflammatory response
Inhibits actions of activated T cells and Th1
Secreted by regulatory T cells
Term
TGF-beta
Definition
Modulates inflammatory respose
Term
Interferon alpha and beta
Definition
Inhibit viral protein synthesis by inducing production of ribonuclease that degrades viral mRNA
Term
Helper T cells
Definition
Common: TCR, CD3, CD28 (binds B7 on APC)
Unique: CD4, CD40 ligand
Term
Cytotoxic T cells
Definition
Common: TCR, CD3, CD28
Unique: CD8
Term
B cells
Definition
Ig (binds antigen)
CD19, CD20, CD21 (EBV receptor), CD40, MHC II
Term
Macrophages/monocytes
Definition
CD14, CD40, MHC II, B7, Fc ad C3b receptors
Term
NK cells
Definition
CD16, CD56
Term
Neutrophil chemotaxis
Definition
IL-8
n-formylated peptides
leukotriene B4
%-HETE
C5a of complement
Term
Regulatory T cells
Definition
CD3, CD4, CD25 (IL-2 receptor)
Term
HLA A3
Definition
Hemochromatosis
Term
HLA B27
Definition
Psoriasis, Ankylosing Spondylitis, Inflammatory bowel disease, Reiter's syndrome (reactive arthritis)
Term
HLA DQ2/DQ8
Definition
Celiac
Term
HLA DR2
Definition
Multiple sclerosis, hay fever, SLE, Goodpasture's
Term
HLA DR3
Definition
Diabetes mellitus type I
Term
HLA DR4
Definition
Rheumatoid arthritis, diabetes mellitus type I
Term
HLA DR5
Definition
Pernicious anemia --> B12 deficiency, Hashimoto's thyroiditis
Term
Antinuclear antibodies (ANA)
Definition
SLE, nonspecific
Term
Anti-dsDNA, anti-Smith
Definition
SLE
Term
Antihistone
Definition
Drug induced lupus
Term
Rheumatoid factor, anti-CCP
Definition
Rheumatoid arthritis
Term
Anticentromere
Definition
Scleroderma (CREST syndrome)
Term
Anti-Scl-70 (anti-DNA topoisomerase I)
Definition
Scleroderma (diffuse)
Term
Antimitochrondrial
Definition
Primary biliary cirrhosis
Term
IgA antiendomysial, IgA anti-tissue transglutaminase
Definition
Celiac
Term
Anti-basement membrane
Definition
Goodpasture's syndrome
Term
Anti-desmoglein
Definition
Pemphigis vulgaris
Term
Antimicrosomal, antithyroglobulin
Definition
Hashimoto's thyroiditis
Term
Anti-Jo-1, anti-SRP, anti-Mi-2
Definition
Polymyositis, dermatomyositis
Term
Anti-SSA (anti-Ro)
Definition
Sjogren's syndrome
Term
Anti-SSB (anto-La)
Definition
Sjogren's syndrome
Term
Anti-U1 RNP (ribonucleoprotein)
Definition
Mixed connective tissue disease
Term
Anti-smooth muscle
Definition
Autoimmune hepatitis
Term
Anti-glutamate decarboxylase
Definition
Type I diabetes mellitus
Term
c-ANCA (PR3-ANCA)
Definition
Granulomatosis and polyangiitis (Wegener's)
Term
p-ANCA (MPO-ANCA)
Definition
Microscopic polyangiitis, Churg-Strauss syndrome
Term
Anaphylaxis (type of hypersensitivity)
Definition
Type I
Term
Rhinitis (type of hypersensitivity)
Definition
Type 1
Term
Hay fever (type of hypersensitivity)
Definition
Type 1
Term
Eczema (type of hypersensitivity)
Definition
Type 1
Term
Hives (type of hypersensitivity)
Definition
Type 1
Term
Asthma (type of hypersensitivity)
Definition
Type 1
Term
Autoimmune hemolytic anemia (type of hypersensitivity)
Definition
Type 2
Term
Pernicious anemia (type of hypersensitivity)
Definition
Type 2
Term
Idiopathic thrombocytopenic purpura (type of hypersensitivity)
Definition
Type 2
Term
Erythroblastosis fetalis (type of hypersensitivity)
Definition
Type 2
Term
Acute hemolytic transfusion reaction (type of hypersensitivity)
Definition
Type 2
Term
Rheumatic fever (type of hypersensitivity)
Definition
Type 2
Term
Goodpasture's syndrome (type of hypersensitivity)
Definition
Type 2
Term
Bullous pemphigoid (type of hypersensitivity)
Definition
Type 2
Term
Pemphigus vulgaris (type of hypersensitivity)
Definition
Type 2
Term
SLE (type of hypersensitivity)
Definition
Type 3
Term
Polyarteritis nodosa (type of hypersensitivity)
Definition
Type 3
Term
Poststreptococcal glomerulonephritis (type of hypersensitivity)
Definition
Type 3
Term
Serum sickness (type of hypersensitivity)
Definition
Type 3
Term
Arthus reaction following tetanus vaccine (type of hypersensitivity)
Definition
Type 3
Term
Multiple sclerosis (type of hypersensitivity)
Definition
Type 4
Term
Guillain Barre (type of hypersensitivity)
Definition
Type 4
Term
Graft versus host disease (type of hypersensitivity)
Definition
Type 4
Term
PPD (type of hypersensitivity)
Definition
Type 4
Term
Contact dermatitis (type of hypersensitivity)
Definition
Type 4
Term
Febrile non-hemolytic transfusion reaction (type of hypersensitivity)
Definition
Type 2
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