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Immuno Clues
Immune Clues
113
Medical
Post-Graduate
12/09/2011

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Term
WHAT CYTOKINES DO MACROPHAGES STIM?
Definition
IL - 1
Term
WHAT CYTOKINES DO T HELPER CELLS STIM?
Definition
ALL OF EM EXPECT IL-1 (THOSE ARE DONE BY MACROPHAGES)
Term
WHICH ENLARGED LYMPH NODES ARE MOST LIKELY MALIGNANT?
Definition
SUPRACLAVICULAR, EPITROCHLEAR (ABOVE ELBOW), AND INGUINAL
Term
WHAT IS CD8?
Definition
T KILLER OR T SUPPRESSOR CELL; RESPONDS TO mhc1 (SELF)
Term
WHICH OF YOUR CELLS EXPRESS MHC 1?
Definition
ALL EXPECT RBC'S N' PLATELETS - B/C THEY DON'T HAVE nucleus!
Term
WHAT IS CD4?
Definition
T HELPER CELLS; RESPONDS TO MHC2 (NON-SELF)
Term
WHAT TYPE OF IMMUNITY DOES TH1 PROVIDE?
Definition
CELL MEDIATED
Term
WHAT TYPE OF IMMUNITY DOES TH2 PROVIDE?
Definition
ANTIBODY/HUMORAL
Term
WHAT DO B CELL DEF PATIENTS DIE FROM?
Definition
BACTERIAL INFECTION
Term
WHAT IS COMMON VARIABLE HYPOGAMMAGLOBULINEMIA?
Definition
KIDS WITH B CELLS THAT DON'T DIFFERNTIATE INTO PLASMA CELLS -- LEADS TO LOW AB
Term
WHAT IS BRUTON'S AGAMMAGLOBULINEMIA?
Definition
YOUNG ADULTS WITH DEFECTIVE TYROSINE KINASE -- LEADS TO NO AB, XLINKED
Term
WHAT IS JOB BUCKLEY SYNDROME?
Definition
REDHEADED FEMALES, STUCK WITH IGE STAGE
Term
WHAT IS MULTIPLE MYELOMA?
Definition
MULTIPLE OSTEOLYTIC LESION, IGG, KAPPA LIGHT CHAINS, ROULEUX
Term
WHAT IS HEAVY CHAIN DISEASE?
Definition
IGA AND MULTIPLE MYELOMA OF THE GI TRACT
Term
WHAT IS SELECTIVE IGG2 DEF?
Definition
RECURRENT ENCAPSULATED INFECTIONS
Term
WHAT IS SELECTIVE IGA DEF?
Definition
TRANSFUSION ANAPHYLAXIS, MUCOUS MEMBRANE INFECTIONS
Term
WHAT IS HAIRY CELL LEUKEMIA?
Definition
FRIED EGG/SUNBURST APPEARANCE, TRAP+
Term
WHAT IS ATAXIA TELANGIECTASIA?
Definition
LOW IGA, NEURO PROBLEMS, ATM GENE
Term
WHAT IS HYPER IGM SYNDROME?
Definition
HIGH IGM, LOW ALL OTHER AB
Term
WHAT DO T CELL DEF PATIENTS DIE OF?
Definition
VIRAL INFECTIONS
Term
WHAT IS DIGEORGE SYNDROME?
Definition
NO THYMUS/INFERIOR PARATHYROID, LOW CA2+
Term
WHAT IS CHRONIC MUCOCUTANEOUS CANDIDASIS?
Definition
T CELL DEFECT AGAINST CANDIDA ALBICANS, CHRONIC FATIGUE
Term
WHAT IS SCID?
Definition
NO THYMUS, FRAYED LONG BONES, BABY DIES BY 18MO
Term
WHAT IS WISCOTT-ALDRICH?
Definition
LOW IGM, LOW PLATELETS, HIGH IGA, ECZEMA, PETECHIAE
Term
WHAT DOES CD4 COUNT TELL YOU?
Definition
STATUS OF HIV (NORMAL 1000)
Term
WHAT DOES VIRAL LOAD TELL YOU?
Definition
PROGRESSION OF HIV
Term
WHAT ORGANS HAVE THE MOST CD4 RECEPTORS?
Definition
BLOOD VESSELS, BRAIN, TESTICLES, CERVIX, RECTUM -- ALL THE AREAS HIV AFFECTS THE MOST!!
Term
WHAT ARE THE 3 TEST USED TO SCREEN FOR HIV?
Definition
1/ELISA; DETECTS, IGG AB TO P24 AG, 2/WESTERN BLOT; SEE>2 PROTEINS, 3/PCR; DETECTS VIRUS (USE IN BABIES)
Term
WHAT IS THE DEFINITION OF AIDS?
Definition
CD4 <200/uL OR CLINICAL SYMPTOMS
Term
WHAT ARE THE LIVE VACCINES?
Definition
"Bring Your Own Very Small Virus + MMR"
BCG, YELLOW FEVER, OPV POLIO (DISCONTINUED), VARICELLA, SMALLPOX, rotaVIRUS, MEASLES(RUBEOLA) /MUMPS /RUBELLA (GERMAN 3 DAY MEASLES)
Term
WHAT IS PRIMARY BILIARY CIRRHOSIS?
Definition
ANTI-MITOCHONDRIAL AB, PRURITIS, FEMALES
Term
WHAT IS PRIMARY SCLEROSING CHOLANGITIS?
Definition
P-ANCA AB, BILE DUCT INFLAMMATION, ONION SKINNING, IBD
Term
WHAT IS TYPE 1 AUTOIMMUNE HEPATITIS?
Definition
ANTI-SM AB, YOUNG WOMEN
Term
WHAT IS TYPE 2 AUTOIMMUNE HEPATITIS?
Definition
ANTI-LKM AB, KIDS
Term
WHAT IS BULLOUS PEMPHIGOID?
Definition
ANTI-HEMIDESMOSOMES AB, SKIN BULLAE, STAYS LOCALLY
Term
WHAT IS CELIAC SPRUE?
Definition
ANTI-GLIADEN AB, EATING WHEAT -- STEATORRHEA
Term
WHAT IS CREST SYNDROME?
Definition
ANTI-CENTROMERE AB
Term
WHAT IS DERMATITIS HERPETIFORMIS?
Definition
ANTI-BMZ AB, ANTI-ENDOMYSIAL AB, VESICLES ON ANTERIOR THIGH, (EXTENSORS - PSORIASIS)
Term
WHAT IS DERMATOMYOSITIS?
Definition
ANTI-JO-1 AB, MYOSITIS + RASH (MC ON AROUND EYEs)
Term
WHAT IS DM TYPE 1?
Definition
ANTI-ISLET CELL, ANTI-GAD AB, POLYURIA, POLYDIPSIA, WEIGHT LOSS, ALSO CAUSED BY COXSACKIE A
Term
WHAT IS DRUG INDUCED LUPUS?
Definition
ANTI-HISTONE AB, "HIPPPE" DRUGS CAUSE IT.
HYDRALAZINE, INH, PROCAINAMIDE, PENICILLAMINE, PHENYTOIN, ETHOSUXIMIDE
Term
WHAT IS GASTRITIS TYPE A?
Definition
ANTI-PARIETAL CELL AB, ATROPHIC GASTRITIS, ADENOca, AUTOIMMMUNE
Term
WHAT IS GOODPASTURE'S?
Definition
ANTI-GBM AB, ATTACKS LUNGS N' KIDNEY, RPGN - DOES NOT EFFECT SINUS (WEGNERS'S)
Term
WHAT IS GRAVE'S DISEASE?
Definition
ANTI-TSHr AB, HYPERTHYROID, BUG EYES, PRETIBIAL MYXEDEMA
Term
WHAT IS GUILLAIN-BARRE?
Definition
ANTI-GANGLIOSIDE AB, ASCENDING PARALYSIS, 2 WK AFTER URI - OR - CAMPYLOBACTER JEJUNI
Term
WHAT IS HASHIMOTO'S?
Definition
ANTI-MICROSOMAL AB AGAINST (THYROID PEROXIDASE (TPO), HYPOTHYROID
Term
WHAT IS ITP?
Definition
ANTI-PLATELET AB, ANTI-GP2B3A AB, THROMBOCYTOPENIA
Term
WHAT IS MIXED CT DISEASE?
Definition
ANTI-RNP AB
Term
WHAT IS MONONUCLEOSIS?
Definition
HETEROPHILE AB, TEENAGER W/SORE THROAT
Term
WHAT IS MPGN TYPE 2?
Definition
ANTI C3 CONVERTASE AB = C3 NEPHRITIC FACTOR
Term
WHAT IS MULTIPLE SCLEROSIS?
Definition
ANTI-MYELIN AB, MIDDLE AGED FEMALE W/VISION PROBLEMS, INFLAMMATORY COURSE, SO VISION PROBLEMS COME AND GO
Term
WHAT IS MYASTHENIA GRAVIS?
Definition
ANTI-ACETYLCHOLINE RECEPTOR AB, FEMALE W/PTOSIS, WEAKER AS DAY GOES ON (DRUNK LOOK BY 7PM)
Term
WHAT IS PARAOXYSMAL HEMOLYSIS?
Definition
DONATH LANDSTEINER AB, BLEEDS WHEN COLD
Term
WHAT IS PEMHIGUS VULGARIS?
Definition
ANTI-DESMOSOMES AB, SKIN SLOUGHS OFF WHEN TOUCHED
Term
WHAT IS PERNICIOUS ANEMIA?
Definition
ANTI-IF AB, VIT B12 DEF --> MEGALOBLASTIC ANEMIA
Term
WHAT IS POLYARTERITIS NODOSA?
Definition
P-ANCA AB, ATTACKS GUT N' KIDNEY, HEP B - no lung involvement! (least likely? to involve lung!!)
Term
WHAT IS POST-STREP GN?
Definition
ASO AB, NEPTHRITIC W/COMPLEMENT DEPOSITION
Term
WHAT IS RHEUMATOID ARTHRITIS?
Definition
RHEUMATOID FACTOR, PAIN WORSE IN THE MORNING
Term
WHAT IS SCLERODERMA?
Definition
ANTI-SCL70 - ANTI-TOPOISOMERASE, FIBROSIS OF ORGANS, TIGHT SKIN
Term
WHAT IS SJOGRENS?
Definition
ANTI-SSA AB, DRY "SAND IN" EYES, DRY MOUTH, ARTHRITIS
Term
WHAT IS SLE?
Definition
ANTI-DS DNA / SM / CARDIOLIPIN (KIDNEY N' HEART N' ABORTIONS), RASH, PHOTO-SENSITIVITY, ORAL ULCERS, RF
Term
WHAT IS SLE CEREBRITIS?
Definition
ANTI-NEURONAL AB, ANTI-RIBOSOMAL AB
Term
WHAT IS VITILIGO?
Definition
ANTI-MELANOCYTE AB, WHITE PATCHES
Term
WHAT IS WARM HEMOLYSIS?
Definition
ANTI-RH AB, BLEEDS AT BODY TEMP
Term
WHAT IS WEGENERS?
Definition
C-ANCA AB, ATTACKS ENT, LUNGS, N' KIDNEY
Term
WHAT IS Henoch–Schönlein purpura (HSP)?
Definition
IGA DISEASE 2 WEEKS AFTER COMMON COLD - BERGER'S
Term
WHAT IS BERGER'S?
Definition
IGA DISEASE 2 WEEKS AFTER VACCINATION - SERUM SICKNESS
Term
WHAT IS ALPORTS?
Definition
IGA DISEASE 2 WEEKS AFTER DIARRHEA - HSP, POLIO
Term
MC LEUKEMIA IN KIDS
Definition
ALL
Term
MIDDLE AGED WOMEN IN HER 40'S, MC LEUKEMIA?
Definition
CML
Term
OLDER 60 YO LEUKEMIA?
Definition
CLL
Term
YOUNG ADULT IN THE 30'S, LEUKEMIA?
Definition
AML
Term
CALLA POSITIVE, CD 10 +, POS = CYTOPLS MARKERM, AGRANULAR
Definition
ALL
Term
MEDAISTINAL MASS, LYMPHOBLAST, LDH AND URIC ACID ELEVATED
Definition
ALL
Term
4;11 BAD NEWS, 12;22 GOOD PROGNOSIS
Definition
ALL
Term
ACute Lymphoid Leukemia (ALL) Tx?
Definition

DAUNORUBICIN, VINCRISTINe, FLUDARABINE, PREDNISONE -

 

ALLOPURINOL N' PREDNISONE FOR TUMOR LYSIS (worst complication)

 

dna chelator, microtubule inhib, purine analong, n steriod

Term
M3, AUER RODS 15/17
Definition
AML
Term
ATRA - VIT A RETIONIC ACID, GRANULAR
Definition
AML
Term
CD 34+ WITH DECREASED LAP SCORE, ANTIPLATELET ANTIBODY POS, SUDDAN POS
Definition
AML
Term
GREATEST TUMOR LYSIS SYNDROME
Definition
AML - TX WITH ALLOPURINOL (CUZ TONS OF URIC ACID BEING DUMPED INTO SERUM FORM CELL LYSIS)
Term
AML TX
Definition
DAUNORUBICIN, PREDNISONE, ARA C
Term
AGRANULAR, DIFFUSED LYMPHANOPATHY, WBC 20K, 60yo LEUKEMIIA
Definition
CLL
Term
SMUDGE CELLS, CD5+, DARK CHROMATIN NUCLEI, HYPOGAMMAGLOBULIN
Definition
CLL, SMUDGE CELL (FRAGILE WBC) - ALSO LEAD TO AUTOIMMUNE HEMOLYTIC ANEMIA
Term
CLL TX EARLY/LATE STAGE?
Definition
EARLY STAGE IS SUPPORTIVE (OBSERVE), LATE STAGE - CHOLARAMBUCIL - 'there is cll in the name of the drug lol'
Term
granular leukemia, middle aged women,
Definition
CML
Term
PHILADELPHIA CHR 9;22
Definition
CML
Term
BCR ABL - LOW LAP SCORE -
Definition
Term
LOW LAP SCORE DIFF DX?
Definition
LAP SCORE DIFF DX OF LEUKOMOID REACTION WITH LAP SCORE ELEVATED
Term
CML worst nightmare?
Definition
BLAST CRISIS - CONVERTS IN AML AND WILLDIE, INCREASE IN BLAST IN THE PERIPHERAL BLOOD
Term
CML RX?
Definition
BONE MARROW TRANSPLANT, IMANTINIB MESYLATE (GLEEVAC) - TYRONE KINASE INHIBITOR - ALPHA INTERFERON (GOOD FOR DECREASING T3/T4 AND MJ DEPRESSION) - AND HYDROYUREA
Term
DIFFERENT TYPES OF HODGKINS LYMPHOMA
Definition
NODULAAR SCLEROSIS - LYMPHOCYTE PRED - LYMPHOCYTE DEP(WORST PROG) - MIXED LYMPH/HISTRIOCYTIC (LACUNAR CELL!*)
Term
HODGKIN'S + nON HODGKIN'S LYMPHOMA TREATMENT?
Definition
MOPP / CHOP
MECHLOSETHAMINE, ONOCOUVIN (VINCRISTINE), PROCARBAZINE, PREDNISONE
-
CYTOXAN (CYCLOPHOSPHOMIDE), HYDROXYUREA, ONCOUVIN (VINCRISTINE), PROCARBAZINE
Term
RX FOR HODGKINS?
Definition
MECHLOSAETHAMINE, ONCOUVIN (VINCRISTINE), PROCARBAZINE, N' PREDNISONE
Term
RX FOR NON-HODGKINS?
Definition
CYTOXAN (CYCLOPHOSPHOMIDE),HYDROXYUREA, ONCOUVIN (VINCRISTINE), AND PROCARBAZINE
Term
LYMPHOMA TX - GENERAL RX?
Definition
ADRIAMYCIN, BLEOMYCIN, VINCRISTINE, DACARBAZINE
Term
8 DRUGS THAT CAUSE NEUTROPENIA?
Definition
'CCC P/M T D M"
COLCHICINE, CARBAMAZEPINE, CLOZAPINE, PTU/MMI, TICLOPIDINE, DAPSONE, METHOTRAXATE
Term
INCREASED LAP SCORE?, HCT>60% , SPLENOMEGALY, ELEVATED RBC, EPO DOWN
Definition
POLYCYTHEMIA RUBRA VERA
Term
ESSENTIAL THROMBOCYTHEMIA
Definition
PLATELETS OUTTA CONTROL, PLATELET >600K -ALL OTHER CELL LINES ARE ALSO INCREASED
Term
FATTY INFILTRATE IN BONE MARROW? DX? ORGANISMS?
Definition
ALL CELL LINES DEPLETED, APLASTIC ANEMIA, PARVOVIRUS B19, HEP E, AND HEP C. RX CAUSED (CHLORAMPHENICOL, AZT, VINBLASTINE, BENZENE)
Term
LOW RETICULOCYTE COUNT, BONE MARROW SCARRING?
Definition
TEAR DROP CELLS - MYELOFIBROSIS
Term
IMMUNE - INNATE
Definition
SKIN, MUCOUSMB, NON SPECIFIC, COMPLEMENT AND NEUTROPHILS (HUMORAL), AND MACROPHAGES AND NK (CELL MEDIATED CD 56, 16) --> RESPONSE TO INFLAMMATION, IMMEDIATE RESPONSE,LYSIS, ENGULFS ANTIGEN/INVADER
Term
IMMUNE - ACQUIRED
Definition
ADAPTIVE, SPECIFIC, DIVERSITY, MEMORY CELL,B CELL/PLASMA CELL AND T CELL AND MACROPHAGES --> THo into TH1 AND TH2
Term
TH1?
Definition
MACROPHAGES AND T CELLS
Term
MACROPHAGES SECRETE?
Definition
IL1 AND TNF ALPHA
Term
WHAT CELLS ARE DERIVED FROM THE BM, MATURE IN THE BM, THE CONTINUE TO THE GERMINAL CENTERS TO GET ACTIVATED?
Definition
B CELLS
Term
WHAT CELLS ARE DERIVED FROM THE BM, MATURE IN THE THYMUS, AND DIFFERENTIATE IN THE PARACORTEX?
Definition
T CELLS
Term
HOT T Bone stEAk ?
Definition
IL 1 - FEVER, IL 2 - T CELLS, IL 3 - B CELLS, IL 4 - CLASSSWITCH TO IgE, AND IL 5 - CLASS SWITCH TO IgA
Term
WHAT CD MARKER NEEDED FOR DIFFERTIATION BETWEEN B N' T CELL?
Definition
T CELL TALK TO B CELL VIA CD 40 LIGAND, B CELLS DISPLAY THE CD 19, 20
Term
CD MARKER FOR B CELL DIFFERIATIONS DURING ACUTE SWELLING?
Definition
IL 6
Term
PRIMARY RESPONSE 3-22d?
Definition
IgM
Term
PRIMARY RESPONSE AT 22d?
Definition
IgG
Term
ARRIVES IN 3D, PEAKS AT 2 WK, LASTS FOR 2 MO?
Definition
IgM
Term
ARRIVES IN 2 WK, PEAKS AT 2MO, AND LAST FOR 1YR
Definition
IgG
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