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immuno
vocab quiz 2
30
Accounting
Pre-School
02/09/2011

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Term
immunoglobulin
Definition
antigen-recognition molecules of B cells
Term
variable region
Definition
antigen-binding region
Term
major histocompatibility complex
Definition
large cluster of genes. has a cleft running across their outermost surface in which a variety of peptides can be bound
Term
IgG
Definition
most abundant immunoglobulin and has several subclasses
Term
IgD
Definition
characterized by gamma heavy chains. appears as surface immunoglobulin on mature naive B cells but its function is unknown
Term
IgA
Definition
class of immunoglobulin characterized by alpha heavy chains. main antibody class secreted by mucosal lymphoid tissues
Term
IgE
Definition
class of immunoglobulin characterized by E heavy chains; involved in the defense against parasite infections and in allergic reactions
Term
Heavy chain
Definition
50kDa (linked together by disulfide bonds)
Term
Light chain
Definition
25kDa (linked to a heavy chain by a disulfide bond)
Term
Lambda
Definition
type of light chain
Term
Kappa
Definition
type of light chain
Term
Fab fragment
Definition
two identical fragments that contain the antigen binding activity. they correspond to the two identical arms of the antibody molecule
Term
Fc fragment
Definition
fragment containing no antigen-binding activity but was originally observed to crystallize readily (fragment crystallizable= fc) the part of the antibody molecule that interacts with effector molecules and the cells
Term
Hinge region
Definition
a flexible domain that joins the Fab arms to the Fc piece
Term
Hypervariable region
Definition
three particularly variable segments that can be identified in both the VH and VL domains; denoted HV1, HV2, HV3
Term
Framework region
Definition
the regions between the hypervarial region that shows less variability
Term
Antigen binding site
Definition
found at the surface of the antibody molecule that makes up physical contact with the antigen; they are made up of 6 hypervariable loops
Term
Epitope
Definition
structure recognized by an antibody
Term
TCR a
Definition
polypeptide chain linked to TCRB by a disulfide bond
Term
TCR b
Definition
polypeptide chain linked to TCRA by a disulfide bond
Term
alpha: beta TCR
Definition
contain two chains: TCR A and TCR b
Term
gamma: S TCR
Definition
Term
MHC class I
Definition
consist of 2 polypeptide chains: alpha chain; bind short peptides of 8-10 amino acids by both ends
Term
MHC class II
Definition
consists of a noncovalent complex of two chains, alpha and beta, which span the membrane; the length of MHC class II are not restrained
Term
Peptide-binding groove
Definition
folded alpha1 and alpha2 domains that form walls of a cleft where the peptide binds
Term
beta2 microglobulin
Definition
not polymorphic and is encoded on a different chromosome (chromosome 15)
Term
CD4 co-receptor
Definition
is carried by T cells whose function it is to activate other cells
Term
CD8 co-receptor
Definition
is carried by cytotoxic T cells
Term
constant region
Definition
region of the antibody molecule that engages the effector functions of the immune system (comes in 5 forms)
Term
IgM
Definition
characterized by micro heavy chains. first immunoglobulin to appear on the surface of B cells and the first to be secreted
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